A5081771675- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Compounds in Disease Treatment
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ubiquitin and proteasome pathways
- Chromatin Remodeling and Cancer
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Neurotoxicity Research
- 14-3-3 protein interactions
- Genetic Syndromes and Imprinting
Beijing Information Science & Technology University
2024
Zhejiang University
2012-2023
Integrated Chinese Medicine (China)
2017-2023
Baylor College of Medicine
2021
Hangzhou Red Cross Hospital
2010-2020
Zhejiang Chinese Medical University
2020
Liaoning Cancer Hospital & Institute
2020
China Medical University
2020
The Third People's Hospital of Dalian City
2020
The University of Texas MD Anderson Cancer Center
2006-2013
This study aims to characterize the gut microbiota in depressed patients with bipolar disorder (BD) compared healthy controls (HCs), examine effects of quetiapine treatment on microbiota, and explore potential as a biomarker for BD diagnosis outcome. Analysis 16S-ribosomal RNA gene sequences reveals that microbial composition diversity are significantly different between HCs. Phylum
<h3>BACKGROUND AND PURPOSE:</h3> Hemodynamics factors play an important role in the rupture of cerebral aneurysms. The purpose this study was to evaluate impact hemodynamic on MANs with 3D reconstruction model CFD simulation. <h3>MATERIALS METHODS:</h3> RDSA performed 9 pairs intracranial MANs. Each pair divided into ruptured and unruptured groups. aneurysms their parent arteries were compared. <h3>RESULTS:</h3> There a significant difference WSS at peak systole between regions group (ie,...
In the clinic selective serotonin reuptake inhibitors (SSRIs), like Fluoxetine, remain primary treatment for major depression. It has been suggested that miR-16 regulates transporters (SERT) via raphe nuclei and hippocampal responses to antidepressants. However, underlying mechanism regulatory pathways are still obtuse. Here, a chronic unpredicted mild stress (CUMS) depression model in rats was established, then intragastric Fluoxetine injections were administered duration of three weeks. An...
Triptolide (TP), one of the major active components traditional Chinese herb Tripterygium wilfordii Hook F, and 2, 4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor tetrahydrobiopterin (BH4) synthesis, have been reported to potent anti-inflammatory immunosuppressive properties. However, protective effects TP DAHP on cerebral ischemia not yet. In this study, we investigated neuroprotective in a middle artery occlusion (MCAO) rat model. Furthermore, examined whether were associated with...
Stroke is the leading cause of neurological disability in humans. Middle cerebral artery occlusion (MCAO) followed by reperfusion widely accepted to mimic stroke basic medical research. Triptolide one major active components traditional Chinese herb Tripterygium wilfordii Hook F, and has been reported have potent anti-inflammatory immunosuppressive properties. Since its preclinical effects on were still unclear, we decided study focal ischemia/reperfusion injury this study. The results...
Postpartum depression (PPD) is associated with mood disorders and elevated inflammation. Studies have evidenced the activation/inhibition of autophagy excessive activation microglia to a close relationship depression. C57 microglia-specific autophagy-deficient mice (Cx3Cr1Cre/+ATG5loxp/loxp) were employed establish chronic unpredicted mild stress model from embryonic day 7 (E7) 16 (E16). Fluoxetine was administered for 3 weeks (commencing 1 week after birth). Behavioral tests (open field,...
It has previously been demonstrated that ischemic stroke activates autophagy pathways; however, the mechanism remains unclear. The aim of this study is to further investigate role plays in cerebral ischemia. 2, 4‐diamino‐6‐hydroxy‐pyrimidine (DAHP), for its nitric oxide synthase (NOS) inhibiting neuroprotective effect, and triptolide (TP), anti‐inflammatory property, were selected administer pre middle artery occlusion (MCAO). drugs administered 12 hours prior MCAO. Both magnetic resonance...
Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes. In this study, we evaluated role HIF-1α in attenuating brain damage endothelin-1 injection. Focal cerebral ischemia mice were induced by microinjection. activator, dimethyloxalylglycine (DMOG), and inhibitor, acriflavine (ACF), used evaluate hypoxia-inducible activity during ischemia. The expression levels HIF-1α, glial...
Abstract Rhox5, the founding member of reproductive homeobox on X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes survival male germ cells. To identify Rhox5-regulated genes, we generated 15P-1 cell clones expressing physiological levels Rhox5 from stably transfected expression vector. Microarray analysis identified many genes altered response to including those encoding proteins...
As an active compound extracted from the Chinese herb Tripterygium wilfordii, triptolide (TP) was demonstrated to have potent antiinflammatory and immunosuppressive properties in previous studies. Recently, it has been shown that TP prevented loss of dopaminergic neurons substantia nigra rats a model Parkinson's disease, but little is known about precise neuroprotective mechanism TP. This study designed elucidate whether effect partially based on its direct inhibition inflammatory molecules...
Histone H1 is an abundant and essential component of chromatin whose precise role in regulating gene expression poorly understood.Here, we report that a major target H1-mediated regulation embryonic stem (ES) cells the X-linked Rhox homeobox cluster.To address underlying mechanism, examined founding member cluster-Rhox5-and found its distal promoter (Pd) loses H1, undergoes demethylation, transcriptionally activated response to loss genes ES cells.Demethylation Pd required for...
Silent information regulator 1 (SIRT1) contributes to cellular regulation. Previous studies have reported SIRT1 be abnormally expressed in the ischemic penumbra of cerebral ischemia/reperfusion (I/R) injury rat model. We investigated effect on oxygen and glucose deprivation/reperfusion (OGD/R) cell injury. Over-expressed or silenced pheochromocytoma 12 (PC12) cells were exposed an in-vitro OGD/R Western blot, TUNEL staining immunofluorescence analyses performed assess apoptosis autophagy....
Mild traumatic brain injury (mTBI), common in juveniles, has been reported to be caused by sports-related concussion. Many young children may suffer from post-concussion syndrome. mTBI, early stages of life, could play a part neuron apoptosis and degeneration, cognitive motor coordination impairment, as well dementia. Our study was aimed at further investigating the post-therapeutic efficacy rapamycin recuperation mTBI while same time metamorphosis both autophagy mitophagy mTBI. We created...
Every year, around the world, between 250000 and 500000 people suffer from spinal cord injury (SCI). This study investigated potential for poly (lactic-co-glycolic acid) (PLGA) complex inoculated with olfactory ensheathing cells (OECs) to treat in a rat model.OECs were identified by immunofluorescence based on nerve growth factor receptor (NGFR) p75. The Basso, Beattie, Bresnahan (BBB) score, together an inclined plane (IP) test used detect functional recovery. Nissl staining along luxol...