A5100462174- Muscle Physiology and Disorders
- RNA modifications and cancer
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Cancer-related gene regulation
- Microbial Community Ecology and Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Genetic and phenotypic traits in livestock
- Extracellular vesicles in disease
- High Altitude and Hypoxia
- Inflammasome and immune disorders
- S100 Proteins and Annexins
- Sesame and Sesamin Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Tissue Engineering and Regenerative Medicine
- Travel-related health issues
- Endoplasmic Reticulum Stress and Disease
- Nanoparticle-Based Drug Delivery
- Bipolar Disorder and Treatment
- Phytase and its Applications
- Methane Hydrates and Related Phenomena
Chinese Academy of Agricultural Sciences
2017-2023
Institute of Animal Sciences
2021-2023
Jiangnan University
2022-2023
Henan Normal University
2023
Second Xiangya Hospital of Central South University
2023
Central South University
2023
Chinese Institute for Brain Research
2019
Zhejiang University
2019
First Affiliated Hospital Zhejiang University
2019
Ministry of Agriculture and Rural Affairs
2019
This study aims to characterize the gut microbiota in depressed patients with bipolar disorder (BD) compared healthy controls (HCs), examine effects of quetiapine treatment on microbiota, and explore potential as a biomarker for BD diagnosis outcome. Analysis 16S-ribosomal RNA gene sequences reveals that microbial composition diversity are significantly different between HCs. Phylum
Chemical composition of secondary metabolites is great importance for quality control agricultural products. Black sesame seeds are significantly more expensive than white seeds, because it thought that black beneficial to human health seeds. However, the differences in nutrient between and still unknown. The current study examined levels different via use a novel metabolomics strategy. Using widely targeted data, we obtained structure content 557 metabolites, out which 217 were identified,...
High altitude represents some of the most extreme environments worldwide. The genetic changes underlying adaptation to such have been recently identified in multiple animals but remain unknown horses. Here, we sequence complete genome 138 domestic horses encompassing a whole altitudinal range across China uncover basis for high-altitude hypoxia. Our data set includes 65 lowland ten Chinese native breeds, 61 living at least 3,300 m above sea level seven locations along Qinghai-Tibetan...
Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment Dandan Wang,1,* Xiaowei Xu,2,* Kai Zhang,3 Bin Sun,4 Lu Wang,1 Lin Meng,1 Qilin Liu,4 Changyu Zheng,5 Bai Yang,3 Hongchen Sun1,3,6 1Department Pathology, School Hospital Stomatology, Jilin University, Changchun, People’s Republic China; 2Department Periodontology, 3State Key Laboratory Supramolecular Structure Materials, College Chemistry,...
Skeletal muscle is essential for locomotion, metabolism, and protein homeostasis in the body. Mitochondria have been considered as a key target to regulate metabolic switch during myo-genesis. The insulin-like growth factor 1 (IGF-1) signaling through AKT/mammalian of rapamycin (mTOR) pathway has well-documented role promoting regeneration, but whether it involved mitochondrial behavior function remains un-examined. In this study, we investigated effect IGF-1 on remodeling myogenic...
Two moderately halophilic marine bacterial strains of the family Rhodobacteraceae, designated ZGT108T and ZGT118T, were isolated from brine-seawater interface at Erba Deep in Red Sea (Saudi Arabia). Cells both aerobic, rod-shaped, non-motile, Gram-stain-negative. The sequence similarity 16S rRNA genes ZGT118T was 94.9 %. highest gene strain to its closest relative, Ruegeria conchae JCM 17315T, 98.9 %, while most closely related that intermedia LMG 25539T (97.7 % similarity). sizes draft...
Abstract Sepsis‐induced muscle atrophy often increases morbidity and mortality in intensive care unit (ICU) patients, yet neither therapeutic target nor optimal animal model is available for this disease. Here, by modifying the surgical strategy of cecal ligation puncture (CLP), a novel sepsis pig created that first time recapitulates whole course humans. With increased levels transcription factor zinc finger BED‐type containing 6 (ZBED6) skeletal are shown. Protection against sepsis‐induced...
ZBED6, a key transcription factor, plays an important role in skeletal muscle and organ growth. ZBED6 knockout (ZBED6-/-) leads to the upregulation of IGF2 pig mice muscle, thereby increasing mass. However, effects mechanism Zbed6 single-allele (Zbed6+/-) on remain unknown. Here, we reported that Zbed6+/- promotes growth by new potential target gene rather than Igf2 muscle. showed markedly higher mass (25%) weight ratio (18%) wild-type (WT) mice, coinciding with larger fiber area (28%)....
A Gram-stain-negative, short ovoid- to coccus-shaped, aerobic, non-flagellated, and nonmotile strain, designated WN007T, was isolated from the natural saline-alkali wetland soil. Growth occurred at 10-45 °C (optimum 33-37 °C), pH 6.5-10.0 (optimum, 7.5-8.0) with 0-15 % (w/v) NaCl 2-4 NaCl). Catalase- oxidase-positive. comparison of 16S rRNA gene sequence WN007T showed highest similarities Paracoccus chinensis (97.5 %) niistensis (97.4 %). The major respiratory quinone strain Q10 fatty acid...
Atrazine (ATR) is extensively used worldwide as an herbicide, with a global ecological influence. The widespread distribution of herbicides may be one the possible reasons for decline in amphibian population. acute toxicity and potential toxicological mechanisms ATR on immune system frogs are not well-understood. In this study, Pelophylax nigromaculata was experimental carrier exposed to 0, 1, 10, 100, 1000 μg/L solutions 14 days, resulting significant decrease viability their lymphocytes....
