A5101851461- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Oral Health Pathology and Treatment
- Cell Adhesion Molecules Research
- Streptococcal Infections and Treatments
- Orthodontics and Dentofacial Orthopedics
- HIV/AIDS oral health manifestations
- Oral and gingival health research
- Inflammatory mediators and NSAID effects
- Machine Learning in Bioinformatics
- Inflammasome and immune disorders
- Dental Implant Techniques and Outcomes
- Temporomandibular Joint Disorders
Fourth Affiliated Hospital of Harbin Medical University
2017-2021
Harbin Medical University
2009-2021
University of British Columbia
2017-2018
Periodontal disease (PD) and atherosclerotic vascular (ASVD) are both chronic inflammatory diseases with a polymicrobial etiology have been epidemiologically associated. The purpose is to examine whether periodontal bacteria that infect the periodontium can also tissues enhance pre-existing early aortic lesions in LDLRnull mice. Mice were orally infected intermediate bacterial colonizer Fusobacterium nucleatum for first 12 weeks followed by late colonizers (Porphyromonas gingivalis,...
Periodontal diseases manifest by the formation of deep pockets between gingiva and teeth where multispecies bacterial biofilms flourish, causing inflammation bone loss. Epithelial cell receptor αvβ6 integrin that regulates activating anti-inflammatory cytokine transforming growth factor-β1, is highly expressed in healthy junctional epithelium connects to tooth enamel. However, its expression attenuated human periodontal disease. Moreover, Itgb6 -/- mice display increased compared wild-type...
Periodontitis is a common chronic inflammatory disease of periodontal tissue, mostly concentrated in people over 30 years old. Statistics show that compared with foreign countries, the prevalence periodontitis China as high 40%, and more than 90%, which must arouse our great attention. Diagnosis treatment currently rely mainly on clinical criteria, exploration etiologic criteria relatively lacking. We, therefore, have explored pathogenesis from perspective immune imbalance. By predicting...
ABSTRACT In periodontal disease (PD), bacterial biofilms cause gingival inflammation, leading to bone loss. healthy individuals, αvβ6 integrin in junctional epithelium maintains anti-inflammatory transforming growth factor-β1 (TGF-β1) signaling, whereas its expression is lost individuals with PD. Bacterial suppress β6 cultured epithelial cells (GECs) by attenuating TGF-β1 an enhanced pro-inflammatory response. the present study, we show that GEC exposure induced activation of...