A5102793330- Parkinson's Disease Mechanisms and Treatments
- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Advanced Algorithms and Applications
- Glioma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Nuclear Receptors and Signaling
- Photoreceptor and optogenetics research
- Neural Networks and Applications
- Face and Expression Recognition
- Restless Legs Syndrome Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Fault Detection and Control Systems
- Advanced Sensor and Control Systems
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Light effects on plants
- Circular RNAs in diseases
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Advanced Measurement and Detection Methods
- Radiomics and Machine Learning in Medical Imaging
- Drug Transport and Resistance Mechanisms
Capital Medical University
2016-2025
Beijing Geriatric Hospital
2010-2025
Ministry of Education of the People's Republic of China
2011-2025
National Clinical Research Center for Digestive Diseases
2018-2024
Duke University
2024
Jinan University
2016-2022
University of Jinan
2022
Northwest University of Politics and Law
2021
National Clinical Research
2020
McGill University
2020
This study explores the effect of risk factors on progression idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) to α-synucleinopathies in a Chinese cohort. Patients with iRBD were enrolled and assessed for environmental lifestyle using standardized structured questionnaires at baseline. All patients prospectively followed phenoconversion monitoring. The cumulative incidence was estimated survival analysis. Of 155 cohort, follow-up information available 141 patients. rate...
There is a growing number of clinical studies that revealed variety behavioral and physiological desynchronies in patients with Parkinson's disease (PD). However, these have not been defined at the molecular level.Using real-time RT-PCR assay, we analyzed expression profiles two principle clock genes, PER1 BMAL1, total leukocytes for 12 h during evening, overnight morning subjects PD age/sex-matched healthy controls.A difference pattern BMAL1 but was apparent dark span, where relative...
Abstract Accumulating evidence indicates an association between the circadian clock and aging process. However, it remains elusive whether deregulation of proteins underlies stem cell they are targetable for alleviation aging-associated syndromes. Here, we identified a transcription factor-independent role CLOCK, core component molecular machinery, in counteracting human mesenchymal (hMSC) decay. CLOCK expression was decreased during hMSC aging. In addition, deficiency accelerated...
Plasma amyloid-β (Aβ) may facilitate identification of individuals with brain amyloidosis. Gut microbial dysbiosis in Alzheimer's disease (AD) is increasingly being recognized. However, knowledge about alterations gut microbiota preclinical AD, as well whether the combination plasma Aβ and could identify remains largely unknown.This study recruited 34 Aβ-negative cognitively normal (CN-) participants, 32 Aβ-positive (CN+) 22 patients cognitive impairment (CI), including 11 mild (MCI) AD...
Abnormal activation of immune system is an important pathogenesis Parkinson's disease, but the relationship between peripheral inflammation, central microglia and dopaminergic degeneration remains unclear.To evaluate brain regional its with clinical severity, presynaptic function, inflammatory biomarkers related to adaptive immunity.In this case-control study, we recruited 23 healthy participants 24 early-stage disease. 18F-PBR06 PET/MR for activation, 18F-FP-DTBZ denervation, total account...
Abstract Circadian disruptions may result in sleep problems, oxidative stress and an altered inflammatory response. These symptoms contribute to PD pathogenesis, despite a lack of direct experimental evidence supporting this relationship. Clock genes are essential drive maintain circadian rhythm. To elucidate the possible role PD, we investigated 132 tag variants eight clock genes. We genotyped these tags within 1,394 Chinese cases 1,342 controls using Illumina GoldenGate chips. discovered...
Abstract Background Blood biomarkers that can be used for preclinical Alzheimer’s disease (AD) diagnosis would enable trial enrollment at a time when the is potentially reversible. Here, we investigated plasma neuronal-derived extracellular vesicle (nEV) cargo in patients along continuum, focusing on cognitively normal controls (NCs) with high brain β-amyloid (Aβ) loads (Aβ+). Methods The study was based Sino Longitudinal Study Cognitive Decline project. We enrolled 246 participants,...
The molecular clock machinery in mammals consists of a number genes (CGs) and their resultant proteins that form interlocking transcription‐translation feedback loops. These loops generate maintain the 24 h mRNA protein oscillations consequential biological physiological rhythms. To understand whether peripheral oscillators share similarly‐timed machinery, temporal expression patterns seven recognized key CGs (mPer1, mPer2, mCry1, mCry2, mRev‐erb alpha, mClock, mBmal1) were examined...
Abstract INTRODUCTION Subjective cognitive decline (SCD) in amyloid‐positive (Aβ+) individuals was proposed as a clinical indicator of Stage 2 the Alzheimer's disease (AD) continuum, but this requires further validation across cultures, measures, and recruitment strategies. METHODS Eight hundred twenty‐one participants from SILCODE DELCODE cohorts, including normal controls (NC) with SCD recruited community or memory clinics, underwent neuropsychological assessments over up to 6 years....
The burgeoning volume of electronic health records (EHRs) has enabled deep learning models to excel in predictive healthcare. However, for high-stakes applications such as diagnosis prediction, model interpretability remains paramount. Existing prediction with intrinsic often assign attention weights every past or hospital visit, providing explanations lacking flexibility and succinctness. In this paper, we introduce SHy, a self-explaining hypergraph neural network model, designed offer...
Abundant evidence has suggested that neuroinflammation participates in the pathogenesis of Parkinson's disease (PD). The emerging supported microglia may play key roles progressive neurodegeneration PD and might be a promising therapeutic target. Ganoderma lucidum (GL), traditional Chinese medicinal herb, been shown potential neuroprotective effects our clinical trials make us to speculate it possess potent anti-inflammatory immunomodulating properties. To test this hypothesis, we...
Alzheimer's disease (AD) is the most common neurodegenerative disorder with a continuous pathophysiological process starting from preclinical and mild cognitive impairment (MCI) phases to dementia phase. Early diagnosis prerequisite for early intervention of AD but meanwhile challenging. Amyloid-beta 1–42 (Aβ42) plays crucial part in pathology. Positron-emission tomography (PET) imaging Aβ42 brain measurement cerebrospinal fluid (CSF) have been adopted auxiliary AD, their widespread clinical...
Among cerebral venous thrombosis (CVT) patients, those with infarction have more severe clinical presentations and worse outcomes.Identifying biomarkers associated in CVT may help understand the pathogenesis provide potentially useful therapeutic markers.Fifty-two patients were prospectively recruited divided into three groups: acute/subacute (ASVI, n=30), without (ASOVI, n=13), chronic (n=9).Blood brain barrier (BBB) permeabilityrelated proteins, including claudin-5, occludin, matrix...
Background Alzheimer's disease (AD) is the most common form of dementia in older adults. There accumulating evidence that inflammatory processes play a critical role AD pathogenesis. In this study, we investigated whether factors plasma and astrocyte-derived exosomes (ADEs) from are differentially expressed early stages their potential pathological continuum. Method We included 39 normal controls (NCs), 43 participants with subjective cognitive decline (SCD), amnestic mild impairment...
Serine 129-phosphorylated alpha-synuclein (pS-α-syn) is a major form of α-syn relevant to the pathogenesis Parkinson's disease (PD), which has been recently detected in red blood cells (RBCs). However, alterations RBC-derived pS-α-syn (pS-α-syn-RBC) different subtypes and stages PD remains be investigated. In present study, by using enzyme-linked immunosorbent assay (ELISA) measure pS-α-syn-RBC, we demonstrated significantly higher levels pS-α-syn-RBC patients than healthy controls....