David Higgins

ORCID: 0000-0002-3685-5495
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About
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Research Areas
  • Entrepreneurship Studies and Influences
  • Management and Organizational Studies
  • T-cell and B-cell Immunology
  • Monoclonal and Polyclonal Antibodies Research
  • Innovation and Knowledge Management
  • Family Business Performance and Succession
  • Higher Education and Employability
  • Animal health and immunology
  • Immune Cell Function and Interaction
  • Organizational Learning and Leadership
  • Glycosylation and Glycoproteins Research
  • Toxin Mechanisms and Immunotoxins
  • Herpesvirus Infections and Treatments
  • Reflective Practices in Education
  • Management and Marketing Education
  • Complement system in diseases
  • Knowledge Management and Sharing
  • Blood groups and transfusion
  • Historical and Cultural Archaeology Studies
  • Animal Virus Infections Studies
  • Transgenic Plants and Applications
  • Human Resource and Talent Management
  • Adult and Continuing Education Topics
  • Innovative Education and Learning Practices
  • RNA and protein synthesis mechanisms

University of Liverpool
1995-2024

University of Huddersfield
2009-2014

Trinity College Dublin
2014

University of Edinburgh
2006

McMaster University
1989-2002

St. Joseph’s Healthcare Hamilton
2002

Queen Mary Hospital
1990-2000

University of Hong Kong
1990-2000

University of Oxford
1995

Medical University of South Carolina
1992-1994

Eventhough entrepreneurial education is quite a new phenomenon in higher education, as field of inquiry it one the most rapidly growing areas research. However, there widespread consensus that traditional pedagogical methods learning alone are insufficient to adequately develop entrepreneurs deal with complexities running and creating innovating business opportunities. There ‘instructional methods’ As consequence need cultivate innovative ways thinking modes pedagogy fully enhance approaches...

10.1177/0971355713490619 article EN The Journal of Entrepreneurship 2013-09-01

Purpose The paper aims to explore the changing influences and relevance of passive experiential methods learning within what can be described as a new era entrepreneurial education. What still largely remains unaddressed in literature is how are entrepreneur's best educated developed manner which have direct impact on their personal business development. Design/methodology/approach suggests that action oriented, entrepreneurs not merely “doers”; they “practitioners”. An integral part being...

10.1108/03090591111128324 article EN Journal of European Industrial Training 2011-05-10

This work presents a synthesis of debate regarding taken-for-granted assumptions and challenges in entrepreneurship education, matured after developmental workshop organized to increase the research salience field. From five contributions selected, three emerge. The first is recognizing that participants’ representations about play crucial role defining goals impact education; second, integrating new perspectives conceiving into current models teaching entrepreneurship; and, lastly,...

10.1177/10564926211042222 article EN Journal of Management Inquiry 2021-11-10

IgY, the major Ab of duck (Anas platyrhynchos), exists in two secreted forms and a transmembrane (TM) form. To investigate genetic relationships multiple IgY we cloned gene encoding (upsilon) heavy chains. The chain smaller (5.7S) which lacks third fourth constant domains, results from use unique terminal exon found intron between second C region exons. Alternate pre-mRNA processing pathways also produce full-length upsilon-chain TM form, each having four domains. Although number secretory...

10.4049/jimmunol.153.12.5549 article EN The Journal of Immunology 1994-12-15

A large amount of material has been written over the years on management development relating to issues learning, training, and education. This special issue moves beyond previous studies, b...

10.1080/14623943.2011.606693 article EN Reflective Practice 2011-08-08

cDNA clones encoding the H chains of 7.8S and 5.7S IgY White Pekin duck have been isolated sequenced. The chain possesses four C region domains thus resembles chicken with which it shows, in region, 54% inferred amino acid sequence identity, complete conservation cysteine tryptophan residues. only two domains, that are virtually identical to CH1 CH2 chain. Although Southern blot genomic analysis did not resolve whether transcripts derived from one or chain-encoding genes, CH 1, 2, 3, 4 exons...

10.4049/jimmunol.149.8.2627 article EN The Journal of Immunology 1992-10-15

Purpose This paper seeks to contribute the management development debate by providing insight on dynamics of organisational learning and human interaction in SME firm. The sets out consider how a practice‐based perspective knowledge is useful this regard. Design/methodology/approach theoretical its intent adopts social constructionist view learning. Using qualitative analysis establishes review current literature highlighting centrality Findings has suggested that critical aspects within...

10.1108/14626001111106424 article EN Journal of Small Business and Enterprise Development 2011-02-22

IgA has not previously been identified in waterfowl. Studies instead revealed physical and antigenic similarities between duck bile immunoglobulin (Ig) serum IgM. Here, a differential screening approach was used to clone, from spleen library, the cDNA encoding heavy (H) chains of IgM Ig, here as IgA, occurring secretions. Phylogenetic comparisons inferred amino acid sequences entire H chain constant (C) regions individual domains that mu closest chicken (54% overall identity), alpha (50%...

