A5014678467- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Mitochondrial Function and Pathology
- High Altitude and Hypoxia
- Mechanical Circulatory Support Devices
- Cancer, Hypoxia, and Metabolism
- Neonatal and fetal brain pathology
- Retinopathy of Prematurity Studies
- Congenital Heart Disease Studies
- Infant Nutrition and Health
- Neonatal Health and Biochemistry
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
- Tracheal and airway disorders
- Infant Development and Preterm Care
- COVID-19 Impact on Reproduction
- Respiratory viral infections research
- Neonatal and Maternal Infections
- Cardiac Arrest and Resuscitation
- MicroRNA in disease regulation
- Preterm Birth and Chorioamnionitis
- Sepsis Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
Chinese PLA General Hospital
2020-2024
Southern Medical University
2014-2024
Nanfang Hospital
2024
Weatherford College
2023
Chinese People's Liberation Army
2016-2023
Bayi Children's Hospital
2013-2022
Dalian Medical University
2021
First Affiliated Hospital of Dalian Medical University
2021
Second Military Medical University
2019
Boston Children's Hospital
2014
<h3>Importance</h3> Several respiratory support techniques are available to minimize the use of invasive mechanical ventilation (IMV) in preterm neonates. It is unknown whether noninvasive high-frequency oscillatory (NHFOV) more efficacious than nasal continuous positive airway pressure (NCPAP) or intermittent (NIPPV) neonates after their first extubation. <h3>Objective</h3> To test hypothesis that NHFOV NCPAP NIPPV reducing IMV extubation and until neonatal intensive care unit discharge...
The NASONE (Nasal Oscillation Post-Extubation) trial showed that noninvasive high-frequency oscillatory ventilation (NHFOV) slightly reduces the duration of invasive mechanical (IMV) in preterm infants, whereas NHFOV and intermittent positive pressure (NIPPV) result fewer reintubations than nasal continuous airway (NCPAP). It is unknown whether similarly effective extremely neonates or those with more severe respiratory failure (based on previous CO2 levels).To clarify better NIPPV NCPAP...
Neutrophil extracellular traps (NETs) is the key means for neutrophils to resist bacterial invasion. Sepsis a systemic inflammatory response syndrome caused by infection. In our study, qRT-PCR was used detect gene expression in neutrophils, Western blot protein mouse tissues and flow cytometry purity of whole blood immunofluorescence NETs formation. this we analyzed formation patients with sepsis. The results showed that large number appeared. And GPR109A sepsis significantly up regulated....
To investigate the incidence of Retinopathy Prematurity (ROP) in Beijing, North China, and to evaluate effectiveness different ROP screening criteria, we conducted a prospective cohort study single-neonatal intensive care unit (NICU). A total 2997 premature infants with birth weight (BW) ≤ 2000 g and/or gestational age (GA) 34 weeks had completed screening. was diagnosed 356 (11.9%) infants. The mean GA 30.46 ± 1.98 BW 1477.35 371.29 g. Of 59 (2.0%) receiving treatment, 29.37 2.10 weeks,...
Abstract Background Circular RNA circFADS2 plays protective roles in LPS-induced inflammation, which promotes sepsis, suggesting its involvement sepsis. Methods Expression of circFADS2, mature miR-15a-5p, and miR-15a-5p precursor plasma samples from sepsis patients healthy controls was determined by RT-qPCR. The expression vector transfected lung cells, followed the measurement levels to study role maturation. Cell apoptosis analyzed cell assay. Results CircFADS2 upregulated inversely...
Abstract Kangaroo mother care has reduced mortality and morbidity in preterm low birth weight infants many benefits, such as promoting breastfeeding. Based on the current evidence China international, we developed a clinical practice guideline for kangaroo using Grading of Recommendations, Assessment, Development Evaluation proposed 34 recommendations 20 key questions. Our goal is to promote appropriate implementation practice.
Platelet transfusion is commonly performed in infants to correct severe thrombocytopenia or prevent bleeding. Exploring the associations of platelet transfusion, count (PC), and mean volume (MPV) with intraventricular hemorrhage (IVH) in-hospital mortality preterm can provide evidence for establishment future practices.To evaluate PC, MPV IVH explore whether transfusion-associated risks vary PC levels at time transfusion.This retrospective cohort study included who were transferred neonatal...
Abstract Objective To compare post-treatment recurrence between ranibizumab injection and l aser photocoagulation (LP) for type 1 retinopathy of prematurity (ROP), explore the associated risk factors. Methods The clinical data ROP infants treated with LP or in a NICU China from October 2007 to November 2021 were retrospectively analyzed compared, such as general condition, degree ROP, therapeutic effectiveness recurrence. dependent variable was after treatment. Univariate regression analysis...
High-flow nasal cannula (HFNC) oxygen therapy, which is important in noninvasive respiratory support, increasingly being used critically ill neonates with failure because it comfortable, easy to setup, and has a low incidence of trauma. The advantages, indications, risks HFNC have been the focus research recent years, resulting development application. Based on current evidence, we developed guidelines for using Grading Recommendations Assessment, Development Evaluation (GRADE). were...
In our study, the reference intervals of serum thyroid hormones were established in 247 hospitalized preterm infants from 28 to 36 weeks gestation at 8-15 postnatal days. The triiodothyronine (T3), free (FT3), thyroxine (T4), (FT4), and thyrotropin (TSH).Electrochemiluminescence immunoassay was used examine hormone levels samples infants, who grouped on sampling by gestational age. SPSS 16.0 calculate population-based intervals, comparison manufacturer's suggested intervals.Kruskal-Wallis H...
Background: Although the expression of toll-like receptors (TLRs) on different types human mesenchymal stem cells (hMSCs) has recently been reported, controversy remains regarding presence TLR4 as well its engagement and impact Wharton's jelly-derived MSCs (hWJ-MSCs). Methods: In present study, role in hWJ-MSCs was investigated using a model lipopolysaccharide (LPS). Proliferation, apoptosis, paracrine factors primed with LPS were analysed. Results: The high at RNA level but very low protein...
Neonatal diseases are a significant threat to global public health, affecting the homeostasis and well-being of patients reflecting status of, challenges to, regional, national, healthcare systems. This study sought investigate how disease spectrum observed among neonatal inpatients changed after onset coronavirus 2019 (COVID-19) pandemic.
Abstract Small interfering RNAs (siRNAs) directed against poliovirus (PV) and other viruses effectively inhibit viral replication have been developed as antiviral agents. Here, we demonstrate that a specific siRNA targeting the region between nucleotides 100–125 (siRNA-100) from 5′-untranslated (5′-UTR) of PV plays critical role in inhibiting replication. Our data siRNA-100 treatment can greatly reduce titers, resulting up-regulation host microRNA-7 (miR-7), which turn, leads to enhance...
Bronchopulmonary dysplasia (BPD) is a common pulmonary complication observed in preterm infants that composed of multifactorial pathogenesis. Current strategies, albeit successful moderately reducing morbidity and mortality BPD, failed to draw overall satisfactory conclusion. Here, using typical mouse model mimicking hallmarks we revealed both cord blood-derived mononuclear cells (CB-MNCs) umbilical cord-derived mesenchymal stem (UC-MSCs) are efficient alleviating BPD. Notably, infusion...