A5060447717- Air Quality and Health Impacts
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Climate Change and Health Impacts
- Animal Behavior and Reproduction
- Animal Ecology and Behavior Studies
- Stress Responses and Cortisol
- Advanced MRI Techniques and Applications
- Receptor Mechanisms and Signaling
- Advanced Neuroimaging Techniques and Applications
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune and Inflammatory Disorders
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Inflammasome and immune disorders
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Mast cells and histamine
- Air Quality Monitoring and Forecasting
- Inflammation biomarkers and pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traditional Chinese Medicine Studies
Chinese PLA General Hospital
2025
Radboud University Nijmegen
2020-2023
Radboud University Medical Center
2020-2023
Dalian Medical University
2018-2023
Allen Institute for Brain Science
2023
Affiliated Hospital of Jiangxi College of TCM
2007
Abstract Background Crohn’s disease (CD) poses a significant risk of postoperative recurrence (POR), complicating management, and data on the use Ustekinumab (UST) in CD patients China is limited. This study evaluated efficacy safety UST preventing POR. Methods multicenter, retrospective observational involved from four Chinese tertiary hospitals, all whom had at least two high-risk factors. Patients who failed anti-TNF-α treatments or Vedolizumab switched to as non-first-line therapy, while...
PM2.5, a main particulate air pollutant, poses serious hazard to human health. The exposure PM2.5 increases mortality and morbidity of many respiratory diseases such as asthma, chronic obstructive pulmonary even lung cancer. contribution reactive oxygen species (ROS) in the PM2.5-induced acute injury process was confirmed our previous research, but molecular mechanism based for it remains unclarified. In this ROS-induced after explored vivo vitro. study indicated that N-acetyl-L-cysteine...
The increased cases of hyperlipemia in China and the crucial role PM2.5 inducing promoting cardiovascular diseases have attracting more researchers' attention. However, effects mechanisms on system hyperlipidemia people are still unclear. In this study, mice model was established by high-fat diet. Then we exposed these to or saline explore underling mechanism cardiac injury mice. susceptible heart damage caused exposure. participation oxidative stress, cell apoptosis Ca2+ related could be...
The central serotoninergic system is critical for stress responsivity and social behavior, its dysregulations have been centrally implicated in virtually all neuropsychiatric disorders. Genetic serotonin depletion animal models could provide a tool to elucidate the causes mechanisms of diseases develop new treatment approaches. Previously, mice lacking tryptophan hydroxylase 2 (Tph2) developed, showing altered behaviors neurotransmission. However, effect congenital deficiency on emotional...
Exposure to particulate matters with diameters below 2.5 µm (PM2.5) is considered a major risk factor for cardiovascular diseases (CVDs). The closest associations between PM2.5 and CVDs have been observed in hyperbetalipoproteinemia cases, although the detailed underpinning mechanism remains undefined. In this work, hyperlipidemic mice H9C2 cells were used examine effects of on myocardial injury their underlying mechanisms. results revealed that exposure caused severe damage high-fat mouse...
Abstract Epidemiological researches have demonstrated the relationship between PM 2.5 exposure and increased morbidity mortality of cardiovascular injury. However, no effective therapeutic method was established. The purpose this study is to investigate effect acute on mice heart tissue explore effects compound essential oils (CEOs) in model. In study, after were exposed intratracheally, some obvious histopathological changes as well great alterations proinflammatory cytokines observed...
Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...
Animals need to respond threats avoid danger and approach rewards. In nature, these responses did not evolve alone but are always accompanied by motivational conflict. A semi-naturalistic threat imminence continuum model models the approach-avoidance conflict is able integrate multiple behaviors into a single paradigm. However, its comprehensive application hampered lack of detailed protocol data about some fundamental factors including sex, age, level. Here, we modified previously...
ABSTRACT The central serotoninergic system is critical for stress responsivity and social behavior, its dysregulations has been centrally implicated in virtually all neuropsychiatric disorders. Genetic serotonin depletion animal models could provide a tool to elucidate the causes mechanisms of diseases develop new treatment approaches. Previously mice lacking tryptophan hydroxylase 2 (Tph2) have developed, showing altered behaviors neurotransmission. However, effect congenital deficiency on...
Summary Animals display defensive behaviors in response to threats avoid danger and approach rewards. In nature, these responses did not evolve alone but are always accompanied by motivational conflict. A semi-naturalistic threat imminence continuum model models the approach-avoidance conflict is able integrate multiple into a single paradigm. However, its comprehensive application hampered lack of detailed protocol data about some fundamental factors including sex, age, level. Here, we...
Abstract Background: PM 2.5 , the main particulate air pollutant, poses serious hazard to human health. Alzheimer's disease (AD) is a major neurodegenerative characterized by amyloid plaques and neurofibrillary tangles. Recent studies reported that could promote AD-like pathologies in brain. However, mechanism of -induced changes still unclear more investigations are needed for further understanding. Methods: In this study, we established experimental model long-term exposure with young/old...