A5018241330- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Cerebrovascular and Carotid Artery Diseases
- Viral gastroenteritis research and epidemiology
- Spinal Dysraphism and Malformations
- Cervical and Thoracic Myelopathy
- Viral Infections and Immunology Research
- Cerebral Venous Sinus Thrombosis
- Spinal Hematomas and Complications
- Spine and Intervertebral Disc Pathology
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Advanced MRI Techniques and Applications
- Sexual Differentiation and Disorders
- Anesthesia and Pain Management
- Pituitary Gland Disorders and Treatments
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Central Venous Catheters and Hemodialysis
- Aortic Disease and Treatment Approaches
Capital Medical University
2016-2025
Beijing Xuanwu Traditional Chinese Medicine Hospital
2020-2025
Capital University
2024-2025
People's Hospital of Xinjiang Uygur Autonomous Region
2025
Can Tho University
2024
Beijing Chest Hospital
2024
Xuan Wu Hospital of the Capital Medical University
2022-2024
Third Xiangya Hospital
2024
Central South University
2024
University of Shanghai for Science and Technology
2024
Brain and spinal arteriovenous malformations are congenital lesions causing intracranial haemorrhage or permanent disability especially in young people. We investigated whether the vast majority all brain associated with detectable tumour-related somatic mutations. In a cohort of 31 patients (21 10 malformations), tissue paired blood samples were analysed ultradeep next generation sequencing panel 422 common tumour genes to identify used droplet digital polymerase chain reaction confirm...
Abstract Cavernous malformations affecting the CNS occur in ∼0.16–0.4% of general population. The majority (85%) cavernous are a sporadic form, but genetic background remains enigmatic. Of 81 patients, 73 (90.1%) patients were detected carrying somatic missense variants two genes: MAP3K3 and PIK3CA by whole-exome sequencing. mutation spectrum correlated with lesion size (P = 0.001), anatomical distribution < MRI appearance 0.004) haemorrhage events 0.006). was significant predictor...
Cavernous malformations (CMs) invading the central nervous system occur in ~0.16-0.4% of general population, often resulting hemorrhages and focal neurological deficits. Further understanding disease mechanisms therapeutic strategies requires a deeper knowledge CMs humans. Herein, we performed single-cell RNA sequencing (scRNA-seq) analysis on unselected viable cells from twelve human CM samples three control samples. A total 112,670 high-quality were clustered into 11 major cell types,...
<h3>BACKGROUND AND PURPOSE:</h3> Spinal arteriovenous shunts below the conus constitute 3 types of lesions, which have previously been mainly described in case reports, given their rarity, and are sometimes misdiagnosed. The purpose this study was to describe features each type compare these as epidemiologic features, clinical radiologic presentations, treatment, outcomes a consecutive series 48 cases. <h3>MATERIALS METHODS:</h3> prospectively collected data bases 2 referral centers for...
Optimal surgical strategies for intramedullary spinal cord cavernous malformations (ISCCMs) are not optimized and remain problematic. In this study the authors identify rational ISCCMs predictors of outcomes after resection.
Open surgery has traditionally been preferred for the management of bifurcation middle cerebral artery (MCA) aneurysms. Flow diverting stents present a novel endovascular strategy aneurysm treatment.To add to limited literature describing outcomes and complications in use flow diverters treatment these complex aneurysms.This is multicenter retrospective review MCA aneurysms undergoing diversion. We assessed post-treatment radiological both thromboembolic hemorrhagic complications.We reviewed...
Background The short-term outcomes and prognostic factors of patients with spinal dural arteriovenous fistulas (SDAVFs) have not been defined in large cohorts. Objective To define the clinical SDAVFs. Methods A prospective cohort 112 SDAVFs were included consecutively this study. serially evaluated modified Aminoff Logue’s Scale (mALS) one day before surgery at 3 months, 6 months 12 after treatment. Univariate multivariate analyses performed to identify demographic, procedural related...
