A5057590218- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
- Pain Management and Opioid Use
- Analytical Chemistry and Sensors
- Nausea and vomiting management
- EEG and Brain-Computer Interfaces
- Antibiotics Pharmacokinetics and Efficacy
- Veterinary Pharmacology and Anesthesia
- Epilepsy research and treatment
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Renal function and acid-base balance
- Neural dynamics and brain function
- Analytical Methods in Pharmaceuticals
- Spectroscopy Techniques in Biomedical and Chemical Research
- Heart Rate Variability and Autonomic Control
- Scientific Measurement and Uncertainty Evaluation
- Acute Kidney Injury Research
- Poisoning and overdose treatments
- Advanced Chemical Sensor Technologies
- Forensic Toxicology and Drug Analysis
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2024
Universitätsklinikum Erlangen
2008-2024
Yahoo (United Kingdom)
2020
Turku University Hospital
2015
University of Turku
2015
Committee on Publication Ethics
2015
Abstract Background Remimazolam (CNS 7056) is a new ultra–short-acting benzodiazepine for intravenous sedation and anesthesia. Its pharmacokinetics pharmacodynamics have been reported bolus administration. This study aimed to investigate the of remimazolam after continuous infusion. Methods Twenty healthy male volunteers (20 38 yr, 64 99 kg) received as infusion 5 mg/min min, 3 next 15 1 further min. Pharmacokinetics its metabolite were determined from arterial plasma concentrations....
Abstract Background Remimazolam (CNS 7056) is a new ultra-short acting benzodiazepine for IV sedation. This study aimed to investigate the electroencephalogram (EEG) pharmacodynamics of remimazolam infusion. Methods Twenty healthy male volunteers received as continuous infusion 5 mg/min min, 3 next 15 and 1 further min. Continuous EEG monitoring was performed by neurophysiologic system with electrodes placed at F3, F4, C3, C4, O1, O2, Cz, Fp1 (10/20 system) using Narcotrend Index. Sedation...
There is an ongoing debate whether opioids when used for intra-operative analgesia may enhance post-operative pain. We studied the effect of two different dosings sufentanil on morphine consumption, pain and hyperalgesia after cardiac anaesthesia.Forty-two male patients (age: 48-74 years) undergoing first-time coronary artery bypass graft surgery were randomized to one groups receiving total intravenous anaesthesia with propofol a target controlled infusion 0.4 ng/mL (group SL, n = 20) or...
The spontaneous Raman scattering technique is an excellent tool for a quantitative analysis of multi‐species gas mixtures. It noninvasive optical method species identification and phase concentration measurement active molecules, since the intensity molecule specific signal linearly dependent on concentration. Applying continuous wave (cw) laser it typically takes few seconds to capture spectrum at room temperature. Nevertheless in contrast these advantages weak major drawback. Thus, still...
GPI 15715 is a new water-soluble prodrug that hydrolyzed to release propofol. The objectives of this crossover study in volunteers were investigate the pharmacokinetics and pharmacodynamics comparison with propofol emulsion.In two separate sessions, nine healthy male (19-35 yr, 70-86 kg) received emulsion as target controlled infusion over 60 min. In first 20 min, concentration increased linearly 5 microg/ml. Subsequently, targets reduced 3 microg/ml 1.5 for min each. plasma concentrations...
Acute kidney injury (AKI) is a frequent complication after cardiopulmonary bypass, but early detection of postoperative AKI remains challenging. Protein biomarkers predict excellently in homogeneous cohorts are less reliable patients suffering from various comorbidities. We employed nuclear magnetic resonance spectroscopy prospective study 85 adult cardiac surgery to identify metabolites prognostic plasma specimens collected 24 h surgery. Postoperative stages 1-3, as defined by the Kidney...
GPI 15715 is the first water-soluble propofol prodrug that has been studied in humans. Present lipid formulations have well known undesirable properties, for example, pain on injection and increased triglyceride concentrations. We investigated whether suitable to achieve maintain moderate sedation 2 h. Six male six female volunteers received a target-controlled infusion of 15715, with an initial target concentration 1.8 microg/mL possibility adjust once after 1 Propofol concentrations,...
Bispectral analysis of the electroencephalogram (EEG) has been used for monitoring anesthesia. The estimation bicoherence allows us to determine whether a given time series represents linear random process in cases where is trivial, i.e., mere constant independent frequency. In this study, we investigated proportion EEG epochs with nontrivial during surgical anesthesia propofol and alfentanil as an indicator degree nonlinearity EEG. We reanalyzed 90 h recorded from 20 patients undergoing...
Hydromorphone is a µ-selective opioid agonist used in postoperative pain therapy. This study aimed to evaluate the pharmacokinetics of hydromorphone cardiac surgery patients during analgesia with target-controlled infusion and patient-controlled analgesia.In this study, 50 adult were enrolled receive intravenous Arterial plasma samples collected for measurements drug concentration. Population pharmacokinetic parameters estimated using nonlinear mixed-effects modeling. Results validated...
Spontaneous or evoked electrical brain activity is increasingly used to monitor general anesthesia. Previous studies investigated the variables from spontaneous electroencephalogram (EEG), acoustic (AEP), somatosensory potentials (SSEP). But, by monitoring them separately, available information simultaneous gathering could be missed. We whether combination of EEG, AEP, and SSEP shows a more discriminant power differentiate between anesthesia states than derived each measurement alone....
Patient-controlled analgesia (PCA) is a common method for postoperative pain therapy, but it characterized by large variation of plasma concentrations. PCA with target-controlled infusion (TCI-PCA) may be an alternative. In previous analysis, the authors developed pharmacokinetic model hydromorphone. this secondary investigated feasibility and efficacy TCI-PCA therapy hydromorphone.Fifty adult patients undergoing cardiac surgery were enrolled in study. Postoperatively, hydromorphone was...
The computer-aided detection of artefacts became an essential task with increasing automation quantitative electroencephalogram (EEG) analysis during anaesthesiological applications. different algorithms published so far required individual manual adjustment or have been based on limited decision criteria. In this study, we developed artificial neural networks-(ANN-)aided method for automated and EEG suppression periods. 72 hr recorded before, after anaes thesia propofol evaluated. Selected...