A5023535040- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- HIV Research and Treatment
- Immune cells in cancer
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Organ and Tissue Transplantation Research
- Full-Duplex Wireless Communications
Leibniz Institute of Virology (LIV)
2018-2023
Leibniz Association
2022
The crosstalk between NK cells and their surrounding environment is enabled through activating inhibitory receptors, which tightly control cell activity. co-inhibitory receptor TIGIT decreases cytotoxicity involved in exhaustion, but has also been associated with liver regeneration, highlighting that the contribution of human intrahepatic CD56 bright regulating tissue homeostasis remains incompletely understood. A targeted single-cell mRNA analysis revealed distinct transcriptional...
NK cells utilize a large array of receptors to screen their surroundings for aberrant or virus-infected cells. Given the vast diversity expressed on we seek identify involved in recognition HIV-1-infected By combining an unbiased large-scale screening approach with functional assay, TRAIL be associated cell degranulation against target Further investigating underlying mechanisms, demonstrate that is able elicit multiple effector functions human independent receptor-mediated induction...
NK cells play a pivotal role in viral immunity, utilizing large array of activating and inhibitory receptors to identify eliminate virus-infected cells. Killer-cell immunoglobulin-like (KIRs) represent highly polymorphic receptor family, regulating cell activity determining the ability recognize target Human leukocyte antigen (HLA) class I molecules serve as primary ligand for KIRs. Herein, HLA-C stands out being dominant majority Accumulating evidence indicated that interactions between its...
Antiviral NK cell activity is regulated through the interaction of activating and inhibitory receptors with their ligands on infected cells. HLA class I molecules serve as for most killer immunoglobulin-like (KIRs), but no receptor KIR2DL5 have been identified to date. Using a receptor/ligand screening approach, we observed strong binding or II molecules, confirmed that binds poliovirus (PVR, CD155). Functional studies using primary human cells revealed significantly decreased degranulation...