A5055216581- Dementia and Cognitive Impairment Research
- Mindfulness and Compassion Interventions
- Intensive Care Unit Cognitive Disorders
- Alzheimer's disease research and treatments
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Health Literacy and Information Accessibility
- Stroke Rehabilitation and Recovery
- Sleep and related disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Neurological Disorders and Treatments
- Technology Use by Older Adults
- Retirement, Disability, and Employment
- Schizophrenia research and treatment
- Psychiatric care and mental health services
- Consumer Attitudes and Food Labeling
- Cerebrospinal fluid and hydrocephalus
- Cognitive Functions and Memory
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Healthcare cost, quality, practices
- Diet and metabolism studies
University Hospital Cologne
2017-2024
University of Cologne
2018-2024
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2023
German Center for Neurodegenerative Diseases
2020
University of Exeter
2018
University of Geneva
2018
Cyceron
2018
Inserm
2018
Université de Caen Normandie
2018
Centre National de la Recherche Scientifique
2018
Neurological symptoms, in particular cognitive deficits, are common post-COVID-19 syndrome (PCS). There is no approved therapy available, and the underlying disease mechanisms largely unknown. Besides others, autoimmune processes may play a key role.We here present data of prospective study conducted between September 2020 December 2021 performed at two German University hospitals with specialized Neurology outpatient clinics. Fifty patients self-reported deficits as main complaint PCS...
Abstract Background A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part the post-COVID-19 syndrome. This study aimed assess neuropsychological profile these patients. Methods Assessment at baseline (three months or more following COVID-19) a monocentric prospective cohort Multidomain tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, general health status administered. Results Of 58 screened, six...
To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia.
<b><i>Introduction:</i></b> Several recent research studies show high performance of blood biomarkers to identify Alzheimer’s disease also in the pre-dementia mild cognitive impairment (MCI) stage, but data from routine clinical care memory clinic setting are needed. <b><i>Methods:</i></b> We examined plasma samples 144 patients, including dementia Alzheimer type (DAT, <i>n</i> = 54), MCI (<i>n</i> 57), and subjective...
Abstract: Cognitive impairment is a prominent symptom of the post-COVID syndrome (PCS). However, correspondence between subjective cognitive complaints (SCC) and objective results inconsistent. Here, we investigated this discrepancy. This longitudinal study included N = 42 individuals who reported SCC as PCS after mild infection at inclusion. Data collection comprised questionnaires neuropsychological assessment baseline follow-up (FU). At FU – on average 15 months acute COVID-19 88 %...
Abstract Some people infected with SARS-CoV-2 report persisting symptoms following acute infection. If these persist for over three months, they are classified as post-COVID-19 syndrome (PCS). Although PCS is frequently reported, detailed longitudinal neuropsychological characterization remains scarce. We aimed to describe the trajectory of cognitive and neuropsychiatric symptoms. 42 individuals deficits after asymptomatic mild/moderate COVID-19 at study inclusion received assessment...
Abstract Introduction Subjectively experienced cognitive decline in older adults is an indicator of increased risk for dementia and also associated with levels anxiety symptoms. As itself emerging as a factor dementia, the primary question present study whether 8‐week mindfulness‐based intervention can significantly reduce symptoms patients subjective (SCD). The secondary questions pertain to such changes extend other domains psychological, social, biological functioning (including...
<b><i>Introduction:</i></b> Older adults experiencing subjective cognitive decline (SCD) have a heightened risk of developing dementia and frequently experience subclinical anxiety, which is itself associated with risk. <b><i>Objective:</i></b> To understand whether anxiety symptoms in SCD can be reduced through behavioral interventions. <b><i>Methods:</i></b> SCD-Well randomized controlled trial designed to determine an...
Abstract Background Older individuals with subjective cognitive decline (SCD) perceive that their cognition has declined but do not show objective impairment on neuropsychological tests. Individuals SCD are at elevated risk of and incident dementia. Non-pharmacological interventions (including mindfulness-based health self-management approaches) a potential strategy to maintain or improve in SCD, which may ultimately reduce dementia risk. Methods This study utilized data from the SCD-Well...
Cognitive impairment is the most frequent symptom reported in post-COVID-19 syndrome (PCS). Aetiology of cognitive PCS still to be determined. Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are increased acute COVID-19. Their role as biomarkers other neurological disorders under debate. We analysed serum levels NfL GFAP markers for neuronal astrocytic damage 53 patients presenting a Neurology outpatient clinic. Only individuals with self-reported complaints were...
