A5021368038- Genomics and Phylogenetic Studies
- Ginkgo biloba and Cashew Applications
- Plant Ecology and Taxonomy Studies
- Neurological Disease Mechanisms and Treatments
- Genetic diversity and population structure
- Chromosomal and Genetic Variations
- Species Distribution and Climate Change
- Plant Disease Resistance and Genetics
- Tree-ring climate responses
- DNA and Biological Computing
- Nuts composition and effects
- Plant biochemistry and biosynthesis
- Bacterial Genetics and Biotechnology
- Immune Cell Function and Interaction
- Mathematics and Applications
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- DNA and Nucleic Acid Chemistry
- Botany and Plant Ecology Studies
MUC Research (Germany)
2022-2025
Heidelberg University
2013-2024
European Bioinformatics Institute
1995
The Brassicaceae include several major crop plants and numerous important model species in comparative evolutionary research such as Arabidopsis, Brassica, Boechera, Thellungiella, Arabis species. As any hypothesis needs to be placed a temporal context, reliably dated splits within the evolution of are essential. We present comprehensive time-calibrated framework with divergence time estimates based on whole-chloroplast sequence data for 29 Diversification crown group started at...
Abstract Angiosperms have become the dominant terrestrial plant group by diversifying for ~145 million years into a broad range of environments. During course evolution, numerous morphological innovations arose, often preceded whole genome duplications (WGD). The mustard family (Brassicaceae), successful angiosperm clade with ~4000 species, has been many evolutionary lineages more than 30 years. Here we develop species inventory, analyze variation, and present maternal, plastome-based...
<title>Abstract</title> <italic>KIR3DS1</italic> is an activating natural killer (NK) cell receptor gene– present in 10-40% of humans– and associated with extended AIDS-free survival. Although its ligand HLA-F has been identified, the underlying protective mechanism HIV-1 not yet understood. We sought to uncover role KIR3DS1/HLA-F axis through investigating surface transcriptional changes during acute chronic infection. HLA-F<sup>+</sup> CD4 T cells were detected people living HIV (PLHIV)...
At the end of Pliocene and beginning Pleistocene glaciation deglaciation cycles Ginkgo biloba went extinct all over world, only few populations remained in China relict areas serving as sanctuary for Tertiary trees. Yet status these regions refuge with naturally existing has been proven not earlier than one decade ago. Herein we elaborated hypothesis that during cooling periods G. expanded its distribution range repeatedly. Whole plastid genomes were sequenced, assembled annotated, sequence...
NK cells play a pivotal role in viral immunity, utilizing large array of activating and inhibitory receptors to identify eliminate virus-infected cells. Killer-cell immunoglobulin-like (KIRs) represent highly polymorphic receptor family, regulating cell activity determining the ability recognize target Human leukocyte antigen (HLA) class I molecules serve as primary ligand for KIRs. Herein, HLA-C stands out being dominant majority Accumulating evidence indicated that interactions between its...
With accelerating global warming, understanding the evolutionary dynamics of plant adaptation to environmental change is increasingly urgent. Here, we reveal enigmatic history genus Cochlearia (Brassicaceae), a Pleistocene relic that originated from drought-adapted Mediterranean sister during Miocene. rapidly diversified and adapted circum-Arctic regions other cold-characterized habitat types Pleistocene. This sudden in ecological preferences was accompanied by highly complex, reticulate...
Abstract Transforming genomic and cellular landscapes in a single generation, whole genome duplication (WGD) brings fundamental challenges, but is also associated with diversification. How WGD tolerated, what processes commonly evolve to stabilize the resulting polyploid? Here we study this Cochlearia spp., which have experienced multiple WGDs last 300,000 years. We first generate chromosome-scale sequence 113 individuals from 33 diploid, tetraploid, hexaploid, outgroup populations. detect...
The rapidly falling costs and the increasing availability of large DNA sequence data sets facilitate fast affordable mining molecular markers for comprehensive evolutionary studies. Brassicaceae (mustards) are an important species-rich family in plant kingdom with taxa distributed worldwide a complex history. We performed SSRs (single short repeats) using de novo assembled transcriptomes from 19 species across order to study SSR evolution provide genetic studies within family. Moreover, we...
Abstract Convergent evolution is observed broadly across the web of life, but degree evolutionary constraint during adaptation core intracellular processes not known. High has been assumed for conserved processes, such as cell division and DNA repair, reports nimble shifts in these have confounded this expectation. Whole genome duplication (WGD) necessitates concerted adjustment a wide range fundamental functions nevertheless repeatedly survived all kingdoms. Given repeated to WGD despite...
Journal Article Mutational analysis of DNase I-DNA interactions: design, expression and characterization a I loop insertion mutant with altered sequence selectivity Get access Eva Wolf, Wolf Search for other works by this author on: Oxford Academic PubMed Google Scholar Ivan Brukner, Brukner 1International Centre Genetic Engineering BiotechnologyPadriciano 99, 34012 Trieste, Italy Dietrich Suck 2 2To whom correspondence should be addressed Protein Engineering, Design Selection, Volume 8,...
Abstract With accelerating global warming, understanding the evolutionary dynamics of plant adaptation to environmental change is increasingly urgent. Here we reveal enigmatic history genus Cochlearia (Brassicaceae), a Pleistocene relic that originated from drought-adapted Mediterranean sister during Miocene. rapidly diversified and adapted circum-Arctic regions other cold-characterized habitat types Pleistocene. This rapid in ecological preferences was accompanied by highly complex,...