A5050755416- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Fungal Infections and Studies
- T-cell and Retrovirus Studies
- Hematopoietic Stem Cell Transplantation
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Toxin Mechanisms and Immunotoxins
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Nail Diseases and Treatments
- Ubiquitin and proteasome pathways
- Eosinophilic Disorders and Syndromes
- Viral-associated cancers and disorders
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
Inserm
2016-2025
Université Paris Cité
2016-2025
Hôpital Saint-Louis
2016-2025
Assistance Publique – Hôpitaux de Paris
2014-2025
Institut de recherche Saint-Louis
2019-2024
Saint Louis University Hospital
2024
Centre Hospitalier Universitaire d'Angers
2023
Délégation Paris 7
2008-2021
Institut Universitaire de France
2008-2021
Sorbonne Paris Cité
2012-2021
A dangerous drug reaction may be caused by a severe immune response to reactivated resident herpes viruses.
Epidemiological and genome-wide association studies of severe psychiatric disorders such as schizophrenia (SZ) bipolar disorder (BD), suggest complex interactions between multiple genetic elements environmental factors. The involvement Human Endogenous Retroviruses type 'W' family (HERV-W) has consistently been associated with SZ. HERV-W envelope gene (env) is activated by factors encodes a protein displaying inflammation neurotoxicity. present study addressed the molecular characteristics...
Despite persistence of leukemic stem cells, patients with chronic myeloid leukemia who achieve and maintain deep molecular responses may successfully stop the tyrosine kinase inhibitor imatinib. However, questions remain unanswered regarding biological basis relapse after imatinib cessation. In IMMUNOSTIM, we monitored 51 from French Stop IMatinib trial for peripheral blood T cells natural killer cells. Molecular relapse-free survival at 24 months was 45.1% (95% CI: 31.44%–58.75%). At time...
To evaluate the immunological mechanisms associated with clinical outcomes after autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T- (Treg) and B- (Breg) immune reconstitution, 31 systemic sclerosis (SSc) patients underwent simultaneous evaluations over 36-month posttransplantation follow-up. Patients were retrospectively grouped into responders (n = 25) nonresponders 6), according to response AHSCT. Thymic function B-cell neogenesis respectively assessed by...
Mismatched unrelated donor (MMUD) or umbilical cord blood (UCB) can be chosen as alternative donors for allogeneic stem cell transplantation but might associated with long-lasting immune deficiency. Sixty-six patients who underwent a first from either UCB (n = 30) 9/10 MMUD 36) and survived beyond 3 months were evaluated. Immune reconstitution was prospectively assessed at sequential time points after transplantation. NK, B, CD4(+), CD8(+) T cells their naïve memory subsets, well regulatory...
The determinants of clinical responses after autologous hematopoietic stem cell transplantation (aHSCT) in systemic sclerosis (SSc) are still unraveled. We analyzed long-term immune reconstitution (IR) and T receptor (TCR) repertoire diversity 10 SSc patients, with at least 6 years simultaneous immunological follow-up aHSCT. Patients were retrospectively classified as responders (A, n = 5) or non-responders (B, 5), using modified Rodnan’s skin score (mRSS) forced vital capacity (FVC%). All...
Introduction: Burn injury is associated with a high risk of death. Whether pattern immune and inflammatory responses after burn outcome unknown. The aim this study was to explore the association between systemic in severely-ill patients. Materials Methods: Innate immunity, adaptive activation stress inflammation biomarkers were collected at admission days 2, 7, 14, 28 adult Primary endpoint mortality day 90, secondary infections. Healthy donors (HD) served as controls. Multiple Factorial...
Background. Monitoring of Epstein-Barr virus (EBV) reactivation after allogeneic hematopoietic stem-cell transplantation markedly improved with quantitative real-time polymerase chain reaction amplification EBV DNA and visualization EBV-specific CD8+ T cells peptide-human leukocyte antigen (HLA) class I tetramers. We decided to combine these methods evaluate posttransplant rituximab therapy. Methods. followed 56 patients treated an HLA-genoidentical sibling (n=32), HLA-matched unrelated...
Abstract Adoptive immunotherapy using CTL has provided some clinical benefit to patients with metastatic melanoma. Use of cloned known specificity might improve effect, but technical difficulties have limited exploration this possibility. We used fluorescence-driven cell sorting clone tumor-specific after staining tetrameric MHC class I/peptide complexes. specific for the melanoma Ags melan-A, tyrosinase, and MAGE3 were from peripheral blood, tumor-infiltrated lymph nodes, skin metastases...
Preemptive rituximab (R) treatment decreases the incidence of Epstein-Barr virus (EBV) posttransplantation lymphoproliferative disease, but extent immune deficiency related to R in patients who received allogeneic hematopoietic stem-cell transplantation is unclear. The aim our study was evaluate late infections and reconstitution after preemptive EBV infection.Seventy-eight receiving between January 2005 2010 were studied. Fifty-two them could be matched with controls (not R) according...
Background Due to increased rates of secondary solid organ cancer in patients with severe aplastic anemia who received an irradiation-based conditioning regimen, we decided some years ago use the combination cyclophosphamide and antithymocyte globulin. We report long-term follow up underwent hematopoietic stem cell transplantation from HLA-matched sibling donor after this regimen.Design Methods analyzed 61 consecutive transplanted June 1991 February 2010, following (200 mg/kg) globulin (2.5...
Natural killer cells are the first lymphocyte subset to reconstitute, and play a major role in early immunity after allogeneic hematopoietic stem cell transplantation. Cells expressing activating receptor NKG2C seem crucial resolution of cytomegalovirus episodes, even absence T cells. We prospectively investigated natural killer-cell reconstitution cohort 439 adult recipients who underwent non-T-cell-depleted transplantation between 2005 2012. Freshly collected blood samples were analyzed 3,...
Immune reconstitution after allogeneic stem cell transplantation is a dynamic and complex process depending on the recipient donor characteristics, modalities of transplantation, occurrence graft-versus-host disease. Multivariate methods widely used for gene expression profiling can simultaneously analyze patterns great number biological variables heterogeneous set patients. Here we use these flow cytometry assessment up to 25 lymphocyte populations global pattern long-term immune...
In this study, the immunological status of 61 patients with Fanconi anemia (FA) advanced marrow failure before hematopoietic stem cell transplantation was analyzed by assessing phenotype peripheral blood lymphocytes, serum immunoglobulin (Ig) levels, and inflammatory cytokines. FA, total absolute lymphocytes (P < 0.0001), B cells NK = 0.003) were reduced when compared normal controls. T (CD3), that is, cytotoxic cells, naïve regulatory showed a relative increase Serum levels IgG 0.0001) IgM...