Abstract Background Early identification of individuals at risk dementia is mandatory to implement prevention strategies and design clinical trials that target early disease stages. Subjective cognitive decline (SCD) neuropsychiatric symptoms (NPS) have been proposed as potential markers for manifestation Alzheimer’s (AD). We aimed investigate the frequency NPS in SCD, other at-risk groups, healthy controls (CO), AD patients, test association with biomarkers, a particular focus on...
Nonpharmacological interventions are a potential strategy to maintain or promote cognitive functioning in older adults.
Abstract Introduction Individuals with subjective cognitive decline (SCD) are at increased risk of Alzheimer's disease and could benefit from a prevention strategy targeting lifestyle factors. Making program available through the Internet gives widespread reach low cost, but suboptimal adherence is major threat to effectiveness. As first step in developing an online (OLP), we aimed identify factors that barriers and/or facilitators for use OLP individuals SCD three European countries....
Abstract INTRODUCTION Understanding the impact of biomarker‐based dementia risk estimation in people with mild cognitive impairment (MCI) and their care partners is critical for patient care. METHODS MCI patients study were counseled on Alzheimer's disease (AD) biomarker was disclosed. Data mood, quality life (QoL), satisfaction (SwL) obtained 1 week 3 months after disclosure. RESULTS Seventy‐five dyads enrolled, two‐thirds opted testing. None participants experienced clinically relevant...
Zusammenfassung: Gedächtnisambulanzen sind spezialisierte und multidisziplinäre Einrichtungen zur (Früh-)Erkennung demenzieller Erkrankungen, welche zwar unterschiedliche institutionelle Rahmenbedingungen inhaltliche Schwerpunkte aufweisen, die aber auch viele Gemeinsamkeiten haben in Bezug auf diagnostische Abläufe therapeutisches Handeln. Für neuropsychologische Diagnostik als Kernelement der Demenzdiagnostik liegen zahlreiche etablierte Testverfahren vor, einheitliche Standards für...
Background: The Lifetime of Experiences Questionnaire (LEQ) assesses complex mental activity across the life-course and has been associated with brain cognitive health. different education systems occupation classifications countries represent a challenge for international comparisons. objectives this study were four-fold: to adapt harmonise LEQ four European countries, assess its validity explore association cognition begin investigate between-country differences in activities. Method: was...
Background: Online programs targeting lifestyle have the potential to benefit brain health. We aimed develop such a program for individuals with subjective cognitive decline (SCD). These were reported be at increased risk dementia, and report both an intrinsic need health information motivation participate in prevention strategies. Co-creation user-evaluation benefits adherence acceptance of online programs. Previously, we developed prototype co-creation users . Objectives: now evaluate...
Social cognition (SC) is a core criterion for neurocognitive disorders. However, findings in patients with amnestic mild cognitive impairment (aMCI) and dementia of the Alzheimer type (DAT) are inconsistent.We report assessments emotion recognition (ER), affective theory mind (ToM) young (YC) older controls (OC) compared to aMCI DAT.28 aMCI, 30 DAT, YC, 29 OC received tests SC comprehensive neuropsychological assessment. Analysis covariance was used determine group differences. Multiple...
The NIA-AA Research Framework on Alzheimer's disease (AD) proposes a transitional stage (stage 2) characterized by subtle cognitive decline, subjective decline (SCD) and mild neurobehavioral symptoms (NPS).
Abstract Background Value‐based healthcare (VBHC) is a novel concept derived from economic research which recently implemented in various medical departments and facilities. Additionally to an improvement of patient care, it postulates reduction expenses by providing patients with what they really need. Value this context defined as outcomes achieved for relative the required costs. In VBHC collecting patient‐reported outcome measures (PROM) experience (PREM) essential clarify patients’...
Abstract Background Subjective cognitive decline (SCD) denotes self‐reported concerns in the absence of objective impairment. Individuals with SCD convert to dementia at twice annual rate healthy controls, relatively poorer cognition conferring additional risk. Non‐pharmacological interventions are currently undergoing intensive evaluation for promoting function SCD. Method This study utilized data from SCD‐Well randomized controlled trial. One hundred forty‐seven older adults SCD, recruited...