A5066895421- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Renal Diseases and Glomerulopathies
- Inflammasome and immune disorders
- Ocular Surface and Contact Lens
- Synthesis and biological activity
- MicroRNA in disease regulation
- Gut microbiota and health
- Ocular Diseases and Behçet’s Syndrome
- Liver Diseases and Immunity
- Immune Response and Inflammation
- Liver Disease and Transplantation
- Adenosine and Purinergic Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinal and Macular Surgery
- Supramolecular Self-Assembly in Materials
- Systemic Lupus Erythematosus Research
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Hydrogen's biological and therapeutic effects
- NF-κB Signaling Pathways
China Mobile (China)
2020-2025
Wenzhou Medical University
2019-2024
First Affiliated Hospital of Zhengzhou University
2012-2024
Hangzhou Normal University
2023-2024
Jinan University
2024
Peking University
2023
Peking University First Hospital
2023
Zhejiang Chinese Medical University
2023
Zhangqiu City People's Hospital
2014-2022
Affiliated Eye Hospital of Wenzhou Medical College
2019-2021
Cholangiocarcinoma (CCA) is an aggressive biliary epithelial tumor with limited therapeutic options and poor prognosis. Curcumin a promising active natural compound several anti-cancer properties, though its clinical uses remain hindered due to bioavailability. We recently synthesized curcumin analogs multifunctional pharmacological bioactivities enhanced Among these novel analogs, WZ26 representative molecule. However, the anti-tumor effect of against CCA unclear. In this study, we...
ABSTRACT Using LC–MS to screen and analyse the characteristics of components biological systems is a new approach study pharmacological substance basis traditional Chinese medicine, which has strong novelty in analytical science. This analyses antidepressant material Zhizichi decoction through integration strategy serum pharmacochemistry, network pharmacology immunoreactivity verification, helps overcoming limitations TCM research provided perspective for studying ZZCD. First all, blood from...
ABSTRACT In this study, Balb/c mice were subjected to chronic unpredictable mild stress (CUMS) and treated with Zhi‐zi‐chi Decoction (ZZCD). Using a hippocampal lipidomics approach that combined ultra performance liquid chromatography (UPLC)‐Q‐Exactive Orbitrap MS multivariate statistical techniques targeted metabolic pathway analysis, we identified potential lipid metabolites pathways associated depression. Meanwhile, anti‐inflammatory analyses conducted in the hippocampus of mice. The...
Abstract Non‐alcoholic fatty liver disease (NAFLD) is a progressive that can further evolve towards fibrosis and hepatocellular carcinoma in the end stage. Costunolide (Cos) natural sesquiterpene lactone exhibits both anti‐inflammatory antioxidant properties. However, therapeutic effect of Cos on NAFLD not clear. In this study, we explored potential protective mechanism NAFLD. C57BL/6 mice were fed with high‐fat diet (HFD) to induce was administered by gavage observe We demonstrated oral...
Abstract The aim of present study is to investigate whether Ferulic acid (FA), a natural polyphenol antioxidant, was able protect ARPE‑19 cells from hydrogen peroxide (H 2 O )‑induced damage, and elucidate the underlying mechanisms. Our results revealed that FA pre‐treatment for 24 hours can reverse cell loss H ‐induced ARPE‐19 via promotion proliferation prevention apoptosis, as evidenced by 5‐ethynyl‐2′‐deoxyuridine (EdU) incorporation terminal deoxynucleotidyl transferase‐mediated dUTP...
Boosting transcorneal permeability and pharmacological activity of drug poses a great challenge in the field ocular delivery. In present study, we propose drug-peptide supramolecular hydrogel based on anti-inflammatory drug, dexamethasone (Dex), Arg-Gly-Asp (RGD) motif for boosting via ligand-receptor interaction. The (Dex-SA-RGD/RGE) comprised uniform nanotube architecture formed spontaneously phosphate buffered saline (PBS, pH = 7.4) without external stimuli. Upon storage at 4 °C, 25 37 °C...
Abstract Hyperglycaemia‐induced myocardial injury promotes the induction of heart failure in diabetic patients. Impaired antioxidant capability and sustained chronic inflammation play a vital role progression cardiomyopathy (DCM). Costunolide (Cos), natural compound with anti‐inflammatory properties, has exhibited therapeutic effects various inflammatory diseases. However, Cos diabetes‐induced remains poorly understood. In this study, we investigated effect on DCM explored potential...
We hypothesized that a mixture of blackberry fruit and leaf extracts may alleviate non-alcoholic fatty liver disease (NAFLD). Rats with diet-induced NAFLD were used to test the hypothesis explore possible mechanisms. Male Sprague–Dawley rats orally administered diets 51% energy from fat 450 mg dextrin/kg bw (NAFLD-control), 50% ethanol extract (450 mg/kg bw; BL), BF), (2:1; 150 BLF), milk thistle (150 positive-control) for 12 weeks. Normal-control fed low-fat (20 En% diet) Body weight,...
Tubular cell senescence is a common biologic process and contributes to the progression of chronic kidney disease (CKD); however, molecular mechanisms regulating tubular are poorly understood. Here, we report that integrin β3 (ITGB3) expression was increased in cells positively correlated with fibrosis degree CKD patients. ITGB3 overexpression could induce p53 pathway activation secretion TGF-β, which, turn, resulted senescent profibrotic phenotype change cultured cells. Moreover, according...
Somatic and germline aberrations in homologous recombinant repair (HHR) genes are associated with increased incidence poor prognosis for prostate cancer. Through next-generation sequencing of cancer patients across all clinical states from north China, here the authors identified a somatic mutational rate 3% 3.9% HRR using 200 tumor tissues 714 blood specimens. Thus, rates were lower compared previous studies. Homologous recombination deficiency is higher risk poorer However, landscapes...
Background This research aims to explore the associations between ten candidate single nucleotide polymorphisms (SNPs) on Interleukin-6 receptor (IL6R) and Interleukin-10 (IL10) genes ankylosing spondylitis (AS) patients with or without acute anterior uveitis (AAU).