A5059554869- DNA Repair Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Ubiquitin and proteasome pathways
- Systemic Lupus Erythematosus Research
- Mitochondrial Function and Pathology
- Microtubule and mitosis dynamics
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Autoimmune and Inflammatory Disorders Research
- Autophagy in Disease and Therapy
- T-cell and B-cell Immunology
- Nanowire Synthesis and Applications
- Evacuation and Crowd Dynamics
- Amyotrophic Lateral Sclerosis Research
- Retinal Diseases and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Cancer Research and Treatments
- Inflammasome and immune disorders
- Restraint-Related Deaths
- Corneal surgery and disorders
- Histone Deacetylase Inhibitors Research
- Otitis Media and Relapsing Polychondritis
- Glaucoma and retinal disorders
- Angiogenesis and VEGF in Cancer
- Cytomegalovirus and herpesvirus research
First Affiliated Hospital of Soochow University
2012-2025
Soochow University
2016-2025
Shenzhen University
2022-2024
Shenzhen University Health Science Center
2018-2022
Institute of Zoology
2017-2019
University of Chinese Academy of Sciences
2017-2019
Chinese Academy of Sciences
2019
Guangdong Urban & Rural Planning and Design Institute
2015
Sun Yat-sen University
2006-2008
Zhongshan Ophthalmic Center, Sun Yat-sen University
2006-2007
Behçet disease (BD) is a systemic inflammatory presumably caused by an autoimmune response. The interleukin (IL)-23/IL-17 pathway has been demonstrated to be involved in the development and maintenance of certain diseases. This study was designed investigate role IL-23 IL-17 BD.IL-23p19 mRNA peripheral blood mononuclear cells (PBMCs) examined using RT-PCR. levels IL-23, IL-17, IFN-gamma sera or PBMCs were detected ELISA. Flow cytometry used evaluate frequencies IL-17-producing...
Abstract Expression of the E3 ligase TRIM21 is increased in a broad spectrum cancers; however, functionally relevant molecular pathway targeted by overexpression remains largely unknown. Here, we show that directly interacts with and ubiquitinates CLASPIN, mediator for ATR-dependent CHK1 activation. TRIM21-mediated K63-linked ubiquitination CLASPIN counteracts K6-linked which essential its interaction TIPIN subsequent chromatin loading. We further TRIM21, but not catalytically inactive...
To evaluate and compare the diagnostic accuradcy of three Fuchs' Uveitis Syndrome (FUS) criteria-La Hey Diagnostic Criteria (LHDC), Standardization Nomenclature (SUN) Criteria, Yang's Revised (RDC)-in absence a universally accepted gold standard. A multicenter, case-control study was conducted with 673 patients (331 FUS 342 non-FUS) from tertiary eye centers in China. Sensitivity, specificity, area under curve (AUC) values were calculated compared across criteria. RDC demonstrated highest...
The Chk1 protein is essential for genome integrity maintenance and cell survival in eukaryotic cells. After prolonged replication stress, can be targeted proteasomal degradation to terminate checkpoint signaling after DNA repair finishes. To ensure proper activation of damage signaling, a steady-state level needs retained under physiological conditions. Here, we report dynamic pathway that tightly regulates stability. Under unperturbed conditions upon damage, ataxin-3 (ATX3) interacts with...
DNA damage response (DDR) is essential for genome stability and human health. Recently, several RNA binding proteins (RBPs), including fused-in-sarcoma (FUS), have been found unexpectedly to modulate this process. The role of FUS in DDR closely linked the pathogenesis amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that affects nerve cells brain spinal cord. Given RBM45 also an ALS-associated RBP, we wondered whether plays any function during Here, report can be...
Translesion DNA synthesis (TLS) is one mode of damage tolerance that uses specialized polymerases to replicate damaged DNA. polymerase η (Polη) well known facilitate TLS across ultraviolet (UV) irradiation and mutations in POLH are implicated skin carcinogenesis. However, the basis for recruitment Polη stalled replication forks not completely understood. In this study, we used an affinity purification approach isolate a Polη-containing complex have identified SART3, pre-mRNA splicing factor,...
