A5012138461- Photodynamic Therapy Research Studies
- Oral microbiology and periodontitis research
- Nanoplatforms for cancer theranostics
- Ocular Infections and Treatments
- Periodontal Regeneration and Treatments
- Oral Health Pathology and Treatment
- Immune Response and Inflammation
- dental development and anomalies
- Endodontics and Root Canal Treatments
- MicroRNA in disease regulation
- Dental Trauma and Treatments
- Inflammasome and immune disorders
- Laser Applications in Dentistry and Medicine
- Bone Metabolism and Diseases
- Machine Learning in Bioinformatics
- Dental Erosion and Treatment
- Testicular diseases and treatments
- Extracellular vesicles in disease
- Heat shock proteins research
- interferon and immune responses
- Vascular Malformations and Hemangiomas
- Head and Neck Cancer Studies
- Biosensors and Analytical Detection
- Effects and risks of endocrine disrupting chemicals
- Legionella and Acanthamoeba research
Binzhou University
2025
Binzhou Medical University
2025
Harbin Medical University
2015-2024
Sanya Central Hospital
2024
Fourth Affiliated Hospital of Harbin Medical University
2014-2023
Beijing Jiaotong University
2012
Toll-like receptors (TLRs) play a key role in the innate immune responses to periodontal pathogens disease. The present study was performed determine roles of TLR2 and TLR4 signaling alveolar bone resorption, using Porphyromonas gingivalis-associated ligature-induced periodontitis model mice. Wild-type (WT), Tlr2(-/-), Tlr4(-/-) mice (8 10 weeks old) C57/BL6 background were used. Silk ligatures applied maxillary second molars presence or absence live P. gingivalis infection. Ligatures...
Background: Pathological displacement of teeth caused by periodontitis-related bone loss in patients with diabetes is often corrected orthodontic treatments. However, recovery from therapy delayed for unclear reasons. This study explored effects streptozotocin-induced rats on protein expression involved remodeling the periodontal ligament (PDL) and alveolar during tooth movement. Methods: Forty-eight Sprague-Dawley were randomly divided into two experimental groups: "normal" "diabetes" (n =...
The present study assessed effects of hyperglycemia on production proteins involved in remodeling the periodontal ligament under mechanical stress.Forty-eight Sprague-Dawley rats were randomly divided into following two groups: nondiabetic (ND) and diabetes induced (DI; n=24 each group). Diabetes was DI group by a single dose streptozotocin, saline solution injected ND group. Rats killed 1-14d after induction pressure (50g) first upper left molar. Alterations collagen type I (Col-I), MMP-1...
Microvesicles (MVs) are extracellular vesicles secreted by various cell types that involved in intercellular communication. We hypothesized human periodontal disease, the pocket epithelium releases MVs, which then modulate gene expression underlying fibroblasts to control inflammation. MVs were isolated from culture medium of gingival epithelial cells (GECs) treated with oral bacterial biofilm extract or left untreated. Biofilm treatment significantly increased MV release GECs. Mass...
Periodontitis is a common chronic inflammatory disease of periodontal tissue, mostly concentrated in people over 30 years old. Statistics show that compared with foreign countries, the prevalence periodontitis China as high 40%, and more than 90%, which must arouse our great attention. Diagnosis treatment currently rely mainly on clinical criteria, exploration etiologic criteria relatively lacking. We, therefore, have explored pathogenesis from perspective immune imbalance. By predicting...
Host immunity is crucial during periodontal inflammations. B cells are considered to have a function of immunoregulation, and TLRs be in this process. The present study illustrates the potential roles rules CD25+ periodontitis, especially its effect on regulating host IL-35 level Th1, Th17, Treg differentiation.The proportion local systemic cell subpopulations from periodontitis models were identified by flow cytometry. To illustrate further mechanism, cultured with different type TLR...
ABSTRACT In periodontal disease (PD), bacterial biofilms cause gingival inflammation, leading to bone loss. healthy individuals, αvβ6 integrin in junctional epithelium maintains anti-inflammatory transforming growth factor-β1 (TGF-β1) signaling, whereas its expression is lost individuals with PD. Bacterial suppress β6 cultured epithelial cells (GECs) by attenuating TGF-β1 an enhanced pro-inflammatory response. the present study, we show that GEC exposure induced activation of...
Objectives: The aim of this study was to perform a histological evaluation sonodynamic therapy (SDT) hematoporphyrin monomethyl ether (HMME) on artificially induced periodontal disease in rats. Methods: Submerging ligatures were placed at the subgingival region first maxillary molar Eighty rats randomly assigned into four groups: group 1 received no treatment; 2 subjected 50 µg/mL HMME alone; 3 treated with low-intensity ultrasound alone (1 W/cm ); and 4 plus irradiation MHz, 30 minutes)....
The aim of the present study was to evaluate expression inflammasome and cytokine on experimental periodontitis with super activated platelet lysate (SPL) in rats.Periodontitis induced by submerging cotton ligatures right side maxillary second molar 36 Wistar rats. rats were divided into 3 groups randomly: received no treatment (control group); local injection sterile saline (ligature+saline group) SPL (ligature+SPL group). After treatments, alveolar bone level inflammation periodontal...