A5011986143- Herpesvirus Infections and Treatments
- RNA modifications and cancer
- Asthma and respiratory diseases
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Toxin Mechanisms and Immunotoxins
- Fungal Infections and Studies
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Respiratory viral infections research
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Biochemical Acid Research Studies
- Advanced Proteomics Techniques and Applications
State Key Laboratory of Respiratory Disease
2016-2025
Guangzhou Medical University
2016-2025
Shanxi Province Hospital of Traditional Chinese Medicine
2025
Beijing Center for Disease Prevention and Control
2024-2025
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Sichuan University
2024
Beijing Radiation Center
2024
Peking University People's Hospital
2008-2024
Peking University
2007-2024
Ebola virus infection can cause severe hemorrhagic fever with a high mortality in humans. The outbreaks of viruses 2014 represented the most serious epidemics history and greatly threatened public health worldwide. development additional effective anti-Ebola therapeutic agents is therefore quite urgent. In this study, via throughput screening Food Drug Administration-approved drugs, we identified that teicoplanin, glycopeptide antibiotic, potently prevents entry envelope pseudotyped into...
Glycoprotein D (gD) is a structural component of the herpes simplex virus (HSV) envelope which essential for entry into host cells. Chinese hamster ovary (CHO-K1) cells are one few cell types nonpermissive many HSV strains. However, when these transformed with gene herpesvirus mediator (HVEM), resulting cells, CHO-HVEM12, permissive strains, such as HSV-1(KOS). By virtue its four cysteine-rich pseudorepeats, HVEM member tumor necrosis factor receptor superfamily proteins. Recombinant forms...
Objectives: Epithelial‐mesenchymal transition (EMT) is an important process in tumor development, and several studies suggest that the Wnt/β‐catenin signal pathway may play role EMT. However, there no direct evidence showing actually determines EMT induced by exogenous signal. Our previous research has successfully proved overexpression of hypoxia‐inducible factor‐1α (HIF‐1α) could induce LNCaP cells, but not PC‐3. The present study aims to determine whether HIF‐1α for inducing prostate...
BACKGROUND. Chimeric antigen receptor (CAR) T cells have emerged as an approach to treat malignant tumors. This strategy has also been proposed for the treatment of HIV-1 infection. We developed a broadly neutralizing antibody–derived (bNAb-derived) CAR cell therapy that can exert specific cytotoxic activity against HIV-1–infected cells.
We previously reported that an ortholog of STING regulates infection by picorna-like viruses in Drosophila In mammals, is activated the cyclic dinucleotide 2'3'-cGAMP produced cGAS, which acts as a receptor for cytosolic DNA. Here, we showed injection flies with induced expression dSTING-regulated genes. Coinjection panel RNA or DNA resulted substantially reduced viral replication. This 2'3'-cGAMP-mediated protection was still observed mutations Atg7 and AGO2, genes encode key components...
Although mitochondria are known to be involved in host defense against viral infection, the physiological role of mitophagy, a crucial mechanism for maintaining mitochondrial homeostasis, antiviral immunity remains poorly defined. Here, we show that Parkin, central player has vital function regulating responses. Parkin-knockout mice exhibit improved clearance and survival after infection. However, Parkin deficiency does not affect signaling interferon production. Instead, augments innate...
Disseminated coccidioidomycosis (DCM) is caused by Coccidioides, pathogenic fungi endemic to the southwestern United States and Mexico. Illness occurs in approximately 30% of those infected, less than 1% whom develop disseminated disease. To address why some individuals allow dissemination, we enrolled patients with DCM performed whole-exome sequencing. In an exploratory set 67 DCM, 2 had haploinsufficient STAT3 mutations, defects β-glucan sensing response were seen 34 cases. Damaging CLEC7A...
Hepatocellular carcinoma (HCC) is the leading cause of cancer death. Kinesin family member 2C (KIF2C) has been shown as oncogene in a variety tumors. However, its role HCC remains unclear.In this study, expression level KIF2C was detected by immunohistochemical staining and RT-PCR, verified Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) Oncomine database. A curve established to evaluate diagnostic efficiency KIF2C. effect on investigated flow cytometry, Cell Counting Kit-8,...
This study aimed to identify the cultivable bacteria inhabiting intestinal tract of adult oriental fruit flies (Bactrocera dorsalis) from laboratory-reared, laboratory sterile sugar-reared, and field-collected populations, evaluate attractiveness metabolites produced by above their hosts.Fifteen bacterial isolates chosen three populations were determined at species level. These 15 strains cultured whole Luria-Bertani broth, filtered autoclaved supernatants B. dorsalis adults was using...
Influenza A virus poses serious health threat to humans. Neutralizing antibodies against the highly conserved M2 ion channel is thought offer broad protection influenza viruses. Here, we screened synthetic Camel single-domain antibody (VHH) libraries native protein. One of isolated VHHs, M2-7A, specifically bound M2-expressed cell membrane as well virion, inhibited replication both amantadine-sensitive and resistant viruses in vitro, protected mice from a lethal challenge. Moreover, M2-7A...
Background Tephritid fruit flies in the genus Bactrocera are of major economic significance agriculture causing considerable loss to and vegetable industry. Currently, there is no ideal control program. Molecular means an effective method for pest at present, but genomic or transcriptomic data members this remains limited. To facilitate molecular research into reproduction development mechanisms, finally on these pests, extensive transcriptome oriental fly dorsalis was produced using Roche...
Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression, including human nasopharyngeal carcinoma (NPC). The correlation between lncRNAs expression NPC development has not been well identified the recent literature. Recently, high-through put analysis reveals LOC100129148 is highly expressed NPC. However, whether aberrant of corrected with tumorigenesis or prognosis investigated. Herein, we was up-regulated tissues cell lines,...
The herpes simplex virus type 1 (HSV-1) gH-gL complex which is found in the virion envelope essential for infectivity and a major antigen host immune system. However, little known about precise role of entry, attempts to demonstrate immunologic or vaccine efficacy gH gL separately as have not succeeded. We constructed recombinant mammalian cell line (HL-7) secretes soluble complex, consisting truncated at amino acid 792 (gHt) full-length gL. Purified gHt-gL reacted with gH- gL-specific...