A5072554625- Educational Reforms and Innovations
- Intestinal Malrotation and Obstruction Disorders
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Antibiotic Use and Resistance
- Microtubule and mitosis dynamics
- Blood groups and transfusion
- Pancreatitis Pathology and Treatment
- Management of metastatic bone disease
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Antibiotic Resistance in Bacteria
- Neurofibromatosis and Schwannoma Cases
- Systemic Lupus Erythematosus Research
- Congenital gastrointestinal and neural anomalies
- Lymphoma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Bone and Joint Diseases
- Platelet Disorders and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Ginkgo biloba and Cashew Applications
Northwest University
2024
Shanghai Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2023
Peking Union Medical College Hospital
2017-2023
Wenzhou Medical University
2016-2023
University of South China
2023
Xiangshan County First People's Hospital
2022
Tang Du Hospital
2022
First Affiliated Hospital of Nanchang University
2016-2020
Abstract Background Resistance of colorectal cancer (CRC) cells to radiotherapy considerably contributes poor clinical outcomes CRC patients. Microarray profiling in this study revealed the differentially expressed forkhead box Q1 (FOXQ1) CRC, and thus we aimed illustrate role FOXQ1 by modulating stemness radio-resistance cells. Methods adjacent normal tissues were collected from patients, correlation between expression prognosis was analyzed. Subsequently, determined FOXQ1, sirtuin 1...
Facetectomy is an important intervention for spinal stenosis but may lead to instability. Biomechanical knowledge facetectomy can be beneficial when deciding whether fusion necessary. Therefore, the aim of this study was investigate biomechanical effect different grades facetectomy. A three-dimensional nonlinear finite element model L3–L5 constructed. The mobility and intradiscal pressure (IDP) L4-L5 standing were inside data from literature. graded on intervertebral rotation, IDP, facet...
Cholangiocarcinoma (CCA) is an aggressive biliary epithelial tumor with limited therapeutic options and poor prognosis. Curcumin a promising active natural compound several anti-cancer properties, though its clinical uses remain hindered due to bioavailability. We recently synthesized curcumin analogs multifunctional pharmacological bioactivities enhanced Among these novel analogs, WZ26 representative molecule. However, the anti-tumor effect of against CCA unclear. In this study, we...
Bladder cancer is the most common malignant tumor of urinary tract and remains one major causes death worldwide. In this study, we investigated effect mechanism Artesunate (ART), a traditional Chinese medicine, on inducing apoptosis human bladder cells. vivo antitumor activity was in rat by subcutaneous injection different concentration ART. The ART growth inhibition cells evaluated using dimethylthiazoly-2,5-diphenyltetrazolium bromide (MTT) assay flow cytometry analysis, respectively....
<h3>Background & Aims</h3> Severe acute pancreatitis can easily lead to systemic inflammatory response syndrome and death. Macrophages are known be involved in the pathophysiology of (AP), macrophage activation correlates with disease severity. In this study, we examined role ubiquitin-specific protease 25, a deubiquitinating enzyme regulator macrophages, pathogenesis AP. <h3>Methods</h3> We used L-arginine, cerulein, choline-deficient ethionine-supplemented diet–induced models AP...
The appropriate surgical treatment strategy was based on the regions of tumor invasion. There is no classification to aid surgeon in selection. A retrospective study clinical data patients who underwent resection thoracic dumbbell tumors at Neurosurgery and Thoracic Surgery Department Hospital between January 1, 2016, December 31, 2021 conducted. Patient data, images, outcome were collected. spine divided into areas A, B, C with respect line through middle intervertebral foramen...
Ceftazidime-avibactam (C-A) is a treatment option for carbapenem-resistant gram-negative bacterial (CR-GNB) infections, but little known regarding its suitability the intensive care unit (ICU). The current study aimed to analyze use of C-A critically ill patients, determine independent predictors clinical outcome and mortality explore routine dosages patients in continuous renal replacement therapy (CRRT).A single-center, retrospective observational was conducted receiving different...
Salmonella Typhimurium (S. Typhimurium) is a zoonotic pathogen posing threat to animal husbandry and public health. Due the emergence of antibiotic-resistant strains, alternative prevention control strategies are needed. Live attenuated vaccines an ideal option that provide protection against S. pandemic. To develop safe effective vaccine, double-gene mutations recommended attenuate virulence. In this study, we chose aroA luxS genes, whose deletion significantly attenuates Typhimurium’s...
To analyze the clinical and epidemiological features of patients with infantile hypertrophic pyloric stenosis (IHPS) so as to provide scientific evidence for diagnosis prevention IHPS.We performed a retrospective study infants IHPS diagnosed from 2012 2015 at Anhui Provincial Children's Hospital. Demographic characteristics data were collected.Three hundred four (264 males 40 females) studied, which 94.7% full term 75.7% bottle fed or mixed fed; 16.8% had other congenital malformations in...
Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment solid tumors. This study aimed to explore landscape FGF/FGFR alterations a large cohort cancer patients. Material Methods: formalin-fixed paraffin-embedded specimens patients who have underwent next-generation sequencing (NGS) from 2017 2019 3DMed Clinical Laboratory Inc. were included this study. Findings: Of 12,372 Chinese with more than 20 tumor types (60% male, median...
Objective: To analyze the clinical characteristics and prognosis of anorectal malformations (ARMs) explore influencing factors postoperative anal function in Anhui Province China.Methods: We performed a retrospective study ARM patients diagnosed from 2013 to 2016 at Provincial Children's Hospital. A total 332 infants with were enrolled survey. Demographic characteristic data collected. Follow-up was required evaluate after operation Logistic regression analysis used for analyzing...
Abstract: Endoreplication and maturation of the megakaryocyte (MK) may be retarded or delayed during ontogenesis. In this study, CD 34 + cells were isolated from both human fetal liver adult bone marrow incubated with thrombopoietin (TPO). The cell number, morphological characteristics, platelet‐associated antigen phenotype, stage DNA ploidy 41 examined day 0 to 12 in culture. 1) TPO stimulated proliferation (FL)‐derived a mean 73.14‐fold increase after d Adult BM‐derived increased only...
Spinal meningiomas are rare in the lumbosacral region.The best solution is complete tumor resection.However, how to preserve patient's rectum/bladder function after en bloc resection still a considerable challenge, even without spinopelvic reconstruction.The use of three-dimensional (3D) printing technique may simplify it.The final step restoration establishment rigid fixation.The purpose this article was present case treated by resection, 3D-printed prosthesis reconstruction, and fixation...
The Objective is to evaluate Elastic Stable Intrame-dullary Nailing (ESIN) fixation through the treat-ment of children’s shaft fracture tibia and fibula. From January 2007 2009, 16 cases fibula had been treated by ESIN. 15 were followed up after surgery follow-up time was 4 - 12 months (4.5 in average). results turn out that all patients’ fractures have got healed Phase I healing 10 weeks average. near joints’ activity affected extremity completely return normal. This group doesn’t show any...
Abstract Background Polymyxin B once had to exit the market due its toxicity. As antibacterial is widely used, problem of drug-resistance, especially gram-negative bacteria, has become a major threat global health. reappeared as last resort for treatment multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria. With return, use polymyxin greatly increased over time in China. The aim our study was overview actual clinical application patients with MDR XDR bacteria...