A5101796187- Lung Cancer Treatments and Mutations
- Amyotrophic Lateral Sclerosis Research
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Folate and B Vitamins Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurogenetic and Muscular Disorders Research
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- Trace Elements in Health
- Atherosclerosis and Cardiovascular Diseases
- Cholinesterase and Neurodegenerative Diseases
- Ferroptosis and cancer prognosis
- Cancer therapeutics and mechanisms
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- IL-33, ST2, and ILC Pathways
- Colorectal Cancer Treatments and Studies
- Fluoride Effects and Removal
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Pancreatitis Pathology and Treatment
- Machine Learning in Healthcare
Capital Medical University
2021-2025
Affiliated Hospital of Hebei University
2019-2025
Second Xiangya Hospital of Central South University
2020-2024
Central South University
2020-2024
Capital University
2024
Wannan Medical College
2023
Union Hospital
2016-2023
Huazhong University of Science and Technology
2016-2023
Zhengzhou University
2016-2022
China Medical University
2022
Ebola virus infection can cause severe hemorrhagic fever with a high mortality in humans. The outbreaks of viruses 2014 represented the most serious epidemics history and greatly threatened public health worldwide. development additional effective anti-Ebola therapeutic agents is therefore quite urgent. In this study, via throughput screening Food Drug Administration-approved drugs, we identified that teicoplanin, glycopeptide antibiotic, potently prevents entry envelope pseudotyped into...
Gastric cancer (GC) is one of the main causes death. The tumor microenvironment has a profound effect on inducing growth, metastasis, and immunosuppression. Fibroblast activation protein-α (FAP) protein that usually expressed in fibroblasts, such as cancer-associated which are major components microenvironment. However, role FAP GC progression treatment still unknown. In this study, we explored these problems based patient samples experimental models. We found high expression was an...
Cerebral cavernous malformations (CCMs) are hemorrhagic vascular disorders with varied clinical and radiological presentations, occurring sporadically due to MAP3K3 or PIK3CA mutations through inherited germline of CCM genes. This study aimed clarify the clinical, genetic, pathological features CCMs using a multicenter cohort across three Chinese centers. We analyzed 290 surgical specimens from symptomatic patients, utilizing whole-exome sequencing, droplet digital PCR, targeted panel...
Objective Epithelial ovarian cancer (EOC) is the most common and lethal type of cancer, cross-talk between tumor cell ferroptosis macrophages essential to progression. This study aims investigate roles ubiquitin-specific protease 7 (USP7) acyl-CoA synthetase long-chain family member 4 (ACSL4) in pathogenesis EOC. Material Methods The expression patterns USP7 ACSL4 EOC lines were first determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) Western blot....
Abstract Background Lupus erythematosus (LE) is a spectrum of autoimmune diseases. Due to the complexity cutaneous LE (CLE), clinical skin image‐based artificial intelligence still experiencing difficulties in distinguishing subtypes LE. Objectives We aim develop multimodal deep learning system (MMDLS) for human‐AI collaboration diagnosis subtypes. Methods This multi‐centre study based on 25 institutions across China assist subtypes, other eight similar diseases and healthy subjects. In...
Previous studies have reliably identified iron deposition in the motor cortex as potential pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we intended to investigate deposition, gray matter (GM) atrophy, and their associations with disease severity thalamus patients ALS.A total 34 ALS (age 51.31 ± 8.24 years, 23 males) nonneurological controls 50.96 9.35 19 were enrolled between 2018 2020. The Revised Functional Rating Scale (ALSFRS-R) Penn upper neuron (UMN) score measured. MRI...
Objective: To compare the clinicopathological features and chemotherapy response of ovarian clear cell carcinoma (CCC) endometrioid (EC) associated with endometriosis or not.Methods: This was a retrospective study 128 patients diagnosed CCC EC from 2002 to 2017. Clinicopathological were analyzed.Results:There 34 women endometriosis-associated cancer (EAOC) 94 non-endometriosis (non-EAOC) according Sampson's Scott's criteria. The mean diagnosis age in EAOC group 48.65 vs. 54.39 years non-EAOC...
The natural history of spinal cord cavernous malformations (SCCMs) remains relatively unclear.To investigate the for hemorrhagic risks and neurological outcomes, as well relevant predicting factors, SCCMs.All patients between 2002 2019 with diagnosis SCCMs were identified retrospectively. An observational study conservative management was performed to reveal SCCMs.We 305 in full cohort, including 126 who conservatively treated at least 6 months (median period, 24.0 months). Forty-five...
The association between visceral adiposity index (VAI) and the prevalence of non-alcoholic fatty liver disease (NAFLD) has not been fully determined. Here, we aimed to explore VAI NAFLD in general US population, further investigate whether involves population differences.Cross-sectional population-based study.The National Health Nutrition Examination Survey (2003-2018).A total 7522 participants aged 20 years or older who have complete information for assessment test were included this...
Abstract Although antiviral drugs are available for the treatment of influenza infection, it is an urgent requirement to develop new regarding emergence drug‐resistant viruses. The nucleoprotein ( NP ) conserved among all A viruses IAV s) and has no cellular equivalent. Therefore, ideal target development inhibitors. In this study, we identified a novel anti‐influenza compound, ZBMD ‐1, from library 20,000 compounds using cell‐based infection assays. We found that ‐1 inhibited replication...