A5046881768- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Associations and Epidemiology
- Botulinum Toxin and Related Neurological Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Transcranial Magnetic Stimulation Studies
- Genomic variations and chromosomal abnormalities
- Bioinformatics and Genomic Networks
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Genetic and phenotypic traits in livestock
- Genomics and Rare Diseases
- Plant Reproductive Biology
- Parkinson's Disease and Spinal Disorders
- Lysosomal Storage Disorders Research
- Chromosomal and Genetic Variations
- Plant Molecular Biology Research
- Liver Disease Diagnosis and Treatment
- Restless Legs Syndrome Research
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Reproductive biology and impacts on aquatic species
Capital Medical University
2016-2025
Shanghai University of Traditional Chinese Medicine
2022-2025
National Clinical Research Center for Digestive Diseases
2016-2025
China Medical University
2025
Beijing Tian Tan Hospital
2013-2024
Chung Shan Medical University
2024
Nanjing Hydraulic Research Institute
2022-2024
Wayne State University
2016-2023
Chinese Institute for Brain Research
2015-2023
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2022
Abstract Background Crohn’s disease (CD) poses a significant risk of postoperative recurrence (POR), complicating management, and data on the use Ustekinumab (UST) in CD patients China is limited. This study evaluated efficacy safety UST preventing POR. Methods multicenter, retrospective observational involved from four Chinese tertiary hospitals, all whom had at least two high-risk factors. Patients who failed anti-TNF-α treatments or Vedolizumab switched to as non-first-line therapy, while...
OBJECTIVE To estimate the incidence and identify risk factors for diagnosed type 2 diabetes (T2D) among young U.S. adults. RESEARCH DESIGN AND METHODS We analyzed 142,884 adults aged 18–79 years with self-reported from cross-sectional National Health Interview Survey in 2016–2022, representing noninstitutionalized civilian population. Incidence of T2D was calculated three age groups: young-adult onset (18–44 years), middle-age (45–64 older-adult (65–79 years); latter two groups were included...
Abstract Large genome‐wide association studies (GWAS) have been performed to detect common genetic variants involved in diseases, but most of the found this way account for only a small portion trait variance. Furthermore, candidate gene‐based resequencing suggests that many rare contribute variance diseases. Here we propose two designs, sibpair and unrelated‐case either or analysis. First show can classify together risk haplotypes using relatively sample with these then increased power test...
Locus coeruleus (LC) is severely affected in Parkinson's Disease (PD). However, alterations LC-related resting-state networks (RSNs) PD remain unclear. We used functional MRI to investigate the connectivity (FC) of RSNs and associations between changes clinical features idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with (PDRBD+) without RBD (PDRBD-). There was a similarly disrupted FC pattern iRBD PDRBD+ patients, whereas were less damaged PDRBD- than that PDRBD+. The...
Mild cognitive impairment (MCI) is a common symptom at the baseline of early Parkinson's disease (PD) diagnosis, but neural mechanism unclear. To address issue, present study employed resting-state functional magnetic resonance imaging data 19 drug-naïve PD patients with normal cognition (PD-NC), 10 MCI (PD-MCI) and 13 age- gender-matched healthy controls (HC) from progression markers initiative (PPMI) (http://www.ppmi-info.org/), examined abnormal spontaneous brain activities in PD-MCI. The...
Urinary dysfunction is an early manifestation of autonomic in Multiple System Atrophy (MSA) and often precedes orthostatic hypotension. This study investigated the diagnostic efficacy post-void residual (PVR) urine volume differentiating possible MSA from early-stage Parkinson's disease (PD) sought to identify a feasible combination nervous system indicators for clinical use. The distribution α-Synuclein (α-Syn) forms erythrocyte was preliminary explored. included 70 patients with MSA-P, 73...
Objective This study aimed to develop a simplified insulin medication literacy scale for patients with diabetes mellitus in China (Ch-InMLS), assess the level of literacy, and evaluate its psychometric properties. Methods We developed an initial based on framework knowledge–attitude–practice model (KAP), “skills” added. The items were from literature review insulin-related guidelines, semi-structured interviews, face validity. After two rounds expert consultation pilot survey, final version...
It is generally known that risk variants segregate together with a disease within families, but this information has not been used in the existing statistical methods for detecting rare variants. Here we introduce two weighted sum statistics can apply to either genome-wide association data or resequencing identifying variants: weights calculated based on sibpairs and odd ratios, respectively. We evaluated via extensive simulations under different models. compared proposed statistic (WSS) by...
Abstract Background Interactions among genomic loci (also known as epistasis) have been suggested one of the potential sources missing heritability in single locus analysis genome-wide association studies (GWAS). The computational burden searching for interactions is compounded by extremely low threshold identifying significant p-values due to multiple hypothesis testing corrections. Utilizing prior biological knowledge restrict set candidate SNP pairs be tested can alleviate this problem,...
The differentiation between essential tremor (ET) and Parkinson's disease (PD) can be difficult because of the symptom overlaps. Erythrocytes are major source peripheral α-synuclein (α-syn), which is most studied pathological molecular PD. We have reported that erythrocytic α-syn levels in PD patients significantly increased compared to those healthy controls (HCs). However, little known about species ET patients.This study includes 15 with ET, 64 PD, 49 age sex matched HCs. A...
Chronic levodopa (L-dopa) treatment in Parkinson's disease (PD) is often associated with the development of motor complications, but corresponding epidemiological data rare Chinese PD patients. The present survey was to investigate prevalence rate wearing-off (WO) and dyskinesia among patients China. From May 2012 October 2012, a 3-step registry for wearing off receiving therapy performed simultaneously at 28 movement disorders clinics There were 1,558 fulfilling inclusion criteria. Among...
Gene duplication is a primary means to generate genomic novelties, playing an essential role in speciation and adaptation. Particularly plants, high abundance of duplicate genes has been maintained for significantly long periods evolutionary time. To address the manner which young were derived primarily from small-scale gene preserved plant genomes determine underlying driving mechanisms, we generated transcriptomes produce expression profiles five tissues Arabidopsis thaliana closely...