A5008312486- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Sex work and related issues
- HIV-related health complications and treatments
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Viral Infections and Outbreaks Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Fungal Infections and Studies
- Global Security and Public Health
- Nail Diseases and Treatments
- Viral-associated cancers and disorders
- COVID-19 Pandemic Impacts
- Disaster Response and Management
- Antifungal resistance and susceptibility
- Pharmacovigilance and Adverse Drug Reactions
- Mosquito-borne diseases and control
- Migration, Identity, and Health
- Polyomavirus and related diseases
- Malaria Research and Control
University Hospital Medical Center at Treichville
2011-2023
Université Félix Houphouët-Boigny
2014-2023
Programme PAC-CI
2013-2023
University Teaching Hospital
2014-2023
Bordeaux Population Health
2018-2021
Université de Bordeaux
2018
Université Nangui Abrogoua
2015-2018
Centre d'Immunologie et des Maladies Infectieuses
2011
The novel severe acute respiratory syndrome-coronavirus-2 pandemic has spread to Africa, where nearly all countries have reported laboratory-confirmed cases of coronavirus disease (COVID-19). Although there are ongoing clinical trials repurposed and investigational antiviral immune-based therapies, as yet no scientifically proven, clinically effective pharmacological treatments for COVID-19. Among the drugs, commonly used antimalarials chloroquine (CQ) hydroxychloroquine (HCQ) become focus...
Reoccurring Ebola outbreaks in West and Central Africa have led to serious illness death thousands of adults children. The objective this study was assess safety, tolerability, immunogenicity the heterologous 2-dose Ad26.ZEBOV, MVA-BN-Filo vaccination regimen adolescents children Africa.In multicentre, randomised, observer-blind, placebo-controlled Phase II study, 131 (12 17 years old) 132 (4 11 were enrolled from Eastern Western randomised 5:1 receive vaccines or placebo. Vaccine groups...
We investigated safety, tolerability, and immunogenicity of the heterologous 2-dose Ebola vaccination regimen in healthy HIV-infected adults with different intervals between vaccinations.
Cancer is a growing co-morbidity among HIV-infected patients worldwide. With the scale-up of antiretroviral therapy (ART) in developing countries, cancer will contribute more and to HIV/AIDS disease burden. Our objective was estimate association between HIV infection selected types cancers hospitalized for diagnosis or treatment West Africa.A case-referent study conducted referral hospitals Côte d'Ivoire Benin. Each participating clinical ward enrolled all adult seeking care confirmed...
Background People living with HIV-2 are mainly found in West Africa and their identification treatment have been impaired by diagnostic challenges availability of effective antiretroviral (ART). With the roll out first line dolutegravir (DTG)-based regimen, situation may improved, emphasizing need for data on long-term outcomes advanced HIV disease among ART-experienced people HIV-2. Method A prospective cohort was initiated 2012 Côte d’Ivoire Burkina Faso. All adult patients from an...
ABSTRACT Aim To investigate the association between alcohol use and adherence to highly active antiretroviral treatment (HAART) among human immunodeficiency virus (HIV)‐infected patients in subSaharan Africa. Design setting Cross‐sectional survey conducted eight adult HIV centres from Benin, Côte d'Ivoire Mali. Participants measurements During a 4‐week period, health workers administered Alcohol Use Disorders Identification Test HAART‐treated assessed using AIDS Clinical Trials Group...
Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment poorly effective since TBM mortality reaches 40% HIV-negative patients up to 70% HIV-co-infected patients. To reduce TBM-induced morbidity mortality, INTENSE-TBM trial evaluates two interventions both HIV-infected uninfected patients: an intensification using oral high-dose rifampicin (35 mg/kg daily) linezolid (1200 mg daily then 600 during...
Objective To describe changes in plasma viral load, CD4+ cell counts, and drug resistance profiles of HIV-2-infected patients receiving antiretroviral (ARV) therapy Abidjan, Côte d'Ivoire. Methods Consecutive blood samples were collected from 18 ARV- naive who had received ARV the UNAIDS access initiative (UNAIDS–DAI) Abidjan between August 1998 July 2000. Changes HIV-2 genotypic phenotypic testing determined. Results At baseline, 11 (61%) initiated highly active (HAART) seven (39%) dual...
To describe sexual and reproductive health (SRH) needs of female sex workers (FSWs) to inform the future implementation pre-exposure prophylaxis (PrEP) for HIV prevention in this population. The ANRS 12361 PrEP-CI cross-sectional mixed-methods study was designed implemented with two community-based organisations Côte d'Ivoire. A convenience sample 1000 FSWs aged ≥18, not known as HIV-positive, completed a standardised questionnaire assessing sociodemographic characteristics, practices, use...
