A5083928066- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ophthalmology and Eye Disorders
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Migraine and Headache Studies
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Carbon Nanotubes in Composites
- Graphene research and applications
- Hearing Loss and Rehabilitation
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Noise Effects and Management
- Autophagy in Disease and Therapy
- Nerve injury and regeneration
- Mast cells and histamine
- Ocular Surface and Contact Lens
- Ear Surgery and Otitis Media
- Endoplasmic Reticulum Stress and Disease
- Medical and Biological Sciences
- Kruppel-like factors research
- Multisensory perception and integration
Huazhong University of Science and Technology
2015-2025
Hebei Medical University
2024-2025
Union Hospital
2006-2025
Union Hospital
2013-2024
Second Hospital of Hebei Medical University
2024
Pennsylvania State University
2008-2023
Weatherford College
2023
Sun Yat-sen University
2021
State Key Laboratory of Ophthalmology
2021
Fudan University
2014-2020
Nanoparticle (NP)-bioconjugates hold great promise for more sensitive disease diagnosis and effective anticancer drug delivery compared with existing approaches. A critical aspect in both applications is cellular internalization of NPs, which influenced by NP properties cell surface mechanics. Despite considerable progress optimization the NP-bioconjugates improved targeting, role substrate stiffness on uptake has not been investigated. Using polyacrylamide (PA) hydrogels as model substrates...
The vestibular system may have a critical role in the integration of sensory information and maintenance cognitive function. A dysfunction has significant impact on quality life. Recent research provided evidence connection between functions, such as spatial memory, navigation attention. Although exact mechanisms linking to cognition remain elusive, researchers identified various pathways. Vestibular lead degeneration cortical network regions adversely affect synaptic plasticity neurogenesis...
Proliferating cancer cells preferentially use anaerobic glycolysis rather than oxidative phosphorylation for energy production. Hexokinase 2 (HK2) is highly expressed in many malignant and necessary glycolysis. The role of HK2 laryngeal squamous cell carcinoma (LSCC) unknown. In this study, the expression LSCC was investigated effect inhibiting with small hairpin RNA (shRNA) on tumor growth investigated. Using immunohistochemistry, assessed tissues. Human Hep-2 were stably transfected a...
Abstract Malignant gliomas (MGs) are one of the most common primary brain cancers in adults with a high mortality rate and relapse rate. Thus, finding better effective approaches to treat MGs has become very urgent. Here, we studied effects cryptotanshinone (CTS) on vitro vivo , explored underlying mechanisms. Effects CTS cell proliferation, cycle, migration invasion were evaluated. The activation JAK/STATs signaling was detected by western blot immunofluorescenc staining. SHP-2 inhibitor or...
Predicting emissions from internal combustion engines using traditional mathematical and physical methods presents considerable difficulties due to the complex variable operating conditions of these engines. To address issues, this study employs a novel approach by integrating Marine Predators Algorithm (MPA) with LightGBM model. The optimization algorithm ascertains model's hyperparameters, facilitating accurate emission predictions. Data collected Ricardo engine experiments serve as...
Workplace violence is one of the major public health problems in world. In China, problem hospital workplace has been improved, but it remains significant. order to prevent and punish such adverse events, China introduced a series policies measures, however, there still lack evaluative research on effectiveness these policies. This paper, PMC-Index model was used establish policy quantitative evaluation index system based high-frequency words texts China. The consistency, advantages...
Abstract In response to changes in microenvironment, macrophages polarize into functionally distinct phenotypes, playing a crucial role the pathogenesis of inflammatory bowel disease (IBD). Here, we investigated effects sorting nexin 10 (SNX10), protein involved endosomal trafficking and osteoclast maturation, on regulation macrophage polarization progression mouse colitis. Our results revealed that SNX10 deficiency increased population M2-type monocytes/macrophages protected against colonic...
Hepatic gluconeogenesis makes a significant contribution to the pathogenesis of obesity and its related insulin resistance. Cystathionine γ-lyase (CSE; also cystathionase), principal hydrogen sulfide (H2S)-synthesizing enzyme in liver, is involved glucose lipid metabolism disorders. However, roles precise mechanisms CSE/H2S resistance remain obscure. Here we show that CSE knockout exacerbated high-fat diet-induced mouse as well Further study elucidated inhibition AMPK signaling pathways by...
Vestibular rehabilitation (VR) is now a subject of active studies and has been shown to be effective for multiple vestibular disorders, peripheral or central. VR physical therapy that helps train the central nervous system compensate dysfunction. There moderate strong evidence safe management Nonetheless, on how works dysfunction remains scanty.This article addressed strategies possible mechanisms, including function might improve upon rehabilitation. In addition, it provides some examples...
We perform molecular dynamics simulations to elucidate lithiation induced fracture mechanisms of defective single-walled carbon nanotubes (SWCNTs). Our reveal that variations defect size and lithium concentration set two distinct modes the SWCNTs upon uniaxial stretch: abrupt retarded fracture. Abrupt either involves spontaneous weakening propagating crack tip or is absent participation, while features a “wait-and-go” extension process in which periodically arrests waits be weakened by...
Abstract Amino-acid metabolism plays a vital role in mammalian target of rapamycin (mTOR) signaling, which is the pivot colorectal cancer (CRC). Upregulated chaperone-mediated autophagy (CMA) activity contributes to regulation cells. Previously, we found that sorting nexin 10 (SNX10) critical regulator CMA activation. Here investigated SNX10 regulating amino-acid and mTOR signaling pathway activation, as well impact on tumor progression mouse CRC. Our results showed deficiency promoted...
Noise-induced hearing loss (NIHL) is a prevalent form of adult impairment, characterized by oxidative damage to auditory sensory hair cells. Although certain dihydropyridines, the L-type calcium channel blockers, exhibit protective properties against such damage, ability third-generation dihydropryidines like lercanidipine mitigate NIHL remains unclear.We utilized glucose oxidase (GO)-treated OC1 cell lines and cochlear explants evaluate influence on To further investigate its effectiveness,...