A5036109282- Cystic Fibrosis Research Advances
- Child Nutrition and Feeding Issues
- Agriculture and Rural Development Research
- Family and Disability Support Research
- Neonatal Respiratory Health Research
- Childhood Cancer Survivors' Quality of Life
- Tracheal and airway disorders
- Interprofessional Education and Collaboration
- French Urban and Social Studies
- Pediatric health and respiratory diseases
- Agriculture and Farm Safety
- Mobile Health and mHealth Applications
- Vector-Borne Animal Diseases
- Airway Management and Intubation Techniques
- Health, Medicine and Society
- Respiratory viral infections research
- Genetic and phenotypic traits in livestock
- Nematode management and characterization studies
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Food Allergy and Anaphylaxis Research
- Information Technology and Learning
- Adolescent and Pediatric Healthcare
- Vector-borne infectious diseases
Edmond and Lily Safra Children's Hospital
2025
Centre Hospitalier Universitaire de Nantes
2008-2024
Institut de l’Elevage
2007-2023
Institut Technique de l'Aviculture
2023
Centre National de la Recherche Scientifique
1996-2022
Université de Bordeaux
2022
École Pratique des Hautes Études
2022
Environnements et Paléoenvironnements Océaniques et Continentaux
2022
Nantes Université
2018-2021
Université de Picardie Jules Verne
2020
Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic (CF) homozygous the Phe508del mutation.Objectives: To evaluate safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) adults (≥18 real-life postapproval setting.Methods: The study was conducted 47 CF reference centers France. All who initiated from January 1 to December 31, 2016, were eligible. Patients evaluated...
Introduction Capgras syndrome (CS) is characterized by the delusional belief that a person, usually close relative, has been replaced an imposter. This study focuses on co-occurrence of CS and Obsessive-Compulsive Disorder (OCD) in children. Methods We present two cases children diagnosed with OCD treated at our inpatient child psychiatric unit. Cases presentation describe 11-year-old male who believed his parents were demonic entities 12-year-old female her robots. Both exhibited additional...
Abstract Until the year 2000, systematic cystic fibrosis (CF) neonatal screening was only performed in a few regions of France. The Brittany region began 1989, but not neighboring Loire‐Atlantique. present study compares clinical evolution both affected populations 10 years after started. Although 77 screened and 36 nonscreened children were followed different CF centers, they included similar care protocols. characteristics at diagnosis their over 10‐year period all with born between...
A study was carried out to assess the efficacy of vaccination, using a phase I Coxiella burnetii-inactivated vaccine (Coxevac®; CEVA), within three goat herds experiencing Q fever abortions waves. The stratification population (n = 905) based on parity and infection status related both serological qPCR vaginal shedding results. Control 443) vaccinated 462) groups were established in each farm. Vaccination administered does before mating kids after active immunity acquisition (at least 3 4...
This study, carried out in three goat herds, was aimed at describing individual responses to Q fever infection an abortive context, focusing on both antibody and shedding levels. Seroprevalence of Coxiella burnetii (Cb) vaginal 1083 goats were investigated using ELISA realtime qPCR assays, respectively. At the end outbreaks, a seroprevalence 45.0% found, appeared massive with levels above 10(4) Cb per swab 42.3% whole population 10(6) for 90.9% aborted goats. Susceptible animals (i.e....
Bovine mastitis is mainly caused by bacterial infection and responsible for important economic losses as well alterations of the health welfare animals. The increase in somatic cell count (SCC) milk during due to influx neutrophils, which have a crucial role elimination pathogens. For long time, these first-line defenders been viewed microbe killers, with limited orchestration immune response. However, their more complex: we recently characterized bovine neutrophil subset expressing major...
Abstract Many patients with maternal uniparental disomy of chromosome 7 (UPD7) have been described, mainly intrauterine and postnatal growth retardation or Silver–Russell syndrome. In contrast, only three cases paternal UPD7 reported, all associated recessive disorders. Here, we report on the clinical molecular data third patient cystic fibrosis. Pre‐ were normal. These findings support hypothesis that isodisomy for human may no phenotypic effect growth. © 2007 Wiley‐Liss, Inc.
Many studies have shown that congenital absence of the vas deferens (CAVD) is a genital cystic fibrosis transmembrane conductance regulator (CFTR)-mediated phenotype, with broad spectrum abnormalities causing male infertility. The genotype these patients includes mutations in CFTR gene, e.g. ΔΔF508, R117H and T5 allele; all which are commonly found CAVD. In this study we screened entirety gene 47 males anomalies deferens: 37 cases bilateral deferens, three unilateral seven obstructive...
Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has demonstrated clinical benefits in phase 3 trials. We report results from real-world study (BRIO) to assess the effectiveness of ivacaftor people with (pwCF) France. BRIO was an observational conducted at 35 centers Both pwCF initiating treatment and those already taking were included prospectively followed for 24 months. The primary objective evaluate effect on percent predicted forced expiratory...
Introduction: Life expectancy in patients suffering from cystic fibrosis has very much increased. It can now be compared to diabetes, requiring a lot of time spent with treatments and special skills that need acquired by families. Objectives: To promote structured therapeutic education fibrosis. Methods: Our Cystic Fibrosis (CF) center proposed since 2006, alternating individual group sessions, organized the initial diagnosis transition paediatric adult care. During hygiene precautions are...
The two pediatric cystic fibrosis centers (CFCs) in Paris (Robert Debré) and Nantes, France, have been developing therapeutic patient education (TPE) programs since 2006 engaged the pilot phase of quality improvement program (QIP) named Hospital Program to Improve Outcomes Expertise Cystic Fibrosis (PHARE-M) 2011. objective was improve FEV1 cohort adolescents prepare them for their optimal transition an adult CFC. CFCs formed a multidisciplinary team used analysis causes insufficient...
Introduction Simulation is rarely used to help individuals with chronic diseases develop skills. The aim of the study was provide recommendations for use simulation in therapeutic patient education (S-TPE). Methods Expert consensus achieved participation following 3 groups experts: ( a ) expert patients and caregivers; b health professionals specialized (TPE); c experts. Each received list questions by e-mail iterations. synthesis 2 first questionnaires resulted 34 voted during conference...