A5081495420- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Atomic and Subatomic Physics Research
- Complex Systems and Time Series Analysis
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Neural Networks and Applications
- Time Series Analysis and Forecasting
- Brain Tumor Detection and Classification
- Thermoregulation and physiological responses
- Photoreceptor and optogenetics research
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neuropharmacology Research
University of Münster
2023-2024
University Hospital Münster
2019-2022
Imaging Center
2022
Functional blood-oxygenation-level-dependent (BOLD) MRI provides a brain-wide readout that depends on the hemodynamic response to neuronal activity. Diffusion fMRI has been proposed as an alternative BOLD and postulated directly rely These complementary functional readouts are versatile tools be combined with optogenetic stimulation investigate networks of brain. The cell-specificity temporal precision manipulations promise enable further investigation origin signals. signal characteristics...
For a reliable estimation of neuronal activation based on BOLD fMRI measurements an accurate model the hemodynamic response is essential. Since large part basic neuroscience research small animal data, it necessary to characterize function (HRF) which optimized for animals. Therefore, we have determined and investigated HRFs rats obtained under variety experimental conditions in primary somatosensory cortex. Measurements were performed animals different sex strain, anesthetics, with without...
Small animal fMRI is an essential part of translational research in the cognitive neurosciences. Due to small dimensions and physiology preclinical prone artifacts that may lead misinterpretation data. To reach unbiased conclusions, it is, therefore, crucial identify potential sources experimental noise develop correction methods for contributions cannot be avoided such as physiological noise. Aim this study was assess origin prevalence hemodynamic oscillations (HDO) rat, well their impact...
BOLD fMRI has become a prevalent method to study cerebral sensory processing in rodent disease models, including pain and mechanical hypersensitivity. data analysis is frequently combined with general-linear-model (GLM) -based analysis, which uses the convolution of hemodynamic response function (HRF) stimulus paradigm. However, several studies indicated that HRF differs across species, sexes, brain structures, experimental factors, stimulation modalities or anesthesia, hence might strongly...
Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...
Resting state-fMRI was performed to explore brain networks in Genetic Absence Epilepsy Rats from Strasbourg and nonepileptic controls (NEC) during monitoring of the state by simultaneous optical Ca2+-recordings. Graph theoretical analysis allowed for identification acute chronic network changes revealed preserved small world topology before after seizure onset. The most prominent change organization seizures segregation cortical regions remaining brain. Stronger connections between thalamic...
Introduction Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent a model of genetic generalized epilepsy. The present longitudinal study in GAERS and age-matched non-epileptic controls (NEC) aimed to characterize the epileptic brain network using two functional measures, resting state-functional magnetic resonance imaging (rs-fMRI) manganese-enhanced MRI (MEMRI) combined with morphometry, investigate potential alterations, following long-term seizure activity. Methods Repeated...
Significance: Fluorescence resonance energy transfer (FRET) sensors offer enormous benefits when studying neurophysiology through confocal microscopy. Yet, their use for fiber-based in vivo recordings is hampered by massive confounding effects and has therefore been scarcely reported. Aim: We aim to investigate whether lactate the rodent brain are feasible with FRET implement a correction algorithm predominant hemodynamic artifact. Approach: performed of (Laconic) calcium (Twitch-2B)...
Time series analysis of heterogeneous preclinical functional magnetic resonance imaging (fMRI) studies poses challenges due to data volume and method heterogeneity. Recent advances in machine learning (ML) artificial intelligence (AI) allow for addressing such complex datasets. These approaches can uncover patterns, including temporal kinetics, within blood-oxygen-level-dependent (BOLD) time with a reduced workload. However, the typically low resolution signal-to-noise ratio (SNR) fMRI have...
Functional Magnetic Resonance Imaging (fMRI) in rodents is pivotal for understanding the mechanisms underlying Blood Oxygen Level-Dependent (BOLD) signals and phenotyping animal models of disorders, amongst other applications. Despite its growing use, comparing rodent fMRI results across different research sites remains challenging due to variations experimental protocols. Here, we aggregated analyzed 22 sensory-evoked rat datasets from 12 imaging centers, totaling scans 220 rats, assess...
Motivation: We address the need for standardization and collaboration in rat sensory-evoked fMRI by providing evidence-based recommendations open-access datasets, fostering community growth. Goal(s): aim to assess inter- intra-datasets variability, focusing on image acquisition experimental protocols, optimize analysis comparing hemodynamic response functions denoising methods. Approach: collected 17 datasets from 10 centers, applied standardized preprocessing, analyzed responses at...
Combining fMRI and fluorescence recordings has become an important tool for neuroimaging. However, hemodynamic changes lead to artifacts in recordings, since blood absorbs light. We investigated the artifact functional pharmacological MRI measurements present MRI-based correction method. In both stimulation lactate injection experiments, FRET occurred. These cannot be removed effectively using a standard (purely optical) An presented this work eliminates while expected signal persist.