A5044599007- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Spinal Dysraphism and Malformations
- Pain Mechanisms and Treatments
- Spinal Cord Injury Research
- Cerebrospinal fluid and hydrocephalus
- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Sarcoma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
- Transcranial Magnetic Stimulation Studies
- Glioma Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Nerve Injury and Rehabilitation
- Spinal Hematomas and Complications
- Nerve injury and regeneration
- Botulinum Toxin and Related Neurological Disorders
- Infectious Diseases and Tuberculosis
- Pelvic and Acetabular Injuries
- Meningioma and schwannoma management
- Management of metastatic bone disease
Capital Medical University
2016-2025
Chinese Institute for Brain Research
2020-2025
Beijing Xuanwu Traditional Chinese Medicine Hospital
2020-2024
ORCID
2024
Xuan Wu Hospital of the Capital Medical University
2016-2024
Capital University
2023
L'Alliance Boviteq
2023
Johns Hopkins University
2018-2022
Johns Hopkins Medicine
2018-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2016
Lumbar disc herniation is a syndrome triggered by degenerative changes in the intervertebral disc. Based on technique of ALIF, combining concept Anterior Cervical Discectomy and Fusion (ACDF), we summarized (ALDF) our previous clinical experience. This study to explore efficacy safety this method for treating lumbar herniation. We retrospectively analyzed medical records 44 patients with L5/S1 treated Department Neurosurgery, Xuanwu Hospital, Capital Medical University, from December 2020...
Abstract Background The spinal inflammatory signal often spreads to distant segments, accompanied by widespread pain symptom under neuropathological conditions. Multiple cytokines are released into the cerebrospinal fluid (CSF), potentially inducing activation of an cascade at remote segments through CSF flow. However, detailed alteration in neuropathic and its specific role remain obscure. Methods A chronic constriction injury infraorbital nerve (CCI-ION) model was constructed, pain-related...
Neural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies. The recently proposed hierarchical platinum-iridium (Pt-Ir) electrodes produced by femtosecond lasers have exhibited superior electrochemical performance in vitro, but their vivo is still unclear. In this study, we explored performance, biological response, tissue adhesion Pt-Ir implantation adult rat brains for 1, 8, 16 weeks. Regular smooth were used as a control....
Although cerebrospinal fluid (CSF)-based liquid biopsy was proved to be practical in molecular analysis of intracranial gliomas, primary intramedullary astrocytoma rarely reported. Given the distinct genomic profiles between glioma and astrocytoma, whether feasibility CSF-based gliomas can replicated spinal cord needs investigated. The aim this pilot study is evaluate through sequencing CSF-derived circulating tumor DNA (ctDNA).Two grade IV diffuse midline 1 II, I were included....
Abstract BACKGROUND The management of atlantoaxial dislocation (AAD) associated with basilar invagination (BI) is challenging, and traditional posterior-only approaches lack the ability to release anterior soft tissue resulting in unsatisfactory reduction. Furthermore, vertebral artery anomalies deformed anatomy increase surgical risks. OBJECTIVE To introduce a safe efficient technique reduce congenital AAD BI through single-stage approach. METHODS A total 65 patients concomitant who had...
Abstract Introduction: Paclitaxel-induced peripheral neuropathy (PIPN) is a common dose-limiting side effect of this cancer treatment drug. Spinal cord stimulation (SCS) has demonstrated efficacy for attenuating some neuropathic pain conditions. Objective: We aim to examine the inhibitory SCS on development PIPN and changes gene expression in spinal male rats after SCS. Methods: examined whether traditional (50 Hz, 6–8 h/session daily 14 consecutive days) administered during paclitaxel (1.5...
Chordoma is a rare bone tumor that frequently recurs after surgery, and the prognosis poor with current treatments. This study aimed to identify potential novel immunotherapeutic targets for chordomas by identifying target proteins in clinical samples as well microenvironmental factors enhance efficacy. Fourteen chordoma were analyzed single-cell RNA sequencing, B7-H3 IL-7 identified potentiators, respectively. B7-H3-targeted chimeric antigen receptor T (CAR-T) cells CAR-T expressing...
Revision surgery for patients with persistent, recurrent, or progressive syringomyelia following foramen magnum decompression (FMD) Chiari malformation I-syringomyelia (CM-SM) is not uncommon and presents both strategic technical challenges. We conducted a retrospective study including all who underwent revision Cerebellar Tonsillectomy (CTL) CM-SM between 2003 2023. Additionally, we performed uni- multivariate analyses to identify possible factors contributing failed CTL outcomes....
BACKGROUND AND OBJECTIVES: The exact pathways of fluid outflow within the central canal (CC) spinal cord are not completely understood. best management approach for patients with post-traumatic syringomyelia that progresses to cranial end CC, also known as syringobulbia (PT-syringobulbia), is still a topic debate. This study aims introduce new surgical indication foramen magnum and Magendie dredging (FMDD) procedure in PT-syringobulbia prospectively assess its outcomes. METHODS: included 15...
Spinal cord injury (SCI) has been a research hotspot for its poor prognosis and limited effects in current treatment methods. Consistent hostile responses damaged regions functional incapabilities can lead to major complications. Most approaches focus on either structural or reconstruction. For restoring function, facilitating innate neuroplasticity neuromodulation showed promising potentials, including rehabilitation therapy various forms of electrical stimulation, examples include epidural...
OBJECTIVE The objective of this study was to develop a vertebral artery (VA) classification system that improves risk assessment using 2D map the VA position at craniovertebral junction (CVJ), and outline surgical strategies for managing anomalous VAs during posterior atlantoaxial joint release, distraction, fusion technique in treatment basilar invagination (BI) instability (AAI). METHODS In retrospective study, 125 patients (mean age 44.1 years) with BI AAI who underwent surgery between...
Abstract Spinal cord injury (SCI) is a severe neurological disorder; however, current treatment methods often fail to restore nerve function effectively. stimulation via electrical signals promising therapeutic modality for spinal injury. Based on similar principles, this review aims explore the potential of optical and acoustic neuromodulation techniques, emphasizing their benefits in context Photoacoustic imaging, renowned its noninvasive nature, high-resolution capabilities,...