A5078253725- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Phytochemistry and Biological Activities
- Berberine and alkaloids research
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Paraquat toxicity studies and treatments
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Chromatography in Natural Products
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Neuroinflammation and Neurodegeneration Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Drug Transport and Resistance Mechanisms
- Chronic Myeloid Leukemia Treatments
- Ginseng Biological Effects and Applications
- Synthesis and bioactivity of alkaloids
- Alcohol Consumption and Health Effects
- Tryptophan and brain disorders
- Histone Deacetylase Inhibitors Research
- Alkaloids: synthesis and pharmacology
- Antibiotics Pharmacokinetics and Efficacy
- Neuroscience and Neuropharmacology Research
Wenzhou Medical University
2016-2025
China-Japan Friendship Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
China Academy of Information and Communications Technology
2025
First Affiliated Hospital of Wenzhou Medical University
2017-2023
Institute of Forensic Science
2020
Huazhong Agricultural University
2020
University of California, San Francisco
2012-2014
National Taiwan University
1992-1998
Abstract In this paper, an ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for quantifying the levels of crassicauline A, fuziline, karacoline, and songorine in rat plasma. After processing plasma, proteins plasma were separated by extracting analytes with acetonitrile–methanol (9:1, v/v). The chromatographic column used UPLC HSS T3 column, mobile phase (methanol–water 0.1% formic acid) under a gradient elution profile to separate four...
There is a lack of early specific diagnosis and effective evaluation sepsis, the clinical treatment not timely. As result, mortality high, which seriously threatens health people. Data were collected from human blood samples hospital by gas chromatography mass spectrometry. Thirty-five healthy controls 42 sepsis patients enrolled. Machine-learning techniques used to diagnose sepsis. Using metabolic data patients, proposed method has got 81.6% recognition rate, 89.57% sensitivity, 65.77%...
One-third of type 2 diabetes patients do not respond to metformin. Genetic variants in metformin transporters have been extensively studied as a likely contributor this high failure rate. Here, we investigate, for the first time, effect genetic transcription factors on pharmacokinetics (PK) and response. Overall, 546 healthy volunteers contributed their genome-wide, pharmacokinetic (235 subjects), HbA1c data (440 patients) analysis. Five specificity protein 1 (SP1), factor that modulates...
Ziyuglycoside I and ziyuglycoside II are important active components of Sanguisorba officinalis L., which have excellent pharmacological effects, such as antioxidant anticancer effects. However, the bioavailability has not been reported. This work aims to establish a UPLC-MS/MS method study pharmacokinetics in rats under different administration routes (intragastric intravenous administration) calculate bioavailability. The concentration rat plasma range 2–2000 ng/mL showed good linear...
Remote sensing data is often distributed across multiple institutions, and due to privacy concerns data-sharing restrictions, leveraging large-scale datasets in a centralized training framework challenging. Federated learning offers promising solution by enabling collaborative model sources without requiring centralization. However, current Vision-Language Models (VLMs), which typically contain billions of parameters, pose significant communication challenges for traditional federated...
As an alternative compound of bisphenol A (BPA), B (BPB) was widely used in plastic materials. The potential actions BPB on the function Leydig cells through regulation H3K27me3 and H3K9me3 remains unclear. Our goal to assess how influences cell via histone modifications mediated by H3K9me3. Male 56-day-old Sprague-Dawley rats were given with 0, 50, 100, 200 mg/kg/day oral administration for 14 days study impact rats. findings indicated that significantly reduced serum testosterone levels at...
Fibroblast growth factor 21 (FGF21), a metabolic hormone with pleiotropic effects, is beneficial for various cardiac disorders. However, FGF21's role in heart failure preserved ejection fraction (HFpEF) remains unclear. Here, we show that elevated circulating FGF21 levels are negatively associated diastolic function patients HFpEF. Global or adipose deficiency exacerbates dysfunction and damage high-fat diet (HFD) plus N[w]-nitro-L-arginine methyl ester (L-NAME)-induced HFpEF mice, whereas...
ABSTRACT Pectolinarin is a flavonoid compound known for its wound‐healing properties, including anti‐inflammatory and antibacterial effects. In this study, we employed UPLC‐MS/MS to quantify pectolinarin in rat plasma investigate pharmacokinetics. Plasma samples were processed using an acetonitrile precipitation method. Chromatographic separation was performed on UPLC BEH column with gradient mobile phase of acetonitrile‐water (containing 0.1% formic acid). Detection carried out electrospray...
Dendrobine, considered as the major active alkaloid compound, has been used for quality control and discrimination of Dendrobium which is documented in Chinese Pharmacopoeia. In this work, a sensitive simple ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method determination dendrobine rat plasma developed. After addition caulophyline an internal standard (IS), protein precipitation by acetonitrile-methanol (9:1, v/v) was to prepare samples. Chromatographic...
In this paper, we present a novel predictive model based on the kernel extreme learning machine (KELM) to predict somatization disorder. Since classification performance of KELM is largely affected by its two parameters, it necessary set optimal parameters for ensure high prediction accuracy. order improve accuracy model, new optimization strategy used optimize KELM. The adopted grey wolf algorithm generate high-quality initial populations moth-flame algorithm, called GWOMFO. effectiveness...
In this study, we developed a brain metabolomic method, based on gas chromatography-mass spectrometry (GC/MS), to evaluate the effect of ketamine rats. Pattern recognition analysis, including both principal component analysis and partial least squares-discriminate revealed that induced metabolic perturbations. Compared with control group, levels glycerol, uridine, cholesterol in rat group (50 mg/kg, 14 days) decreased, while urea increased. Our results indicate methods GC/MS may be useful...