A5088750542- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Magnesium Alloys: Properties and Applications
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Hormonal Regulation and Hypertension
- Anesthesia and Sedative Agents
- Antifungal resistance and susceptibility
- Curcumin's Biomedical Applications
- Hydrogen Storage and Materials
- Advanced ceramic materials synthesis
- Eicosanoids and Hypertension Pharmacology
- Heart rate and cardiovascular health
- Plant-based Medicinal Research
- Mechanical Failure Analysis and Simulation
- Pharmacological Effects of Natural Compounds
- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Metal Alloys Wear and Properties
- Helminth infection and control
- Heart Rate Variability and Autonomic Control
- Metabolomics and Mass Spectrometry Studies
- Inflammatory mediators and NSAID effects
- Drug Transport and Resistance Mechanisms
- Acute Lymphoblastic Leukemia research
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2015-2024
Wenzhou Medical University
2015-2024
Affiliated Hospital of Qingdao University
2009-2021
Qingdao University
2009-2021
Qilu Hospital of Shandong University
2021
Dalian University of Technology
2009-2019
Marine Design & Research Institute of China
2016
Wenzhou University
2015
Dalian Medical University
2014
First Affiliated Hospital of Dalian Medical University
2014
Cytochrome P450 2C9 (CYP2C9), one of the most important phase I drug metabolizing enzymes, could catalyze reactions that convert diclofenanc into diclofenac 4′-hydroxylation. Evaluation inhibitory effects compounds on CYP2C9 is clinically because inhibition result in serious drug–drug interactions. The objective this work was to investigate curcumin human and cytochrome 2C11 (CYP2C11) rat liver microsomes. results showed inhibited activity (10 µmol L–1 diclofenac) with half-maximal or a...
The present study aimed to investigate the effect of anlotinib (AL3818) on pharmacokinetics cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C6, CYP2D1, CYP2D2, and CYP3A1/2) by using five cocktail probe drugs in vivo. After pretreatment for 7 days with (treatment group) or saline (control oral administration, phenacetin, tolbutamide, omeprazole, metoprolol, midazolam were administered rats administration. Blood samples obtained at a series time-points concentrations plasma determined UHPLC-MS/MS...
Galangin (GAL), the major bioactive flavonol extracted from Alpinia officinarum Hance (Zingiberaceae), has attracted much attention due to its multiple biological activities. To develop a fast, reliable, and sensitive ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method for quantification of GAL in rat plasma mouse tissues. UHPLC–MS/MS using electrospray ionization operating negative-ion mode was used determinate 18 rats receiving three doses (2 9 mg/kg...
The objective of this work was to investigate the effect orally administered genistein on pharmacokinetics imatinib and N-desmethyl in rats. Twenty-five healthy male SD (Sprague-Dawley) rats were randomly divided into five groups: A group (control group), B (multiple dose 100 mg/kg for consecutive 15 days), C 50 D (a single genistein), E genistein). is 30 min after administration (100 or mg/kg). pharmacokinetic parameters calculated by DAS 3.0 software. multiple significantly (<mml:math...
Abstract A sensitive and rapid ultra performance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) method was developed to determine voriconazole in human plasma. Sample preparation accomplished through a simple one‐step protein precipitation with methanol. Chromatographic separation carried out on an Acquity UPLC BEH C 18 column using isocratic mobile phase system composed of acetonitrile water containing 1% formic acid (45:55, v/v) at flow rate 0.50 mL/min. Mass spectrometric...
We investigated the effect of azole antifungal drugs (ketoconazole, voriconazole, and itraconazole) on pharmacokinetics apatinib in rats. The rats ketoconazole, itraconazole groups received single-dose 30 mg/kg after oral administration itraconazole, respectively. Co-administration ketoconazole or voriconazole significantly increased Cmax AUC(0–t) decreased clearance. did not affect parameters apatinib. It could be concluded that both increase exposure apatinib, rat. Apatinib can...
Corydalis decumbens, a Traditional Chinese Medicine, has been widely used for the alternative and/or complementary therapy of hypertension, arrhythmias rheumatoid arthritis, sciatica, stroke, hemiplegia, paraplegia, and vascular embolism. The aim this study was to determinate potential effects decumbens on five cytochrome P450 (CYP) enzyme activities (CYP1A2, CYP3A4, CYP2C9, CYP2C19, CYP2D6) by cocktail approach. To evaluate whether concurrent use interferes with effect several prescription...
Introduction: Engeletin is the main active component in engelhardia leaf that promotes circulation and removes stasis, has hypoglycemic, hypolipidemic, anti-inflammatory actions. The aim of this study was to develop an ultra-performance liquid chromatography- tandem mass spectrometry method detect engeletin plasma tissues investigate its absorption, distribution, mechanism mice, which could provide very useful information for pharmacological effect vivo. Materials Methods: Twenty-five mice...
A sensitive and rapid UPLC-MS/MS method was developed to determine ivabradine, metoprolol their corresponding metabolites in rat plasma simultaneously.
The purpose of this paper is to study pharmacokinetics cortisone (E) and its metabolite cortisol (F) in rats after administration glycyrrhetinic acid (GA) cortisone. Healthy male SD were randomized be given 20 mg/kg E or combined with 10 GA. Blood samples collected at 5, 10, 20, 40, 60, 90, 120, 150, 180, 240 min administration. serum concentrations F determined by HLPC pharmacokinetic parameters calculated using DASver2.0 software. of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
CYP2C9 is one of the most important phase I drug-metabolizing enzymes in liver. The objective this work was to investigate effects apigenin on metabolism losartan and human rat CYP2C11 activity vitro.Different concentrations were added a 100 mmol/l Tris-HCl reaction mixture containing 2 pmol/ml recombinant CYP2C9.1, 0.25 mg/ml liver microsomes or 0.5 determine half maximal inhibition half-maximal inhibitory concentration (IC50) losartan. In addition, diclofenac used as substrate performed...
Anlotinib is a novel inhibitor of receptor kinase tyrosine with multitargets and has broad spectrum inhibitory action on tumor angiogenesis growth. A simple rapid UHPLC-MS/MS bioanalytical method was validated for the determination anlotinib in rat plasma, using imatinib as an internal standard. An Acquity BEH C18 column used to separate analytes. The eluents consisted formic acid/water (0.1 : 100, v/v) acetonitrile mobile phase. triple quadrupole mass spectrometer operated quantification...