Laura Richert
A5019198664- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Viral Infections and Outbreaks Research
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- Hepatitis B Virus Studies
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- HIV/AIDS Research and Interventions
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Viral Infections and Vectors
- Statistical Methods in Clinical Trials
- Reproductive System and Pregnancy
- Influenza Virus Research Studies
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis C virus research
- Advanced Causal Inference Techniques
- Molecular Biology Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Radiomics and Machine Learning in Medical Imaging
- Computational Drug Discovery Methods
Université de Bordeaux
2015-2024
Institut national de recherche en informatique et en automatique
2014-2024
Centre Hospitalier Universitaire de Bordeaux
2015-2024
Bordeaux Population Health
2015-2024
Inserm
2015-2024
Institut Bergonié
2022-2024
Institut de Recherche Vaccinale
2014-2024
Clinical Investigation Center Plurithematic Tours
2021-2024
Université Paris-Est Créteil
2022-2024
French Clinical Research Infrastructure Network
2017-2022
Large unselected studies on representative samples of HIV-infected patients with a whole battery neuropsychological tests and cerebral MRI scan are required to assess the frequency neurocognitive impairment (NCI), determinants mild disorders (MNDs), or HIV-associated dementia (HAD) relationship between NCI findings.Investigation 400 consecutively enrolled HIV-1-infected adults from ANRS CO3 Aquitaine Cohort, using standardized chosen achieve consistency Frascati's criteria. Half had allowing...
Efforts aimed at restoring robust immune responses limiting human immunodeficiency virus (HIV)-1 replication therapeutically are warranted. We report that vaccination with dendritic cells generated ex vivo and loaded HIV lipopeptides in patients (n = 19) on antiretroviral therapy was well tolerated immunogenic. Vaccination increased: (i) the breadth of response from 1 (1-3) to 4 (2-5) peptide-pool responses/patient (p 0.009); (ii) frequency functional T (producing least two cytokines among...
Predicting vaccine efficacy remains a challenge. We used systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes cytokine levels, cell subsets, gene expression. Integrative statistical analyses with cross-validation identified signature 5 markers correlating titers on day 28 beyond. Among those, IP-10 3 MFI CXCR6 NK cells 1 independent...
Immune responses differ between women and men, type I interferon (IFN) following Toll-like receptor 7 (TLR7) stimulation are higher in women. The precise mechanisms driving these sex differences immunity unknown. To investigate possible genetic factors, we quantify escape from X chromosome inactivation (XCI) for TLR7 four other genes (RPS6KA3, CYBB, BTK, IL13RA1) at the single plasmacytoid dendritic cell (pDC) level. We observe XCI all investigated genes, leading to biallelic expression...
Questions remain concerning the rapidity of immune responses and durability safety vaccines used to prevent Zaire Ebola virus disease.
Reoccurring Ebola outbreaks in West and Central Africa have led to serious illness death thousands of adults children. The objective this study was assess safety, tolerability, immunogenicity the heterologous 2-dose Ad26.ZEBOV, MVA-BN-Filo vaccination regimen adolescents children Africa.In multicentre, randomised, observer-blind, placebo-controlled Phase II study, 131 (12 17 years old) 132 (4 11 were enrolled from Eastern Western randomised 5:1 receive vaccines or placebo. Vaccine groups...
Destruction of the architectural and subsequently functional integrity lung following pulmonary viral infections is attributable to both extent pathogen replication host-generated inflammation associated with recruitment immune responses. The presence antigenically disparate viruses emergence novel assures recurrence damage infection resolution each primary infection. Thus, there a need develop safe broad spectrum immunoprophylactic strategies capable enhancing protective responses in but...
Metabolism is a critical basis for immune cell functionality. It was recently shown that NK subsets from peripheral blood modulate their expression of nutrient receptors following cytokine stimulation, demonstrating cells can adjust to changes in metabolic requirements. As availability and tissues significantly differ, we examined isolated paired blood-liver blood-spleen samples compared the transporters Glut1, CD98 CD71. CD56bright tissue-resident (CXCR6+) derived livers spleens expressed...
We investigated safety, tolerability, and immunogenicity of the heterologous 2-dose Ebola vaccination regimen in healthy HIV-infected adults with different intervals between vaccinations.
To provide up-to-date assessments of locomotor function in HIV-infected patients and to identify potential determinants impaired function.Cross-sectional study 324 HIV-1-infected adults from the French Agency for AIDS Hepatitis Research (ANRS) CO3 Aquitaine Cohort using standardized tests.Patients underwent testing assessing balance, walking ability, functional capacity lower limb muscle performance. Poor test performance was defined by cut-offs based on age-specific data general population....
To assess changes in locomotor function HIV-infected patients and to evaluate the determinants of variations lower limb muscle performance.Longitudinal study within ANRS CO3 Aquitaine Cohort.Standardized tests, including global functional capacity [6-min walk distance (6MWD)] performance tests [five times sit-to-stand (5STS) test], were performed adults at baseline 2-year follow-up. Evolution performances 5STS time studied linear mixed-effects models.At (354 patients, 90% on antiretroviral...
To assess the efficacy of inhaled ciclesonide in reducing risk adverse outcomes COVID-19 outpatients at developing severe illness.COVERAGE is an open-label, randomized controlled trial. Outpatients with documented COVID-19, factors for aggravation, symptoms ≤7 days, and absence criteria hospitalization are randomly allocated to either a control arm or one several experimental arms, including ciclesonide. The primary endpoint worsening (hospitalization, oxygen therapy home, death) by Day 14....
Recent Ebola outbreaks underscore the importance of continuous prevention and disease control efforts. Authorized vaccines include Merck's Ervebo (rVSV-ZEBOV) Johnson & Johnson's two-dose combination (Ad26.ZEBOV/MVA-BN-Filo). Here, in a five-year follow-up PREVAC randomized trial (NCT02876328), we report results immunology ancillary study trial. The primary endpoint is to evaluate long-term memory T-cell responses induced by three vaccine regimens: Ad26–MVA, rVSV, rVSV–booster....
The crosstalk between NK cells and their surrounding environment is enabled through activating inhibitory receptors, which tightly control cell activity. co-inhibitory receptor TIGIT decreases cytotoxicity involved in exhaustion, but has also been associated with liver regeneration, highlighting that the contribution of human intrahepatic CD56 bright regulating tissue homeostasis remains incompletely understood. A targeted single-cell mRNA analysis revealed distinct transcriptional...
Background We examined the hypothesis that high FGF-23 levels early after transplantation contribute to onset of hypophosphatemia, independently parathyroid hormone (PTH) and other factors regulating phosphate metabolism. Methods measured serum (sPi), renal tubular reabsorption Pi (TmPi/GFR), estimated GFR (eGFR), intact PTH (iPTH), calcitriol, (int) C-terminal (Cter) FGF-23, dietary intake cumulative doses glucocorticoids in 69 patients 12 days (95% confidence interval, 10–13)...