Few studies have described chimeric antigen receptor–modified T cell (CAR-T) therapy for central nervous system (CNS) B-cell acute lymphocytic leukemia (B-ALL) patients due to life-threatening CAR-T-related encephalopathy (CRES) safety issues. In this study, CAR-Ts targeting CD19 with short hairpin RNA (shRNA)-IL-6 gene silencing technology (ssCART-19s) were prepared. We conducted a phase 1 clinical trial (ClinicalTrials.gov number, NCT03064269). Three relapsed CNS B-ALL enrolled,...
Abstract DNA damage response (DDR) is essential for maintaining genome stability and protecting cells from tumorigenesis. Ubiquitin ubiquitin-like modifications play an important role in DDR, signaling to mediating repair. In this report, we found that the E3 ligase ring finger protein 126 (RNF126) was recruited UV laser micro-irradiation-induced stripes a RNF8-dependent manner. RNF126 directly interacted with ubiquitinated another ligase, RNF168. Overexpression of wild type RNF126, but not...
Purpose: To characterize the quality of life and mental health status patients with uveitis investigate predictors psychological problems.Methods: A total 245 105 controls were enrolled in this cross-sectional study. Quality life, status, socio-demographic clinical data obtained from questionnaires medical records. Multivariate regression analyses Receiver Operating Characteristic (ROC) applied to obtain model predicting problems patients.Results: Of patients, 16.7% 26.5% (P< .0001) screened...
// Xuefei Zhu 1, * , Xiaolu Ma 2, Yingfeng Tu Min Huang 2 Hongmei Liu 1 Fengli Wang Juanjuan Gong Jiuqiang Xiaoling Li Qian Chen Hongyan Shen Shu Yun Yang Caixia Guo Tie-Shan Tang State Key Laboratory of Membrane Biology, Institute Zoology, University Chinese Academy Sciences, Beijing 100101, China CAS Genomics and Precision Medicine, Genomics, These authors contributed equally to this work Correspondence to: Guo, email: guocx@big.ac.cn Tang, tangtsh@ioz.ac.cn Keywords: Parkin, translesion...
Wet age-related macular degeneration (AMD), which can cause progressive blindness, is characterised by choroid neovascularization (CNV) in the area. Although close attention has been paid to AMD, and anti-vascular endothelial growth factor (VEGF) drugs are available, its complex pathogenesis still elusive. Tie2-expressing macrophages (TEMs) have found promote angiogenesis remodel tissues tumours. This study aimed elucidate role of macrophage Tie2 signalling laser-induced CNV (LCNV). We...
Purpose: To investigate the roles of CFI, genotype-phenotype associations were identified in AAU.Methods: A case–control study was conducted a total 575 subjects consisting 279 AAU patients and 296 healthy controls. Genotypic analyses performed using Sequenom MassARRAY technology. Analyses stratified to series clinical ophthalmic confounding factors.Results: lower frequency CFI-rs13104777 C allele found cohort compared with controls, and, thus, significantly associated pathogenesis (p =...
Purpose: To assess the expression of T-cell immunoglobulin- and mucin-domain-containing molecule 3 (Tim-3) in spleens BALB/c mice undergoing anterior chamber-associated immune deviation (ACAID). Methods: ACAID was generated after intracameral (i.c.) injection ovalbumin (OVA) into evaluated by assessing delayed-type hypersensitivity (DTH) response following a subsequent subcutaneous (s.c.) OVA emulsified complete Freund's adjuvant (CFA) on Days 0, 3, 7, 14, 21 28. Tim-3 mRNA levels were...
In order to obtain the study area of residential area, method visual interpretation combined with actual survey were adopted get elusion and dispersion zone road network spatial data attribute by using remote sensing image part in Jinan. First all, ARCGIS10.0, space buffer analysis was done based on risk place, then overlay results zone. Thus we can effective eliminating danger point affected. Secondly, entrances, service divided. realize recently evacuated, methods Euclidean allocation used...