A5024551626- melanin and skin pigmentation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dermatology and Skin Diseases
- Dermatologic Treatments and Research
- Acne and Rosacea Treatments and Effects
- Peptidase Inhibition and Analysis
- Connective Tissue Growth Factor Research
- TGF-β signaling in diseases
- Dermatological diseases and infestations
- Immune Cell Function and Interaction
- Wound Healing and Treatments
- Iron Metabolism and Disorders
- Retinal Development and Disorders
- Liver Disease Diagnosis and Treatment
- Photoreceptor and optogenetics research
- Macrophage Migration Inhibitory Factor
- Neonatal Respiratory Health Research
- CAR-T cell therapy research
- Alcohol Consumption and Health Effects
- Ginseng Biological Effects and Applications
- Toxoplasma gondii Research Studies
- Histone Deacetylase Inhibitors Research
- Galectins and Cancer Biology
- Autophagy in Disease and Therapy
- Silymarin and Mushroom Poisoning
Second Hospital of Shandong University
2024
Zhejiang University
2005-2022
Sir Run Run Shaw Hospital
2005-2022
Kunming Medical University
2020-2022
Nankai University
2020
State Key Laboratory of Medicinal Chemical Biology
2020
Tianjin International Joint Academy of Biomedicine
2020
Shanghai Ocean University
2019
Wuhan University
2015-2018
Concordia University
2018
Due to overexpression of glycyrrhetinic acid (GA) receptor in liver cancer cells, modified recombinant human serum albumin (rHSA) nanoparticles for targeting tumor cells may result increased therapeutic efficacy and decreased adverse effects therapy. In this study, doxorubicin (DOX) loaded (DOX/GA-rHSA NPs) were prepared therapy cancer. GA was covalently coupled nanoparticles, which could efficiently deliver DOX into cells. The resultant GA-rHSA NPs exhibited uniform spherical shape high...
Abstract SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered novel modulatory function of SHP2. Targeting protein with allosteric inhibitors promoted anti-tumor immunity, including enhancing T cytotoxic immune-mediated regression. Knockout using CRISPR/Cas9 gene editing showed that targeting cancer cells contributes to response. Inhibition activity augmented intrinsic IFNγ signaling resulting enhanced...
Keloids are benign skin tumours occurring during wound healing in genetically predisposed patients. They characterized by an abnormal deposition of extracellular matrix components, particularly collagen. There is uncertain evidence that transforming growth factor-beta (TGFss) involved keloid formation. Therefore we investigated the expression TGFss1, 2 and 3 their receptors keloids, hypertrophic scars normal skin. Dermal fibroblasts were obtained from punch biopsies patients with keloids...
As an active compound extracted from the Chinese herb Tripterygium wilfordii, triptolide (TP) was demonstrated to have potent antiinflammatory and immunosuppressive properties in previous studies. Recently, it has been shown that TP prevented loss of dopaminergic neurons substantia nigra rats a model Parkinson's disease, but little is known about precise neuroprotective mechanism TP. This study designed elucidate whether effect partially based on its direct inhibition inflammatory molecules...
This study presents a practical methodology to monitor the spatiotemporal characteristics of urban expansion in response rapid urbanization at provincial scale by integrating remote sensing, built-up area boundaries, spatial metrics and regression. Sixty-seven cities were investigated examine differences intensity, patterns land use efficiency conjunction with identification socio-economic indicators planning strategies. Planning proposals allocate intensity among different-sized considering...
Accumulating evidence has shown that ethanol-induced iron overload plays a crucial role in the development and progression of alcoholic liver disease. We designed present study to investigate potential protective effect quercetin, naturally occurring iron-chelating antioxidant on oxidative stress. Ethanol-incubated (100 mmol/L) rat primary hepatocytes were co-treated by quercetin µmol/L) different dose ferric nitrilotriacetate (Fe-NTA) for 24 h. When hepatic enzyme releases culture medium,...
