A5053811336- Lymphatic System and Diseases
- Angiogenesis and VEGF in Cancer
- Chronic Kidney Disease and Diabetes
- Fibroblast Growth Factor Research
- Cardiac Fibrosis and Remodeling
- Occupational and environmental lung diseases
- Rock Mechanics and Modeling
- TGF-β signaling in diseases
- Electrolyte and hormonal disorders
- Liver Disease and Transplantation
- Hydrocarbon exploration and reservoir analysis
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Gut microbiota and health
- Kruppel-like factors research
- Mitochondrial Function and Pathology
- Cardiovascular Health and Disease Prevention
- Acute Kidney Injury Research
- Neuroscience of respiration and sleep
- Endoplasmic Reticulum Stress and Disease
- Drilling and Well Engineering
- Nutritional Studies and Diet
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Liver Disease Diagnosis and Treatment
Songshan Lake Materials Laboratory
2024-2025
Guangdong Medical College
2024-2025
Wenzhou Medical University
2022-2025
First Affiliated Hospital of Wenzhou Medical University
2022-2024
Ruian People's Hospital
2023
Myocardial infarction (MI) is an ischaemic cardiovascular disease associated with increased morbidity and mortality. Previous studies have suggested that serine carboxypeptidase 1 (Scpep1) involved in vascular diseases; however, its role cardiac diseases remains unclear. This study aims to explore the of Scpep1 regulating homeostasis during MI. The impact deficiency or cardiac-specific knock-down overexpression on heart function was evaluated mice Its downstream functional mediators were...
Fibroblast growth factor 21 (FGF21), a metabolic hormone with pleiotropic effects, is beneficial for various cardiac disorders. However, FGF21's role in heart failure preserved ejection fraction (HFpEF) remains unclear. Here, we show that elevated circulating FGF21 levels are negatively associated diastolic function patients HFpEF. Global or adipose deficiency exacerbates dysfunction and damage high-fat diet (HFD) plus N[w]-nitro-L-arginine methyl ester (L-NAME)-induced HFpEF mice, whereas...
BACKGROUND: BMP9 (bone morphogenetic protein 9) is a member of the TGF-β (transforming growth factor β) family cytokines with pleiotropic effects on glucose metabolism, fibrosis, and lymphatic development. However, role in myocardial infarction (MI) remains elusive. METHODS: The expressional profiles cardiac tissues plasma samples subjects MI were determined by immunoassay or immunoblot. was evaluating impact deficiency replenishment adeno-associated virus–mediated expression recombinant...
Abstract Objective Thrombospondin-2 (TSP-2) is a multifunctional matricellular glycoprotein correlated with glucose homeostasis, insulin sensitivity, and estimated glomerular filtration rate. Investigation of the association TSP-2 type 2 diabetes mellitus (T2DM) potential diagnostic value serum for detecting early diabetic kidney disease (DKD) needed. Research design methods An enzyme-linked immunosorbent assay was used detection levels in 494 Chinese T2DM subjects. The protein expression...
Diabetic nephropathy (DN), one of the major complications diabetes mellitus, is cause end-stage renal failure that finally increases risk cardiovascular disease and mortality. The aim this study to explore relationship between serum lipocalin-2 (LCN-2) levels DN carotid atherosclerotic plaque (CAP) in patients with type 2 mellitus (T2DM). We have performed a prospective 749 T2DM or without DN. Blood samples were collected used test LCN-2 levels, function, as well biochemical parameters. CAP...
<title>Abstract</title> <bold>Purpose</bold>: High salt diet (HSD) has been considered as a risk factor for the development of metabolic disorders. However, less is known about long-term implications HSD. Therefore, aim this study was to conduct preliminary investigation into effects mice feeding with HSD on gut microbial and profiles. <bold>Methods</bold>: In study, C57BL/6J were fed 22 weeks, after which fat feces collected. The composition fecal microbiota determined using 16S rRNA gene...
Abstract OBJECTIVE Thrombospondin-2 (TSP-2) is a multifunctional matricellular glycoprotein correlated with glucose homeostasis, insulin sensitivity, and estimated glomerular filtration rate. Investigation of the association TSP-2 type 2 diabetes mellitus (T2DM) potential diagnostic value serum for detecting early diabetic kidney disease (DKD) needed. RESEARCH DESIGN AND METHODS An enzyme-linked immunosorbent assay was used detection levels in 494 Chinese T2DM subjects. The protein...
Objectives: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and stress, involved in the stepwise development of cardiovascular complications. Fibroblast growth factor 21 (FGF21) novel hepatokine regulating glucose lipid metabolism, has been linked to prediction, treatment, improvement prognosis multiple diseases (CVDs). The aim this study explore relationship between FGF21 levels vascular complications including carotid atherosclerosis (CAS)...