10.1002/(sici)1521-4141(199803)28:03<1063::aid-immu1063>3.0.co;2-o article EN European Journal of Immunology 1998-03-01

SUMMARY Multiple sclerosis (MS) is strongly associated with the HLA‐Dw2 haplotype DRw15.DQw6 in Caucasoids, although relative contributions of DR and DQ loci to disease susceptibility are unknown. The situation further complicated by apparent lack an association between DR2 MS Orientals. This study examined 42 DR2‐positive chromosomes healthy Chinese 12 patients from Hong Kong, using oligonucleotide hybridizations DQA1, DQB1, DRB1, DRB5 polymerase chain reaction (PCR) products. There was...

10.1111/j.1744-313x.1992.tb00043.x article EN International Journal of Immunogenetics 1992-02-01

10.1016/0305-0491(90)90100-8 article EN Comparative Biochemistry and Physiology Part B Comparative Biochemistry 1990-01-01

Purpose The article aims to explore critically and contribute the development of social learning debate by providing a conceptual analysis influential meditational role played power politics in small medium‐sized enterprise (referred hereafter as SME) owner/manager's practice. One key influencing elements SME on process is that owner/manager, having both legitimacy influence Design/methodology/approach adopts constructionist perspective, which enables recognises participatory view world....

10.1108/jsbed-04-2013-0050 article EN Journal of Small Business and Enterprise Development 2013-07-31

It is stated, with increasing frequency and urgency, that Entrepreneurship Education should help society move past Business as Usual, the unsustainable development pathway which depletes communities driving climate ecological breakdown. We agree this ideal, but our lived experience suggests everyday philosophy practice of mainstream means shift will be challenging for many educators. Mainstream narratives economic growth tools such Model Canvas erase social concerns, compromising Educator in...

10.1177/25151274241277828 article EN cc-by Entrepreneurship Education and Pedagogy 2024-10-04

Summary Four types of immunoglobulin (Ig) have been identified in ducks: IgM, a secretory Ig resembling 7.8S IgG, and 5.7S IgG. Structurally antigenically the IgG resembles an F(ab')2 fragment When ducks mount serum antibody responses, sequence involvement is IgM ? Although levels increase, antigen‐binding Igs can be demonstrated, sera from repeatedly immunized commonly lack secondary activities such as agglutination, precipitation, complement fixation tissue sensitization. These...

10.1080/03079459308418916 article EN Avian Pathology 1993-06-01

Abstract Leukocyte adhesion deficiency (LAD) is caused by defects in the CD18 gene, which codes for common β2 subunit of leukocyte integrins LFA‐1, Mac‐1 and p150,95. Failure to produce a functional results defective expression all three integrins, leukocytes LAD patients have subnormal properties. Six with were studied. Patient B was homozygous carried G284S mutation. A two‐bp ( GA ) deletion at position 1256 (1256ΔGA) found cDNA patient C, who also had an abnormally large mRNA 4.3 kb....

10.1002/eji.1830250313 article EN European Journal of Immunology 1995-03-01

Five-week-old birds of resistant (N) and susceptible (P) genetic lines were inoculated with the JM strain Marek's disease (MD) virus. MD occurred only in P-line birds; one-third had died by end experiment (63 days after inoculation). Sera examined for antibodies (precipitating, virus neutralizing,and fluorescing), immunoglobulins measured. Antibodies associated immunoglobulin classes density gradient centrifugation utilization specific antisera to gowl indirect immunofluorescence....

10.1128/iai.11.1.33-41.1975 article EN Infection and Immunity 1975-01-01

10.1016/0022-1759(86)90458-8 article EN Journal of Immunological Methods 1986-02-01

Treatment of newly hatched chicks with silica by the intraperitoneal route delayed onset mortalities due to JM strain Marek's disease (MD' virus inoculated at 6 days age. During 88-day observation period fewer silica-treated died MD, but this difference was not usually statistically significant. Silica treatment had no effect on susceptibility 4-week-old birds. reduced antibody response MD but, in general, significantly. The bovine serum albumin significantly enhanced if measured indirect...

10.1128/iai.13.4.1054-1060.1976 article EN Infection and Immunity 1976-04-01

In 4 experiments, strains of chickens relatively susceptible (S-strain, P-line) or resistant (N-line, PDRC) to Marek's disease (MD) were challenged with Rous sarcoma virus (RSV) at 6-8 weeks old. RSV tumors occurred in 94-100% the birds each strain, but number that regressed during 40-46-day experiment varied from 7% (S-strain) 91% (PDRC). The N-line and P-line birds, derived a random-bred flock selection only for susceptibility resistance MD, their about equal rates (respectively 59 65%)....

10.2307/1589072 article EN Avian Diseases 1975-07-01
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