A5101530604- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- Metabolism and Genetic Disorders
- Reproductive Biology and Fertility
- ATP Synthase and ATPases Research
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Proteoglycans and glycosaminoglycans research
- Respiratory Support and Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Pulmonary Hypertension Research and Treatments
- Sulfur Compounds in Biology
- Traditional Chinese Medicine Studies
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Alzheimer's disease research and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Anesthesia and Neurotoxicity Research
- Heme Oxygenase-1 and Carbon Monoxide
- Organ Transplantation Techniques and Outcomes
- Synthesis of Organic Compounds
Chongqing Medical University
2008-2025
Sinocelltech Group (China)
2022-2025
Brookhaven National Laboratory
2024
Jiangsu Academy of Agricultural Sciences
2022-2024
Guangdong Medical College
2001-2024
Luye Pharma (China)
2024
Northwest University
2024
Washington University in St. Louis
2023-2024
Jiujiang University
2023
Xijing Hospital
2013-2023
<h3>Importance</h3> Several respiratory support techniques are available to minimize the use of invasive mechanical ventilation (IMV) in preterm neonates. It is unknown whether noninvasive high-frequency oscillatory (NHFOV) more efficacious than nasal continuous positive airway pressure (NCPAP) or intermittent (NIPPV) neonates after their first extubation. <h3>Objective</h3> To test hypothesis that NHFOV NCPAP NIPPV reducing IMV extubation and until neonatal intensive care unit discharge...
Abstract In lactating mothers, the high calcium (Ca 2+ ) demand for milk production triggers significant bone loss 1 . Although oestrogen normally counteracts excessive resorption by promoting formation, this sex steroid drops precipitously during postpartum period. Here we report that brain-derived cellular communication network factor 3 (CCN3) secreted from KISS1 neurons of arcuate nucleus (ARC fills void and functions as a potent osteoanabolic to build in females. We began showing our...
Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol. Tetramer destabilization misfolding of the released monomers result in TTR aggregation, leading to its deposition as amyloid primarily heart peripheral nervous system. Over 100 mutations have been linked familial forms amyloidosis. Considerable effort has devoted study aggregation these mutants, although majority TTR-related amyloidosis represented by sporadic cases due otherwise stable wild-type (WT)...
Feeding of rapeseed (canola) oil with a high erucic acid concentration is known to cause hepatic steatosis in animals. Mitochondrial fatty oxidation plays central role liver lipid homeostasis, so it possible that metabolism might decrease mitochondrial oxidation. However, the precise mechanistic relationship between levels and unclear. Using male Sprague–Dawley rats, along biochemical molecular biology approaches, we report here peroxisomal β-oxidation stimulates malonyl-CoA formation...
The NASONE (Nasal Oscillation Post-Extubation) trial showed that noninvasive high-frequency oscillatory ventilation (NHFOV) slightly reduces the duration of invasive mechanical (IMV) in preterm infants, whereas NHFOV and intermittent positive pressure (NIPPV) result fewer reintubations than nasal continuous airway (NCPAP). It is unknown whether similarly effective extremely neonates or those with more severe respiratory failure (based on previous CO2 levels).To clarify better NIPPV NCPAP...
Abstract X-ray computed tomography (XCT) and fluorescence (XRF) imaging are two non-invasive techniques to study cellular structures chemical element distributions, respectively. However, correlative for the same cell have yet be routinely realized due challenges in sample preparation radiation damage. Here we report an integrated experimental computational workflow achieving multi-modality of a single cell. The method consists radiation-resistant single-cell samples using live-cell...
Introduction: Stroke etiology could influence treatment decisions. This study aims to evaluate the efficacy and safety of bridging thrombolysis (BT) compared direct endovascular (EVT) in patients with basilar artery occlusion (BAO), stratified by stroke subtype. Methods: Data were collected from PERSIST multicenter retrospective registry, enrolling acute symptomatic BAO treated EVT. subtypes classified based on TOAST criteria into large-artery atherosclerosis (LAA), cardioembolism (CE),...
Elderly type 2 diabetes mellitus (T2DM) patients complicated with heart failure (HF) exhibit a high rate of 30-day readmission. Predictive models have been suggested as tools for identifying high-risk patients. Thus, we aimed to develop and validate predictive model using multicenter electronic medical records (EMRs) data estimate the risk readmission in elderly T2DM HF. EMRs HF from five tertiary hospitals, spanning 2012 2023, were utilized model. The evaluated holdout area under receiver...
Background/Objectives: Finotonlimab (SCTI10A) is a humanized anti-PD-1 antibody tested in Phase III trials for several solid tumor types. Methods: This study characterized the vitro and vivo efficacy, Fc-mediated effector function, non-clinical PK/PD properties of finotonlimab. Results: The results demonstrated that finotonlimab effective stimulating human T cell function exhibits marked antitumor efficacy using both PD-1-humanized PBMC-reconstructed mouse models. Additionally, exhibited...
Abstract Fucosylated chondroitin sulfate (FuCS) is a structurally distinct glycosaminoglycan, and its oligosaccharides exhibit excellent anticoagulant activity with lower risks of adverse effects bleeding. Herein we report facile approach to the synthesis FuCS hexa‐ nonasaccharides on basis enzymatic degradation over 12 linear steps. As compared clinical low‐molecular‐weight heparin drug (enoxaparin), nonasaccharide synthesized in this study displayed similar APTT selective intrinsic factor...
The increased cases of hyperlipemia in China and the crucial role PM2.5 inducing promoting cardiovascular diseases have attracting more researchers' attention. However, effects mechanisms on system hyperlipidemia people are still unclear. In this study, mice model was established by high-fat diet. Then we exposed these to or saline explore underling mechanism cardiac injury mice. susceptible heart damage caused exposure. participation oxidative stress, cell apoptosis Ca2+ related could be...
Remote ischemic postconditioning (RIPC) has been proven to be a promising protective method for brain damage caused by transient focal ischemia/reperfusion (I/R) injury. However, the underlying mechanism of RIPC remains elusive. To address whether protects against regulating TLR4 and NF-κB pathway, I/R rat (SD) model induced 1 h middle cerebral artery occlusion was used in this study. treatment generated three cycles 10 min release bilateral hind femoral arteries. The Garcia JH score...