Cryoablation combination therapy with blockade of the T-cell inhibitory receptor CTL-associated antigen-4 (CTLA-4) may augment anti-tumor immune response (ATIR).It is crucial to determine duration ATIR after cryoablation and anti-CTLA-4 antibody most appropriate treatment interval therapy.To investigate characteristics induced by therapy, we developed a prostate cancer model system test capacity anti -CTLA-4 generate ATIR.Mice were randomly assigned receive no (group A), only B), plus C), or...
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by epithelial cell damage, myofibroblast activation, and collagen deposition. Multiple studies have documented that the Wnt/β-catenin pathway aberrantly activated in IPF plays a vital role differentiation activation. Kinases such as Src initiate signaling phosphorylating β-catenin at tyrosine residues, which facilitates accumulation nucleus promotion of progression. Nintedanib has been approved for treatment...
To study the effect and mechanism of Clostridium metabolite p-Cresol sulfate (PCS) in primary biliary cholangitis (PBC).Gas chromatography-mass spectrometry (GC-MS) was used to detect differences tyrosine, phenylalanine, tryptophan, PCS, p-Cresyl glucuronide (PCG) between serum PBC patients healthy controls. In vivo experiments, mice were divided into normal control, group, tyrosine group. GC-MS PCS PCG. Serum liver inflammatory factors compared groups along with polarization Kupffer cells....
Transforming growth factor beta (TGFbeta) has been suggested to be an effective inhibitor of the increased keratinocyte proliferation in psoriasis. Three TGFbeta isoforms are described (TGFbeta1, 2 and 3), signalling via a heteromeric receptor complex TGFbetaRI TGFbetaRII. Receptor binding activates SMAD2, 3 4, which translocate into nucleus regulate TGFbeta-responsive genes. SMAD6 7 proteins represent negative feedback loop inhibiting TGFbeta-SMAD path-way. As TGFbeta1 overexpression...
BACKGROUND:Kupffer cells and natural killer (NK) has been identified as contributing factors in the pathogenesis of hepatitis, but detailed mechanism these cell types primary biliary cholangitis (PBC) is poorly understood. MATERIAL AND METHODS:In this study, polyinosinic: polycytidylic acid (poly I: C), 2-octynoic acid-bovine serum albumin (2OA-BSA) Freund's adjuvant (FA) were injected to establish a murine PBC model, from which NK Kupffer extracted isolated. The then co-cultivated designed...
Tim-3, which is expressed on a variety of innate immune cells including NK cells, plays key role in many autoimmune diseases. However, the immunomodulatory actions Tim-3 primary biliary cholangitis (PBC) remain uncertain. Using murine model PBC we evaluated expression and its ligand Gal-9 peripheral blood, liver, spleen. Additionally, studied regulation chemokine receptors (CXCR1 CXCR3) vitro. Flow cytometric analysis indicated large numbers infiltrating liver exhibited high CXCR3. Moreover,...
Background: Autophagy plays an important role in maintaining intracellular homeostasis and is essential for cell survival death. Dysfunction of autophagy has been described many autoimmune diseases but data on vitiligo are scarce. Aims: The aim this pilot study was to investigate the expression autophagy-related proteins patients with vitiligo. Methods: Western blotting used analyze microtubule-associated protein light chain 3 (LC3II/I), gene 5 (Agt5), mammalian target rapamycin (mTOR) p62...
Lower fluence of 585-nm flashlamp-pumped pulsed dye laser has been successfully used as a nonablative technique in the treatment wrinkles. The objective this study was to evaluate effect (585 nm) on production collagen and mRNA expression related gene fibroblasts vitro.Cultured were treated with (fluence 3 J/cm(2), 4 spot size 7 mm, pulse duration 450 micros). transforming growth factor (TGF)-beta1, SMAD2, SMAD3, SMAD4, SMAD7 type I procollagen alpha1, alpha2 investigated by colorimetry or...