Jean‐Romain Richard
A5028412589- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Genetic Associations and Epidemiology
- Adolescent and Pediatric Healthcare
- Mental Health and Psychiatry
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Migration, Health and Trauma
- Genetics and Neurodevelopmental Disorders
- T-cell and B-cell Immunology
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Toxoplasma gondii Research Studies
- Air Quality and Health Impacts
- Advanced Biosensing Techniques and Applications
- Mental Health Treatment and Access
- Cannabis and Cannabinoid Research
- Climate Change and Health Impacts
- Multiple Sclerosis Research Studies
- Autoimmune Neurological Disorders and Treatments
- Adenosine and Purinergic Signaling
Inserm
2014-2024
Fondation FondaMental
2012-2024
Université Paris-Est Créteil
2012-2024
Assistance Publique – Hôpitaux de Paris
2012-2024
Institut Mondor de Recherche Biomédicale
2017-2024
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2021-2024
Université de Montpellier
2024
Centre National de la Recherche Scientifique
2024
Vinayaka Missions Medical College and Hospitals
2024
Hôpitaux Universitaires Henri-Mondor
2022-2023
Cannabis use is associated with increased risk of later psychotic disorder but whether it affects incidence the remains unclear. We aimed to identify patterns cannabis strongest effect on odds across Europe and explore differences in such contribute variations rates disorder.
Schizophrenia (SCZ) and bipolar disorder (BD) are associated with immunological dysfunctions that have been hypothesized to lead clinical symptomatology in particular through kynurenine pathway abnormalities. The aim of this study was thus investigate the impact serum metabolite levels on diagnosis, state, symptom severity course a large French transdiagnostic cohort SCZ BD patients. Four patient groups (total n = 507) were included cross-sectional observational study: 1) hospitalized acute...
Human endogenous retroviruses (HERVs) are remnants of infections that took place several million years ago and represent around 8% the human genome. Despite evidence implicating increased expression HERV type W envelope (HERV-W ENV) in schizophrenia bipolar disorder, it remains unknown whether such is associated with distinct clinical or biological characteristics symptoms. Accordingly, we performed unsupervised two-step clustering a multivariate data set included HERV-W ENV protein...
Abstract Precision psychiatry is attracting increasing attention lately as a recognized priority. One of the goals precision to develop tools capable aiding clinically informed psychiatric diagnosis objectively. Cognitive, inflammatory and immunological factors are altered in both bipolar disorder (BD) schizophrenia (SZ), however, most these alterations do not respect diagnostic boundaries from phenomenological perspective possess great variability different individuals with same phenotypic...
Schizophrenia and bipolar disorder frequently face significant delay in diagnosis, leading to being missed or misdiagnosed early stages. Both disorders have also been associated with trait state immune abnormalities. Recent machine learning-based studies shown encouraging results using diagnostic biomarkers predictive models, but few focused on immune-based markers. Our main objective was develop supervised learning models predict diagnosis illness schizophrenia only a panel of peripheral...
Article Abstract Objective: Schizophrenia and bipolar disorder are associated with cognitive impairment leading to social disruption. While previous studies have focused on the effect of individual infectious exposure, namely, Herpesviridae viruses or Toxoplasma gondii (T gondii), functioning, objective present study was examine multiple infections functioning in patients schizophrenia healthy controls. Methods: Seropositivity herpes simplex virus type 1 (HSV-1), 2 (HSV-2), cytomegalovirus...
Mitochondria (Mt) are intra-cellular components essential for cellular energy processes whose dysfunction may induce premature senescence and/or inflammation, both observed in bipolar disorders (BD). We investigated mitochondrial DNA copy number (mtDNAcn) levels patients with BD being manic, depressive or euthymic phase and healthy controls (HC) characterized the of blood-based inflammatory markers stigma pathogens. 312 were compared to 180 HC. mtDNAcn measured using a digital droplet PCR....
Abstract Epidemiology has repeatedly associated certain infections with a risk of further developing psychiatric diseases. Such can activate retro-transposable genetic elements (HERV) known to trigger immune receptors and impair synaptic plasticity neuroreceptors. Since the HERV-W ENV protein was recently shown co-cluster pro-inflammatory cytokines in subgroup patients schizophrenia or bipolar disorder, we questioned influence COVID-19 pandemic on psychosis spectrum disorders (PSD). Present...
The object of this study is test whether mitochondrial blood-based biomarkers are associated with markers metabolic syndrome in bipolar disorder, hypothesizing higher lactate but unchanged cell-free circulating DNA levels disorder patients syndrome. In a cohort study, primary testing from the FondaMental Advanced Centers Expertise for (FACE-BD) was conducted, including 837 stable patients. I-GIVE validation consists 237 participants: and acute patients, non-psychiatric controls,...
The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset disorder, potentially ignoring important confounding relationships or fact that some may be consequence disorder rather than preexisting. study subclinical could help to address these issues. In this study, we investigated whether there was (i) an association between dimensions several including: childhood trauma, self-reported discrimination experiences, low social capital,...
Our aim was to, firstly, identify characteristics at first-episode of psychosis that are associated with later antipsychotic treatment resistance (TR) and, secondly, to develop a parsimonious prediction model for TR.
Immune dysregulation is an important aspect of schizophrenia (SZ) and bipolar disorders (BD) pathophysiology, including not only inflammatory but also autoimmune process reflective abnormal humoral immune responses. Given that B cell-activating factor (BAFF) integral lymphocyte regulation, the current study investigated BAFF in SZ BD. 255 patients, 407 BD patients 185 healthy controls (HC) were across three aspects soluble (sBAFF) by (i) comparing sBAFF circulatory levels SZ, HC, (ii)...
Abstract Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from EU-GEI study, we evaluated impact schizophrenia polygenic risk score (SZ-PRS) and patterns cannabis use on transdiagnostic We analysed first-episode psychosis patients (FEP) controls, generating dimensions psychotic symptoms experiences using item response bi-factor modelling. Linear regression was used to test associations between these SZ-PRS, as well combined effect SZ-PRS...
Evidence suggests that childhood maltreatment (ie, abuse and neglect) affects educational attainment cognition. However, the association between Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: poor cognition would be community than first-episode of psychosis (FEP); abuse, neglect show associations cognition; IQ partially accounted for by other risk factors; maltreatment, attainment, patients affective psychoses those...
Gene x environment (G×E) interactions, i.e. genetic modulation of the sensitivity to environmental factors and/or control gene expression, have not been reliably established regarding aetiology psychotic disorders. Moreover, recent studies shown associations between polygenic risk scores for schizophrenia (PRS-SZ) and some disorders, challenging traditional v. dichotomy. In present article, we studied role GxE interaction psychosocial stressors (childhood trauma, stressful life-events,...
Immune dysfunction could play a significant role in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ), conditions with an underlying pro-inflammatory state. Studies on humoral immune responses (which reflects antibody mediated fight against pathogens) are sparse often providing contradictory results. The aim this study was to assess immunity group stable patients compared controls by determining total Immunoglobulins IgG subclasses their association latent Toxoplasma gondii...