A5084587844- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Algal biology and biofuel production
- Spaceflight effects on biology
- Advanced Cellulose Research Studies
- Atmospheric chemistry and aerosols
- Genetics, Aging, and Longevity in Model Organisms
- Catalysis for Biomass Conversion
- Environmental and Agricultural Sciences
- Coenzyme Q10 studies and effects
- CRISPR and Genetic Engineering
- Biochemical Acid Research Studies
- Microbial Metabolites in Food Biotechnology
- Photosynthetic Processes and Mechanisms
- Robotic Locomotion and Control
- Remote Sensing and Land Use
- CO2 Sequestration and Geologic Interactions
- Fungal Biology and Applications
- Peanut Plant Research Studies
- Fungal and yeast genetics research
- Retinal Diseases and Treatments
- Immune Response and Inflammation
- Advanced battery technologies research
- Ginseng Biological Effects and Applications
China University of Geosciences
2021-2025
Zhengzhou University
2009-2025
Fudan University
2014-2025
Fujian Normal University
2015-2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Tsinghua University
2003-2023
Guilin University of Technology
2021-2023
University of Technology
2022-2023
Aerospace Information Research Institute
2023
In this study, renewable tea waste hydrolysate was used as a sole carbon source for carotenoids and lipid production. A novel
Abstract BACKGROUND Rhodosporidium toruloides can transform carbohydrates from lignocellulosic hydrolyzate into long‐chain fatty acids that contribute to biodiesel production. However R. cannot survive in due the inhibitory effects of byproducts co‐produced by hydrolysis . RESULTS To circumvent limitation, atmospheric room temperature plasma ( ARTP ) mutagenesis was utilized obtain mutant strains M11 , M14 and M18 had strong tolerance for compounds could grow without detoxification. It...
Carbon dioxide (CO2) sequestration has garnered widespread attention as a key strategy for mitigating CO2 emissions and combating the greenhouse effect. However, mechanisms underlying interactions between CO2, siliceous minerals biological processes remain unclear. The present study explored potential impacts of different concentrations on microbial activity, environmental conditions their feedback fate CO2. A total 20 experimental was created, with variables including natural synthetic...
Neddylation is a process of attaching neuronal precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to substrates for the function modulation via enzymatic cascades involving NEDD8-activating enzyme (E1), NEDD8-conjugating (E2), and NEDD8 ligase (E3). Defective in cullin neddylation 1 (DCN1) serves as co-E3 ligase, that can simultaneously bind E2 UBE2M proteins stabilize catalytic center Cullin-Ring E3 (CRL) complex, thereby promoting neddylation. reported be activated...
Bacterial persisters exhibit noninherited antibiotic tolerance and are linked to the recalcitrance of bacterial infections. It is very urgent but also challenging develop antipersister strategies. Here, we report that 10-s freezing with liquid nitrogen dramatically enhances bactericidal action aminoglycoside antibiotics by 2 6 orders magnitude against many Gram-negative pathogens, weaker potentiation effects on Gram-positive bacteria. In particular, antibiotic-tolerant
Serotonin is a neurotransmitter that plays an essential regulatory role in numerous cognitive and behavioral functions. Recent advances synthetic biology have enabled engineering of non-natural biosynthetic pathways for serotonin production E. coli. Here, optimized heterologous pathway was engineered coli coupled with the regeneration modules endogenous vital cofactor tetrahydrobiopterin (BH4) efficient using whole-cell catalysis. Further metabolic efforts were performed to ensure adequate...
Aims: The aim of the study was to isolate endophytic fungi from Acer ginnala and screen isolates rich in gallic acid. Methods Results: After epiphytic sterilization, 145 fungal endophytes were isolated stem, annual twig seed ginnala. grouped into ten different taxa, Phomopsis sp., Neurospora Phoma Epicoccum Penicillium Alternaria Fusarium Trichoderma Cladosporium sp. a species Pleosporales Incertae Sedis, by their morphological traits ITS-rDNA sequence analysis. content yield acid 141...
The oleaginous yeast Rhodosporidium toruloides has been considered as an economical lipid producer because it transforms carbohydrates from lignocellulosic hydrolyzate into triglycerides; however, R. cannot survive in due to the inhibitors co-produced by hydrolysis. We have previously reported a plasma mutagenesis-generated mutant strain M18 that had strong tolerance for stress environments of hydrolyzate. Here, we applied transcriptomic and proteomic approaches analyze global metabolic...
Several solvents and ionic liquids, namely formic acid (Formiline process), concentrated phosphoric (CPA), N-methylmorpholine-N-oxide (NMMO) 1-allyl-3-methylimidazolium chloride ([AMIM]Cl), were used to pretreat wheat straw in order increase cellulose digestibility for ethanol production. When being directly the raw under corresponding optimized conditions, improvement of hydrolyzability followed CPA > Formiline NMMO [AMIM]Cl. However, when pretreated (delignified) substrates further...
Indole-3-acetic acid (IAA) is a critical plant hormone that regulates cell division, development, and metabolism. IAA synthesis in plants plant-associated microorganisms cannot fulfill the requirement for large-scale agricultural production. Here, two novel biosynthesis pathways, tryptamine (TAM) indole-3-acetamide (IAM), were developed production by whole-cell catalysis de novo an engineered Escherichia coli MG1655. When 10 g/L l-tryptophan was used as substrate, MIA-6 strain containing...
Lignocellulose is an abundant waste resource and has been considered as a promising material for production of biofuels or other valuable bio-products. Currently, one the major bottlenecks in economic utilization lignocellulosic materials cost-efficiency converting lignocellulose into soluble sugars fermentation. One way to address this problem seek superior degradation enzymes further improve current yields lignocellulases. In present study, capacity thermophilic fungus Chaetomium...
Hydrolysis of lignocellulosic biomass is widely recognized as the most commonly used pretreatment method. The presence formate and acetate, which constitute a notable proportion inhibitory compounds in hydrolysate, hinders their efficient utilization carbon source. Herein, we performed metabolic engineering on E. coli strains by introducing heterologous RuMP pathway increasing intracellular pools essential cofactors NADPH ATP to achieve assimilation enhance acetate assimilation,...
Solid-state Li metal batteries equipped with polymer electrolytes are highly coveted for their flexibility and remarkable energy density; however, advancement is hindered by limited ionic conductivity poor interfacial stability. Herein, we report that protein additives can significantly improve the performance of poly(ethylene oxide)-based solid elucidate ion-conducting mechanism comparing proteins different charged groups (CGs). Positive CGs anchor anions in salts to increase ion...