A5091139720- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Treatment of Major Depression
- Traumatic Brain Injury Research
- Acupuncture Treatment Research Studies
- Advanced biosensing and bioanalysis techniques
- Healthcare and Venom Research
- Vasculitis and related conditions
- Nanocluster Synthesis and Applications
- Intraocular Surgery and Lenses
- Galectins and Cancer Biology
- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Spondyloarthritis Studies and Treatments
- Pain Mechanisms and Treatments
- Respiratory and Cough-Related Research
- Gastroesophageal reflux and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Infectious Encephalopathies and Encephalitis
- Carbon and Quantum Dots Applications
- Natural Compounds in Disease Treatment
Affiliated Eye Hospital of Wenzhou Medical College
2016-2024
Wenzhou Medical University
2012-2024
New York University
2024
Nanjing University of Chinese Medicine
2022
National Clinical Research Center for Digestive Diseases
2022
Fujian Medical University
2008-2021
Union Hospital
2021
University of Florida
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2012
Single and repeated sports-related mild traumatic brain injury (mTBI), also referred to as concussion, can result in chronic post-concussive syndrome (PCS), neuropsychological cognitive deficits, or encephalopathy (CTE). However PCS is often difficult diagnose using routine clinical, neuroimaging laboratory evaluations, while CTE currently only be definitively diagnosed postmortem. We sought develop an animal model simulate human repetitive concussive head for systematic study. In this...
Resveratrol (RSV) is a potential alternative therapy for non-alcoholic fatty liver disease (NAFLD) that has been evaluated in many clinical trials, but the mechanisms of RSV action have not fully elucidated. Recent studies suggested gut microbiota an important target; therefore, we speculated might mediate beneficial effects NAFLD. To verify this hypothesis, established high-fat diet (HFD)-induced NAFLD mouse model, which was subjected to gavage evaluate therapeutic effects. We observed...
To quantify the inner retinal vascular changes that occur in superficial and deep layers patients with Behçet's disease (BD) remission using optical coherence tomography angiography (OCTA) to evaluate associations outer structure.Nineteen eyes from 19 BD were enrolled, including 10 less than five ocular attacks (n < 5) nine or more ≥ 5). The foveal avascular zone (FAZ) global regional vessel density (VD) both compared between normal eyes. Their structure, integrity of ellipsoid (EZ),...
Cytochrome P450 proteins (CYP 450) is the most important enzyme system of drug phase I metabolism in liver. In previous reports, reduced efficiency or increased risk adverse events can be affected by primary sequence mutation CYP450. To investigate effect gene polymorphism on ketamine vitro, including new alleles: 2C9*58, *59 and *60. Incubation which was contained insect microsome, b5, NADPH 1M PBS incubated 10 μM–1000 μM 37 °C for 40 min concentration norketamine analyzed ultra-performance...
Abstract Background Acute retinal necrosis (ARN) is a relatively rare but highly damaging and potentially sight-threatening type of uveitis caused by infection with the human herpesvirus. Without timely diagnosis appropriate treatment, ARN can lead to severe vision loss. We aimed develop deep learning framework distinguish from other types intermediate, posterior, panuveitis using ultra-widefield color fundus photography (UWFCFP). Methods conducted two-center retrospective discovery...
Purpose: To characterize the quality of life and mental health status patients with uveitis investigate predictors psychological problems.Methods: A total 245 105 controls were enrolled in this cross-sectional study. Quality life, status, socio-demographic clinical data obtained from questionnaires medical records. Multivariate regression analyses Receiver Operating Characteristic (ROC) applied to obtain model predicting problems patients.Results: Of patients, 16.7% 26.5% (P< .0001) screened...
The purpose of this paper is to study pharmacokinetics cortisone (E) and its metabolite cortisol (F) in rats after administration glycyrrhetinic acid (GA) cortisone. Healthy male SD were randomized be given 20 mg/kg E or combined with 10 GA. Blood samples collected at 5, 10, 20, 40, 60, 90, 120, 150, 180, 240 min administration. serum concentrations F determined by HLPC pharmacokinetic parameters calculated using DASver2.0 software. of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Background We aimed to investigate the causal association between TIM-3 , an immune checkpoint inhibitor, and anterior uveitis (AU), as well associated systemic diseases. Materials methods performed two-sample Mendelian randomization (MR) analyses estimate effects of on AU three diseases, namely ankylosing spondylitis (AS), Crohn's disease (CD), ulcerative colitis (UC). Single-nucleotide polymorphisms (SNPs) with AU, AS, CD, UC were selected outcomes: GWAS 2,752 patients acute accompanied AS...
Complement factor H (CFH) related proteins (CFHRs) play important roles in complement activation pathways, whereas previous studies have only shown that CFH can affect the development of uveitis. In present study, we investigated potential associations between one single-nucleotide polymorphisms CFHR2 gene with acute anterior uveitis (AAU).A total 571 subjects, 283 patients diagnosed AAU and 288 healthy adult controls, were recruited for this case-control study. CFHR2-rs2986127 was detected...
Abstract Behçet’s disease (BD) is a multi-systemic inflammatory disease. Previous reports indicated that MICA *009 confers susceptibility to BD. *049 differs from *009:01, major subtype, only at codon 335 in exon 6. However, the potential association of with BD has not been addressed. In this study, we differentiated among *049, and HLA-B *51 A Han Chinese cohort consisting 41 patients 197 ethnically matched controls were examined sequencing T-ARMS-PCR for genotyping , ARMS-PCR *51. The...