Objective: To compare the lymphocyte T CD4+ (CD4) response to combinations of antiretroviral therapy (ART) in HIV-1, HIV-2 and dually positive patients West Africa. Design setting: Collaboration 12 prospective cohorts HIV-infected adults followed Senegal (2), Gambia (1), Mali Benin (1) Côte d'Ivoire (6). Subjects: Nine thousand, four hundred eighty-two infected by HIV-1 only, 270 only 321 positive, who initiated an ART. Outcome measures: CD4 change over a 12-month period. Results: Observed...
In resource‐constrained countries where the prevalence of hepatitis C virus (HCV) disease is usually high, it important to know which population should be treated first in order increase treatment effectiveness. The aim was estimate effectiveness different HCV eligibility scenarios three countries. Using a Markov model, we estimated number life‐years saved (LYS) with according fibrosis stage (F1‐F4 or F3‐4), compared base case (F2‐F4), at constant rate, patients between 18 and 60 years age,...
Background Plasma HIV-1 RNA monitoring is one of the standard tests for management infection. While can be quantified using several commercial tests, no test has been commercialized HIV-2 quantification. We studied relationship between plasma viral load (VL) and CD4 count in West African patients who were either receiving antiretroviral therapy (ART) or treatment-naïve. Method A cross sectional survey was conducted among HIV-2-infected individuals followed three countries Africa from March...
Abstract Background The novel coronavirus (2019-nCoV) epidemic has spread to 23 countries from China. Local cycles of transmission already occurred in 7 following case importation. No African country reported cases yet. management and control 2019-nCoV introductions heavily relies on country’s health capacity. Here we evaluate the preparedness vulnerability against their risk importation 2019-nCoV. Methods We used data air travel volumes departing airports infected provinces China directed...
The World Health Organization (WHO) recommends using insecticide-treated mosquito nets (ITNs) and intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) to prevent malaria in sub-Saharan Africa. Data on IPT-SP coverage factors associated placental parasitaemia low birth weight (LBW) are scarce Côte d'Ivoire.A multicentre, cross-sectional survey was conducted d'Ivoire from March September 2008 at six urban semi-urban antenatal clinics. Standardized forms were used collect...
Worldwide, female sex workers (FSW) represent a vulnerable population for oral diseases due to many risk factors including HIV infection and drug abuse. In sub-Saharan Africa, little is known about the burden of their determinants in populations. The aim study was estimate prevalence associated among FSW. A cross sectional conducted FSW who attended dedicated non-profit clinic Abidjan, Côte d'Ivoire from June August 2013. Data presence dental caries, periodontitis oral-mucosal lesions were...
In a cohort of HIV-infected patients sub-Saharan origin we describe the incidence metabolic syndrome, insulin resistance, and lipodystrophy after 3 years combined antiretroviral therapy, model 10-year risk cardiovascular diseases, while taking into account environmental factors. This is multinational, prospective study conducted in HIV outpatient clinics from four tertiary care centers set France Côte d'Ivoire. The participants were HIV-infected, treatment-naive eligible to start treatment...
As antiretroviral therapy continues to scale-up in developing countries, there is concern that high levels of HIV drug resistance drugs will occur. Here we describe rates emergence HIV-1 and factors associated with their occurrence among adults who received (ART) for >1 year through the Côte d'Ivoire national access program from 1998 2003. To detect genotypic resistance, sequenced all 1- 2-year specimens detectable RNA viral load. assess emerging used log normal regression interval...
ABSTRACT Background Although antiretroviral treatment (ART)–related adverse drug reactions (ADR) are documented in industrialised countries, there is no pre‐existing surveillance system dedicated to ADR monitoring most African countries. We assessed knowledge towards pharmacovigilance among ART prescribers and available capacity of HIV clinics conduct Abidjan, Côte d'Ivoire. Methods A questionnaire was administered assess their the occurrence ADRs. retrospective survey also conducted based...
Background: Reporting mortality and lost to follow-up (LTFU) by age is essential as older HIV-positive patients might be at risk of long-term effects living with HIV and/or taking antiretroviral therapy (ART). As not linear impact outcomes in the oldest more severely, people (PLHIV) aged 50–59 years PLHIV >60 were considered separately. Setting: Seventeen adult HIV/AIDS clinics spread over nine countries West Africa. Methods: Data collected within International Epidemiological Databases...