Slawek Altenstein
A5078895221- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
- Nutritional Studies and Diet
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Machine Learning in Healthcare
- Cerebrospinal fluid and hydrocephalus
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Music Perception
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Music Therapy and Health
- Consumer Attitudes and Food Labeling
- Neurobiology of Language and Bilingualism
- Neuroinflammation and Neurodegeneration Mechanisms
- Brain Tumor Detection and Classification
- Cognitive Functions and Memory
- Biochemical Analysis and Sensing Techniques
- Advanced MRI Techniques and Applications
- Single-cell and spatial transcriptomics
- Identity, Memory, and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
Humboldt-Universität zu Berlin
2023-2024
German Center for Neurodegenerative Diseases
2018-2024
Charité - Universitätsmedizin Berlin
2019-2024
Freie Universität Berlin
2023-2024
University of Bonn
2023
University Hospital Bonn
2021
The University of Texas Health Science Center at San Antonio
2021
To determine whether following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross-sectional data from the German DZNE-Longitudinal Cognitive Impairment Dementia Study. METHOD: The sample (n=512, mean age: 69.5±5.9 years) included 169 cognitively normal participants subjects at higher AD risk (53 with relatives AD, 209 subjective decline, 81 mild impairment). We defined MeDi adherence based on Food Frequency...
Subjective cognitive decline (SCD) has been proposed as a pre-MCI at-risk condition of Alzheimer’s disease (AD). Current research is focusing on refined assessment specific SCD features associated with increased risk for AD, in the SCD-plus criteria. We developed structured interview (SCD-I) these and tested their relationship AD biomarkers. analyzed data 205 cognitively normal participants DELCODE study (mean age = 68.9 years; 52% female) available CSF biomarkers (Aß-42, p-Tau181, Aß-42/Tau...
Abstract Introduction It is uncertain whether subjective cognitive decline (SCD) in individuals who seek medical help serves the identification of initial symptomatic stage 2 Alzheimer's disease (AD) continuum. Methods Cross‐sectional and longitudinal data from multicenter, memory clinic–based DELCODE study. Results The SCD group showed slightly worse cognition as well more subtle functional behavioral symptoms than control (CO). SCD–A+ cases (39.3% all SCD) greater hippocampal atrophy,...
<h3>Background and Objectives</h3> We assessed whether novelty-related fMRI activity in medial temporal lobe regions the precuneus follows an inverted U-shaped pattern across clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially individuals with a higher AD due to subjective cognitive decline (SCD) or mild impairment (MCI). further differences related diagnostic groups were accounted by CSF markers brain atrophy....
Abstract Background Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neurodegeneration measures. We investigated experimental inflammation in serum analyzed interrelations towards AD pathology features cohort with focus on at-risk stages AD. Methods Data 74 healthy controls (HC), 99 subjective cognitive decline (SCD),...
Abstract Memory clinic patients are a heterogeneous population representing various aetiologies of pathological ageing. It is not known whether divergent spatiotemporal progression patterns brain atrophy, as previously described in Alzheimer’s disease patients, prevalent and clinically meaningful this group older adults. To uncover distinct atrophy subtypes, we applied the Subtype Stage Inference (SuStaIn) algorithm to baseline structural MRI data from 813 participants enrolled DELCODE...
Background: Although convolutional neural networks (CNN) achieve high diagnostic accuracy for detecting Alzheimer's disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason this is a lack of model comprehensibility. Recently developed visualization methods deriving CNN relevance maps may help to fill gap. We investigated whether models with higher also rely more discriminative brain regions predefined by prior...
It remains unclear whether functional brain networks are consistently altered in individuals with subjective cognitive decline (SCD) of diverse ethnic and cultural backgrounds the network alterations associated an amyloid burden.Cross-sectional resting-state magnetic resonance imaging connectivity (FC) amyloid-positron emission tomography (PET) data from Chinese Sino Longitudinal Study on Cognitive Decline German DZNE Impairment Dementia cohorts were analyzed.Limbic FC, particularly...
Abstract Neuroinflammation is a hallmark of Alzheimer’s disease (AD) and both positive negative associations individual inflammation-related markers with brain structure cognitive function have been described. We aimed to identify inflammatory signatures CSF immune-related that relate changes cognition across the clinical spectrum ranging from normal aging AD. A panel 16 markers, Aβ42/40 p-tau181 were measured in at baseline DZNE DELCODE cohort ( n = 295); longitudinal observational study...
Soluble amyloid beta (Aβ) oligomers have been suggested as initiating Aβ related neuropathologic change in Alzheimer's disease (AD) but their quantitative distribution and chronological sequence within the AD continuum remain unclear.