A Gram-stain-negative, aerobic, non-flagellated, non-motile bacterium, designated strain WRN-8T, was isolated from marine sediment of the Yellow Sea, China (36° 5' 33'' N, 121° 20' 37'' E). Colonies WRN-8T were 0.2-0.3 µm wide, 2.1-2.8 long, catalase-positive and oxidase-positive. on agar solid media circular, wet, smooth, light yellow approximately 1.3 mm in diameter. Growth occurred optimally at 33-37 °C, pH 7.0-7.5 presence 2-4 % NaCl (w/v). Phylogenetic analysis 16S rRNA gene indicated...
ZBED6 (zinc finger BED domain containing protein 6) is a transcription factor unique to placental mammals and its interaction with the IGF2 (insulin-like growth 2) locus plays prominent role in regulation of postnatal skeletal muscle growth. Here, we generated lean Bama miniature pigs by generating ZBED6-knockout (ZBED6-/-) investigated mechanism underlying internal organs mammals. ZBED6-/- show markedly higher mass, mass rate, larger fiber area heavier (heart liver) than wild-type (WT)...
The mutation of insulin-like growth factor 2 (IGF2 mutation) that a single-nucleotide substitution (G→A) in the third intron IGF2 abrogates interaction with zinc finger BED-type containing 6 (ZBED6) and leads to increased muscle mass pigs. knock-in KI) ZBED6 knockout (ZBED6 KO) lead changes expression increase mice Long noncoding RNAs (lncRNAs) may participate numerous biological processes, including skeletal development. However, role ZBED6-lncRNA axis development is poorly characterized.In...
Chrysanthemum morifolium Ramat. ‘Huaihuang’ is a traditional Chinese medicinal plant. However, black spot disease caused by Alternaria sp., typical necrotrophic fungus, has serious damaging influence on the field growth, yield, and quality of ‘Huaiju 2#’ being bred from ‘Huaihuang’, shows resistance to sp. bHLH transcription factor been widely studied because their functions in growth development, signal transduction, abiotic stress. function biotic stress rarely studied. To characterize...
The purpose of this study was to investigate the expression miRNA-223 and NLRP3 in IgA patients intervention traditional Chinese medicine (TCM), so as realize basic pathological changes patients, patients' body indexes before after treatment TCM.Firstly, according clinical data, with nephropathy were divided into different groups their changes. After that, chemical sections staining steps immune kidney carried out. Immunohistochemical pv-9000 two-step method used stain it. By method, genes...
The main function of adipocyte fatty acid-binding protein (A‑FABP) is to regulate acid metabolism as its molecular chaperone. clinical significance A‑FABP in hypoxic-ischemic brain damage (HIBD) neonates not yet clear. Free (FFA) cerebral cortex increases along with hypoxia ischemia degree. Thus, we aimed investigate whether FFA can induce A-FABP expression and elevate the serum level HIBD neonates. In present study, 42 were selected including 11 cases mild, 16 moderate 15 severe. was...
Abstract Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to regulate gene expression by oxidizing 5-methylcytosine 5-hydroxymethylcytosine, functioning as essential epigenetic regulator in various biological processes. However, the regulation and function of TET2 adipocytes during obesity are poorly understood. In this study, we demonstrate leptin, a key adipokine mammalian energy homeostasis regulation, suppresses adipocyte levels via JAK2-STAT3 signaling....
The ZBED6 gene is a transcription factor that regulates the expression of IGF2 and affects muscle growth development. However, its effect on development heart still unknown. Emerging evidence suggests long noncoding RNAs (lncRNAs) can regulate genes at epigenetic, transcriptional, posttranscriptional levels play an important role in eukaryotes. To investigate function cardiac pigs, we constructed profiles mRNAs lncRNAs myocardial tissue obtained from Bama Xiang pigs knockout group (ZBED6-KO)...
Abstract Background Research on cashmere growth has a significant effect the production of and profound influence goat breeding. Whole-genome sequencing is powerful platform to rapidly gain novel insights into identification genetic mechanisms underlying fiber growth. Results In this study, we generated whole-genome sequences 115 domestic goats from China, Nepal Pakistan, including 51 64 non-cashmere goats. We found genetically distinct clusters according their geographic locations but...
Abstract BackgroundResearch on cashmere growth has a significant effect the production of and profound influence goat breeding. Whole-genome sequencing is powerful platform to rapidly gain novel insights into identification genetic mechanisms underlying fiber growth. ResultsIn this study, we generated whole-genome sequences 115 domestic goats from China, Nepal Pakistan, including 51 64 non-cashmere goats. We found genetically distinct clusters according their geographic locations but...
Transcription factor zinc-finger BED domain-containing protein 6 (ZBED6) is unique to placental mammals and regulates insulin-like growth 2 (IGF2) expression, which lead muscle growth. However, the effect of ZBED6 on spleen still elusive. In this study, we explored regulation growth, results showed knockout (ZBED6 KO) pigs had heavier spleens than wild-type (WT) pigs. To analyze mechanism increased weight in KO pigs, long noncoding RNAs (lncRNAs) mRNAs samples (WT:ZBED6 = 3:3) were analyzed...
Objective To investigate the effects of N-Methyl-D-Aspartate receptor (NMDAR) inhibition on acute myocardial infarction (AMI) in respect reduction incidence ventricular arrhythmias (VAs) and infarct size a rat model order to provide experimental evidence for prevention treatment AMI. Methods A total 45 Sprague-Dawley rats were randomly (random number) divided into Sham group, AMI group plus MK801 (a specific inhibitor NMDAR) (treatment group). The ligation left anterior descending...