A5100607843- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Pelvic and Acetabular Injuries
- T-cell and B-cell Immunology
- Musculoskeletal pain and rehabilitation
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Scoliosis diagnosis and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Muscle Physiology and Disorders
- Respiratory viral infections research
- Management of metastatic bone disease
- Bone Tumor Diagnosis and Treatments
- Orthopaedic implants and arthroplasty
- Advanced Glycation End Products research
- Pediatric health and respiratory diseases
- Total Knee Arthroplasty Outcomes
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Neurogenetic and Muscular Disorders Research
- Asthma and respiratory diseases
- Ferroptosis and cancer prognosis
Tongji University
2016-2025
Tongji Hospital
2016-2025
Shenzhen Children's Hospital
2025
Jilin Medical University
2021-2024
Peking University People's Hospital
2011-2023
Peking University
2011-2023
Henan University
2021
Huazhong University of Science and Technology
2020
Newton Wellesley Hospital
2018-2020
Harvard University
2017-2020
Abstract A number of microRNAs (miRNAs, miRs) have been shown to play a role in skeletal muscle atrophy, but their is not completely understood. Here we show that miR-29b promotes atrophy response different atrophic stimuli cells and mouse models. myotubes differentiated from C2C12 or primary myoblasts, conversely, its inhibition attenuates induced by dexamethasone (Dex), TNF-α H 2 O treatment. Targeting IGF-1 PI3K(p85α) required for induction atrophy. In vivo , overexpression sufficient...
Abstract Increasing evidence indicates that respiratory tract microecological disorders may play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Understanding composition microbiome COPD and its relevance to immunity will help develop microbiome-based diagnostic therapeutic approaches. One hundred longitudinal sputum samples from 35 subjects with acute exacerbation (AECOPD) were analysed for bacterial using 16S ribosomal RNA amplicon sequencing technology,...
Facetectomy is an important intervention for spinal stenosis but may lead to instability. Biomechanical knowledge facetectomy can be beneficial when deciding whether fusion necessary. Therefore, the aim of this study was investigate biomechanical effect different grades facetectomy. A three-dimensional nonlinear finite element model L3–L5 constructed. The mobility and intradiscal pressure (IDP) L4-L5 standing were inside data from literature. graded on intervertebral rotation, IDP, facet...
Prenatal depression and anxiety can significantly impact a child's neurodevelopment. However, the specific timing patterns of these maternal psychological symptoms during pregnancy that influence neurodevelopment remain unclear. This study aimed to investigate associations depressive across trimesters their trajectories with neurodevelopmental outcomes in children aged 0 24 months. A total 16,229 singletons born between January 2020 December 2023 were included this prospective study....
Background: The lumbopelvic region plays a pivotal role in enabling various functional activities. This study quantified and compared the kinematic changes between healthy individuals patients with recurrent low back pain (LBP) both rested fatigued states to gain insight into adaptation mechanisms underlying variations that occur presence of these factors. Methods: Participants were divided two groups: LBP (n = 23) control groups 19). Dynamic measurements taken using biplane radiography...
Muscle atrophy is associated with negative outcomes in a variety of diseases. Identification common therapeutic target would address significant unmet clinical need. Here, we identify long non-coding RNA (lncRNA) (muscle-atrophy-associated transcript, lncMAAT) as regulator skeletal muscle atrophy. lncMAAT downregulated multiple types muscle-atrophy models both vivo (denervation, Angiotensin II [AngII], fasting, immobilization, and aging-induced atrophy) vitro (AngII, H2O2, tumor necrosis...
Abstract Background COVID-19 is still spreading rapidly around the world. In this context, how to accurately predict turning point, duration and final scale of epidemic in different countries, regions or cities key enabling decision makers public health departments formulate intervention measures deploy resources. Methods Based on surveillance data human mobility data, study predicts trends national state regional administrative units United States from July 27, 2020, January 22, 2021, by...
Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and significant cause of death worldwide. This study aimed to investigate the prognostic value clinical indicators. A prospective, multi-center was conducted (January 2017–December 2018) where patient demographic data were recorded (N = 366). The 30-day mortality rate 5.46%. Cox Regression analyses showed that serum albumin (ALB) (RR) independent variables for survival in patients with CAP....
Spinal cord injury (SCI) leads to mental abnormalities such as dementia and depression; however, the molecular mechanism of SCI-induced remains a matter debate. Asparagine endopeptidase (AEP) mediated by enhancing amyloid plaque Tau hyperphosphorylation, indicating that it played an important role in neurodegeneration. Here we revealed SCI stimulated AEP activation mice with T9 contusion injury. Activated-AEP cleaved APP Tau, resulting C586 N368 formations, consequentially accelerated Aβ...
This study documents the clinical features, incidence and prevalence of motor neuron disease (MND) in Hong Kong Chinese. Patients with MND who were alive between 1989 1992 recruited by retrieval medical records from four major hospitals Kong, referral neurologists, neurosurgeons consultants. Mortality statistics was provided Census Statistics Department. A total 84 cases identified a male preponderance 1.98:1. The average annual period 0.31/100,000 point on December 31, 1992, 0.95/100,000....
The purpose was to explore possible risk factors of facet joint violation induced by adjacent superior vertebral pedicle screw during the minimally invasive surgery transforaminal lumbar interbody fusion (MIS-TLIF). A total 69 patients with degenerative disease, who underwent MIS-TLIF were retrospectively reviewed. Postoperative computed tomography images used assess violation. correlation violations gender, age, body mass index (BMI), level, segment numbers, position insertion, straight...
SUMMARY Multiple sclerosis (MS) is strongly associated with the HLA‐Dw2 haplotype DRw15.DQw6 in Caucasoids, although relative contributions of DR and DQ loci to disease susceptibility are unknown. The situation further complicated by apparent lack an association between DR2 MS Orientals. This study examined 42 DR2‐positive chromosomes healthy Chinese 12 patients from Hong Kong, using oligonucleotide hybridizations DQA1, DQB1, DRB1, DRB5 polymerase chain reaction (PCR) products. There was...
Due to its flexibility, cable support glass curtain wall is sensitive wind loads and wind-induced dynamic response has attracted more attention recently. However, the wind-resistant study for this kind of structure mainly focuses on single-layer plane walls but rare irregular ones. In paper, an L-shaped analyzed. order truly reflect force transmission, a finite element model established ensure collaborative deformation between cable, including panel, sealant, claw connection. Time-domain...
Background. Facet joint violation (FV) was reported as variable iatrogenic damage that can be a crucial risk factor leading to the adjacent segment degeneration (ASD). “Blind” screw placement technique in minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) contributes increasing incidence of FV influenced by several potential factors. Many controversies about these factors and clinical outcomes different types patients exist, yet they have not been analyzed. Methods. 99...
Host immunity is crucial during periodontal inflammations. B cells are considered to have a function of immunoregulation, and TLRs be in this process. The present study illustrates the potential roles rules CD25+ periodontitis, especially its effect on regulating host IL-35 level Th1, Th17, Treg differentiation.The proportion local systemic cell subpopulations from periodontitis models were identified by flow cytometry. To illustrate further mechanism, cultured with different type TLR...
This study aimed to investigate whether valproic acid (VPA) pretreatment enhances the therapeutic effectiveness of mesenchymal stem cells derived from bone marrow (BMSCs) transplanted into rats with an acute spinal cord injury (SCI). BMSCs were pretreated VPA before transplantation and then intravenously injected 1 week after SCI. Before transplantation, levels CXC chemokine receptor 4 (CXCR4) expression in tested using quantitative real-time PCR Western blotting. Stromal factor-1 (SDF-1),...
Background: T helper (Th) cell cytokine imbalances have been associated with the pathophysiology of chronic obstructive pulmonary disease (COPD), including Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Clarifying profiles during COPD acute exacerbation (AE) their relationships clinical manifestations would help in understanding pathogenesis improve management. Materials Methods: Eighty seven patients admitted to hospital AEs were included this study, follow-up was conducted after...