To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia.
Abstract Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME prototypical novelty-related and memory-related functional MRI activation patterns in young adults have been proposed as imaging biomarkers of healthy neurocognitive ageing. Here, we tested utility these potential diagnostic prognostic markers Alzheimer’s disease (AD) risk states like mild cognitive impairment (MCI) subjective decline (SCD). To this end, analysed subsequent memory data...
Abstract INTRODUCTION Subjective cognitive decline (SCD) in amyloid‐positive (Aβ+) individuals was proposed as a clinical indicator of Stage 2 the Alzheimer's disease (AD) continuum, but this requires further validation across cultures, measures, and recruitment strategies. METHODS Eight hundred twenty‐one participants from SILCODE DELCODE cohorts, including normal controls (NC) with SCD recruited community or memory clinics, underwent neuropsychological assessments over up to 6 years....
Abstract INTRODUCTION Blood‐based biomarkers are a cost‐effective and minimally invasive method for diagnosing the early preclinical stages of amyloid positivity (AP). Our study aims to investigate our novel immunoprecipitation‐immunoassay (IP‐IA) as test predicting cognitive decline. METHODS We measured levels beta (Aβ)X‐40 AβX‐42 in immunoprecipitated eluates from DELCODE cohort. Receiver‐operating characteristic (ROC) curves, regression analyses, Cox proportional hazard models were...
We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age.We conducted a cross-sectional analysis observational, multicentric DZNE-Longitudinal Cognitive Impairment Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, 15 with mild impairment)....
Regular musical activity as a complex multimodal lifestyle is proposed to be protective against age-related cognitive decline and Alzheimer's disease. This cross-sectional study investigated the association interplay between instrument playing during life, multi-domain abilities brain morphology in older adults (OA) from DZNE-Longitudinal Cognitive Impairment Dementia Study (DELCODE) study. Participants reporting having played across three life periods (n = 70) were compared controls without...
White matter hyperintensities (WMH) in subjects across the Alzheimer's disease (AD) spectrum with minimal vascular pathology suggests that amyloid pathology-not just arterial hypertension-impacts WMH, which turn adversely influences cognition. Here we seek to determine effect of both hypertension and Aβ positivity on their impact cognition.We analysed data from a low profile normal cognition (NC), subjective cognitive decline (SCD), amnestic mild impairment (MCI) enrolled ongoing...
Impaired long-term memory is a defining feature of mild cognitive impairment (MCI). We tested whether this item specific, limited to some memoranda, whereas remain consistently memorable.
To determine the relevance of minor neuropsychological deficits (MNPD) in patients with subjective cognitive decline (SCD) regard to CSF levels Alzheimer disease (AD) biomarkers, decline, and clinical progression mild impairment (MCI).This study included SCD SCD-free, healthy control (HC) participants available baseline and/or longitudinal data from observational DZNE Longitudinal Cognitive Impairment Dementia study. We defined MNPD as a performance at least 0.5SD below mean on...
Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when anatomy space (PVS) is altered during AD progression. Therefore, this study investigates association between PVS volume and progression in cognitively unimpaired (CU) individuals, both with without subjective cognitive decline (SCD), those clinically diagnosed mild impairment (MCI) or AD.
Abstract Background Early identification of individuals at risk dementia is mandatory to implement prevention strategies and design clinical trials that target early disease stages. Subjective cognitive decline (SCD) neuropsychiatric symptoms (NPS) have been proposed as potential markers for manifestation Alzheimer’s (AD). We aimed investigate the frequency NPS in SCD, other at-risk groups, healthy controls (CO), AD patients, test association with biomarkers, a particular focus on...
Cognitive decline has been found to be associated with gray matter atrophy and disruption of functional neural networks in Alzheimer's disease (AD) structural imaging (fMRI) studies. Most previous studies have used single test scores cognitive performance among monocentric cohorts. However, domain composite could more reliable than due the reduction measurement error. Adopting a multicentric resting state fMRI (rs-fMRI) approach, we provide comprehensive description correlates key domains...
Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for investigation cBF changes in-vivo. In this study we assessed alterations functional connectivity (FC), mean diffusivity (MD), and volume across spectrum AD. We further effects amyloid pathology on these changes. Participants included healthy controls, subjects subjective (SCD), mild impairment (MCI), or AD dementia (ADD) from multicenter DELCODE...
Several lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been described for occupational cognitive requirements (OCR) in midlife, it is currently unknown whether they are conveyed by brain maintenance (BM), reserve (BR), or (CR) combination of them.We systematically derived hypotheses these resilience concepts and tested them the population-based AgeCoDe cohort memory clinic-based AD high-risk DELCODE...