The natural history of intradural spinal cord arteriovenous shunts is unknown. We performed an observational study in a consecutive patient cohort with symptomatic who were admitted to three institutes investigate the clinical course this complex disease, which would provide valuable evidence inform decision-making. patients from initial presentation occurrence deterioration, initiation treatment, or last follow-up was analysed. Patients at least 1 month observation included study. Clinical...
The Pipeline Embolization Device (PED; Medtronic) has been used off-label for the treatment of challenging posterior circulation aneurysms. Data on this modality are primarily limited to small retrospective single-center series.To assess safety and efficacy by establishing an international, multicenter collaboration.Consecutive aneurysms treated with PED from 2012 2019 across 11 neurovascular centers were retrospectively reviewed. Baseline demographics, aneurysm characteristics,...
Background Craniocervical junction (CCJ) arteriovenous fistulas (AVFs) are rare. The current treatment strategies for AVFs with different angioarchitecture need to be clarified. present study aimed analyse the correlation between and clinical characteristics, share our experience in treating this disease identify risk factors associated subarachnoid haemorrhage (SAH) poor outcomes. Methods A total of 198 consecutive patients CCJ from neurosurgical centre were retrospectively reviewed....
OBJECTIVE Isolated spinal aneurysms (ISAs) are rare causes of subarachnoid hemorrhage (SAH), which encompass a highly heterogeneous group clinical entities with multifarious pathogeneses, characteristics, and treatment strategies. Therefore, knowledge about the ISAs remains inadequate. In this study, authors present comprehensive analysis data associated at their institutions to enhance understanding disease. METHODS Patients confirmed by angiography or surgery authors’ between 2015 2022...
The MUTYH gene encodes a DNA glycosylase that can initiate the base excision repair pathway and prevent G:C > T:A transversion by excising adenine mispaired with 8‐hydroxyguanine. Biallelic germline mutations of have been shown to predict familial sporadic multiple colorectal adenomas carcinomas, however, whether there is an association between single nucleotide polymorphisms (SNPs) cancer (CRC) risk has remained unclear. In this study we investigated four SNPs, IVS1+11C T, IVS6+35G A,...
Cerebral cavernous malformations (CCMs) are hemorrhagic vascular disorders with varied clinical and radiological presentations, occurring sporadically due to MAP3K3 or PIK3CA mutations through inherited germline of CCM genes. This study aimed clarify the clinical, genetic, pathological features CCMs using a multicenter cohort across three Chinese centers. We analyzed 290 surgical specimens from symptomatic patients, utilizing whole-exome sequencing, droplet digital PCR, targeted panel...
Background Intracranial dural arteriovenous fistulas (DAVFs) are rare lesions, making it challenging to fully understand and improve their management. Globally, only two major large-scale studies have focused on DAVFs. This report outlines the design of DREAM-INI (Dural fistula research management in China) project provides an overview 1101-patient cohort includes. Methods Patient data were sourced from database, a retrospective, single-center observational study conducted January 2001...
With advancements in endovascular techniques, an increasing number of tentorial dural arteriovenous fistulas (TDAVFs) can now be successfully treated with intervention alone. In this study, we present a summary one single-center experience the treatment TDAVFs, along subgroup analysis based on Lawton classification. We conducted retrospective review patients TDAVF at single center over 21-year period. Patients TDAVFs were included and categorized into 6 types. Patient demographics...
<title>Abstract</title> <bold>Purpose:</bold> Treating small-caliber vessel aneurysms with flow diverters presents challenges due to narrow luminal diameters and tortuous vasculature, which make navigation deployment of conventional devices using standard microcatheters more difficult. The Silk Vista Baby (SVB, Balt, Montmorency, France) diverter was developed treat intracranial located in smaller vessels or distal lesions is compatible 0.017″ microcatheters. We present the largest...
BACKGROUND AND OBJECTIVES: Comparing microsurgery and embolization for spinal cord arteriovenous malformations (SCAVMs) is challenging because of the disease's rarity highly heterogeneous angioarchitecture. The aim this study was to compare outcomes between using a grading system SCAVMs that effectively stratifies angioarchitectural complexities. METHODS: A total 714 patients were included, with 308 undergoing microsurgery. developed based on independent risk factors incomplete resection,...