A5001082370- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- Estrogen and related hormone effects
- Genomics, phytochemicals, and oxidative stress
- Synthesis and Biological Evaluation
- Respiratory viral infections research
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Ferrocene Chemistry and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Malaria Research and Control
- Hepatitis C virus research
- Cystic Fibrosis Research Advances
- T-cell and B-cell Immunology
- Electron Spin Resonance Studies
- Mosquito-borne diseases and control
- Hepatitis Viruses Studies and Epidemiology
- Platelet Disorders and Treatments
- Pleural and Pulmonary Diseases
- Congenital Ear and Nasal Anomalies
- Complement system in diseases
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Nitrogen and Sulfur Effects on Brassica
- Global Security and Public Health
Institut Cochin
2018-2023
Université Paris Cité
2014-2023
Inserm
2016-2023
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2017-2023
Assistance Publique – Hôpitaux de Paris
2014-2023
Hôpital Cochin
2014-2021
Délégation Paris 5
2019-2020
Hôpital Broca
2017-2020
Sorbonne Paris Cité
2017
Sorbonne Université
2017
The transcription factor NRF2 (NFE2L2), regulates important antioxidant and cytoprotective genes. It enhances cancer cell proliferation promotes chemoresistance in several cancers. Dimethyl fumarate (DMF) is known to promote activity noncancer models. We combined vitro vivo methods examine the effect of DMF on death activation pathway. demonstrated that at lower concentrations (<25 μmol/L), has a role through At higher concentrations, however (>25 caused oxidative stress subsequently...
Marginal zone (MZ) B cells are one of the main actors T-independent (TI) responses in mice. To identify cell subset(s) involved such humans, we vaccinated healthy individuals with Pneumovax, a model TI vaccine. By high-throughput repertoire sequencing plasma (PCs) isolated 7 days after vaccination and different subpopulations before vaccination, show that PC response mobilizes large clones systematically, including an immunoglobulin M component, whose diversification amplification predated...
Background: An overall response assay (OVA, based on a 23-valent pneumococcal polysaccharide vaccine (PPV23)) is widely used to screen for antipneumococcal antibodies. Given the heterogeneity of from one another, World Health Organization-standardized serotype-specific enzyme-linked immunosorbent (SSA) considered be only reliable method testing anti-polysaccharide antibody responses in individuals with suspected primary immunodeficiencies (PIDs). Objective: To evaluate OVA relative reference...
Patients with rheumatoid arthritis (RA) are at an increased risk of Pneumococcal infections. Immunogenicity and persistence a prime-boost revaccination strategy using 13-valent/23-valent anti-pneumococcal vaccines was evaluated in patients RA treated by Methotrexate (MTX) anti-TNF.Twenty-four received one dose PCV13 (Prevenar13®; Pfizer) followed two months later PPV23 (Pneumovax®, Merck). Concentrations IgG specific for 7 serotypes common to both 3 uncommon serotypes, included only the were...
We report on 11 cases of specific polysaccharide antibody deficiency (SPAD) revealed in adulthood by severe infections with encapsulated bacteria. Given that immunoglobulin replacement therapy can effectively prevent the recurrence bacterial this context, SPAD should be considered once other deficiencies have been ruled out.
Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder that frequently progress to (MM), a disease at high risk of pneumococcal infections. Moreover, if the polysaccharide vaccine poorly immunogenic in MM, 13-valent conjugated has never been tested disorders. We evaluated its immunogenicity for 7 serotypes 20 patients ≥ 50 years age with smoldering pre and post routine-vaccination PCV13.Concentrations IgG specific were measured baseline, 1, 6, 12 months after...
Abstract Background International guidelines recommend vaccinating allogeneic hematopoietic cell transplant (HCT) recipients at 3 months after transplant, giving doses of pneumococcal conjugate vaccine (PCV) followed by either a dose 23-valent polysaccharide (PSV23) or fourth PCV in the case graft-versus-host disease (GvHD). However, long-term immunity this regimen is unknown, and there no recommendation from 24 regarding boosts. Our objective was to assess antipneumococcal antibody titers...
Abstract Background Primary immunodeficiencies (PIDs) in adults are mainly revealed by recurrent and/or severe bacterial infections. The objective of this study was to evaluate a systematic research strategy PIDs with unexplained infections, special focus on specific polysaccharide antibody deficiency (SPAD). Methods In prospective multicenter study, inclusion criteria were benign upper and lower respiratory tract infections (RTIs) for at least two years (group 1), one or RTI requiring...
Background Patients with primary humoral immunodeficiency are more prone to invasive as well recurrent pneumococcal infections. Therefore, anti-pneumococcal vaccination including the 13-valent conjugate vaccine is recommended. Nevertheless, date, no data available on immunogenicity of this in population. Objective To assess and persistence protection up one year after a patients immunodeficiency. Methods Twenty-nine common variable or IgG subclass deficiency were vaccinated. Immune response...
Patients living with HIV (PLHIV) are prone to invasive pneumococcal disease. The 13-valent conjugated vaccine (PCV13) is currently recommended for all PLHIV, followed in most guidelines by a 23-valent polysaccharide vaccine. Data scarce concerning the immunological efficacy of PCV13 among PLHIV.To assess response at one month, and protection 1-, 6-, 12 months PLHIV CD4 cell count above 200 cells/µl after single dose PCV13, as measured both ELISA opsonophagocytic assay (OPA).PLHIV >200 were...
The transcription factor NRF2 (NFE2L2), regulates important antioxidant and cytoprotective genes. It enhances cancer cell proliferation promotes chemoresistance in several cancers. Dimethyl fumarate (DMF) is known to promote activity non-cancer models. We combined vitro vivo methods examine the effect of DMF on death activation pathway. demonstrated that at lower concentrations ( 25 M), caused oxidative stress subsequently cytotoxicity lines. High concentration decreases nuclear...
<p>Immunoblots showing the effect of DMF on NRF2 along with its associated proteins in various cancer cells.</p>
<p>Modulation of DMF-induced cell death by DJ1 levels in OVCAR3 cells.</p>
<p>Supplementary figure showing that high concentrations of DMF display cytotoxicity in several cancer cell lines</p>