A5101575037- Service-Oriented Architecture and Web Services
- CAR-T cell therapy research
- Advanced Causal Inference Techniques
- Advanced Computational Techniques and Applications
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Photodynamic Therapy Research Studies
- Virus-based gene therapy research
- Antimicrobial agents and applications
- Nuclear Physics and Applications
- Physics of Superconductivity and Magnetism
- Acute Ischemic Stroke Management
- Quantum and electron transport phenomena
- Statistical Methods in Clinical Trials
- Medical Research and Treatments
- Advanced Glycation End Products research
- AI in cancer detection
- E-commerce and Technology Innovations
- Histone Deacetylase Inhibitors Research
- Neurological Disease Mechanisms and Treatments
- Magnetism in coordination complexes
- Network Security and Intrusion Detection
- Diabetes Treatment and Management
- Statistical Methods and Inference
- Environmental Chemistry and Analysis
Fuzhou University
2022-2025
Zhuhai Institute of Advanced Technology
2024
Soochow University
2020-2024
Shantou University
2024
Shantou University Medical College
2024
Shanghai University of Traditional Chinese Medicine
2010-2024
First Affiliated Hospital of Soochow University
2020-2024
National Clinical Research Center for Digestive Diseases
2024
University of Chinese Academy of Sciences
2019-2023
Shanghai Institute of Microsystem and Information Technology
2020-2023
Objectives To assess the efficacy of corticosteroid treatment patients with coronavirus disease 2019 (COVID-19). Design, setting Observational study in two COVID-19-designated hospitals Wuhu, Anhui province, China, 24 January – February 2020. Participants Thirty-one infected severe acute respiratory 2 (SARS-CoV-2) treated at designated hospitals. Main outcome measures Virus clearance time, length hospital stay, and duration symptoms, by type (including or not including therapy). Results...
Randomized controlled trials play an important role in how Internet companies predict the impact of policy decisions and product changes. In these “digital experiments,” different units (people, devices, products) respond differently to treatment. This article presents a fast scalable Bayesian nonparametric analysis such heterogenous treatment effects their measurement relation observable covariates. New results algorithms are provided for quantifying uncertainty associated with effect via...
Background Golgi protein-73 (GP73) is a newly identified candidate serum marker for liver diseases. The utility of this biomarker remains limited, largely due to the lack quantitative information. aims study were quantify GP73 (sGP73) in healthy individuals and patients with diseases, validate sGP73 as early diagnosis disease. Methods Recombinant was used generate monoclonal (mAb) polyclonal antibodies (pAb). Using these enzyme-linked immunosorbent assay, measured from 263 various forms...
We investigated the epidemiological and clinical data of all hand, foot, mouth disease (HFMD) cases in a sentinel hospital Shenzhen, China from 2009 to 2011.HFMD diagnosed our institution were assessed 2011. Both features analyzed retrospectively. All fatal reported.A total 12132 patients with HFMD, which 2944 (24.3%) hospitalized. Of hospitalized patients, highest proportion admitted May July (989/2944, 33.6%). In severe HFMD enterovirus 71 (EV71). 2010 2011, some Coxsackievirus A16 (CA16)....
We conducted a single-arm, open-label, single-center phase 1 study to assess the safety and efficacy of multicycle-sequential anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in combination with autologous CD19+ feeding T cells (FTCs) tyrosine kinase inhibitor (TKI) as consolidation patients under age 65 years de novo Ph-positive B-cell acute lymphoblastic leukemia. Participants were given induction chemotherapy well systemic TKI. Afterward, they received single cycle CD19 CAR...
Few studies have described chimeric antigen receptor–modified T cell (CAR-T) therapy for central nervous system (CNS) B-cell acute lymphocytic leukemia (B-ALL) patients due to life-threatening CAR-T-related encephalopathy (CRES) safety issues. In this study, CAR-Ts targeting CD19 with short hairpin RNA (shRNA)-IL-6 gene silencing technology (ssCART-19s) were prepared. We conducted a phase 1 clinical trial (ClinicalTrials.gov number, NCT03064269). Three relapsed CNS B-ALL enrolled,...
Air pollution caused by bacteria and viruses has posed a serious threat to public health. Commercial air purifiers based on dense fibrous filters can remove particulate matter, including airborne pathogens, but do not kill them efficiently. Here, we developed double-grafted antibacterial fiber material for the high-efficiency capture inactivation of microorganisms. Tetracarboxyl phthalocyanine zinc, photosensitizer, was first grafted onto polyester (PET) fiber, followed coating with chitosan...
Abstract Background Increasing evidence suggests that long noncoding RNAs (lncRNAs) play important regulatory roles in biological processes and are dysregulated numerous tumors. The lncRNA GRASLND functions as an oncogene many cancers, but its role skin cutaneous melanoma (SKCM) requires further investigation. Methods SiRNA transfection, wound − healing transwell assays were performed to evaluate the effect of on cellular function. Results present study demonstrated expression is increased...
Recent studies have suggested that G-protein-coupled receptor kinase 5 (GRK5) deficiency plays a significant role in the pathogenesis of early Alzheimer's disease. Mild soluble β-amyloid accumulation can result reduced membrane (functional) and elevated cytosolic levels GRK5. Dysfunction GRK5 impairs desensitization presynaptic muscarinic 2 (M2) autoreceptors, which results M2 hyperactivity inhibits acetylcholine (ACh) release. GRK dysfunction also promotes deleterious cycle further...
CD19 chimeric antigen receptor-T (CAR-T) cell therapy has achieved remarkable results in patients with relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-ALL). However, the cytokine release syndrome (CRS) was presented most as common toxicity and severe CRS (sCRS) characterized by sharp increase interleukin-6 (IL-6) could be life-threatening. We conducted a phase II clinical trial of ssCAR-T-19 cells, anti-CD19 CAR-T cells shRNA targeting IL-6, 61 r/r B-ALL. This registered at...
Echinomycin is a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity, which plays crucial role in ovarian ovulation mammalians. The present study was designed to test the hypothesis that factor (HIF)-1α-mediated endothelin (ET)-2 expressions contributed response human chorionic gonadotropin (hCG) during gonadotropin-induced superuvulation. By real-time RT-PCR analysis, ET-2 mRNA level found significantly decrease ovaries after echinomycin treatment, while HIF-1α and...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially emerging variants, poses an increased threat to global public health. The significant reduction in neutralization activity against the variants such as B.1.351 serum of convalescent patients and vaccinated people calls for design new potent vaccines targeting variant. However, since most approved clinical trials are based on sequence original SARS-CoV-2 strain, immunogenicity protective efficacy variant remain largely...
We developed a continuous learning system (CLS) based on deep and optimization ensemble approach, conducted retrospective data simulated prospective study using ultrasound images of breast masses for precise diagnoses. extracted 629 2235 from 561 cases in the institution to train model six stages diagnose benign malignant tumors, pathological types, diseases. randomly selected 180 out 3098 two external institutions. The CLS was tested with seven independent datasets compared 21 physicians,...