A5050638269- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Traumatic Brain Injury Research
- Healthcare Systems and Practices
- Cardiac Arrest and Resuscitation
- Respiratory viral infections research
- Malaria Research and Control
- Influenza Virus Research Studies
- Antibiotic Resistance in Bacteria
- Global Maternal and Child Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Urinary Tract Infections Management
- Salmonella and Campylobacter epidemiology
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Data-Driven Disease Surveillance
- Bacterial Infections and Vaccines
- Health, Medicine and Society
- Emergency and Acute Care Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Patient Satisfaction in Healthcare
- Tactile and Sensory Interactions
- Parasites and Host Interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Food Safety and Hygiene
Inserm
2016-2025
Université de Versailles Saint-Quentin-en-Yvelines
2016-2025
Université Paris Cité
2005-2025
Université Paris-Saclay
2016-2025
Institut Pasteur
2016-2025
Centre de recherche en Epidémiologie et Santé des Populations
2011-2025
Sorbonne Paris Cité
2013-2024
CNR de la Résistance aux Antibiotiques
2021-2023
Université Paris-Sud
2009-2022
Equipe de Recherche en Epidémiologie Nutritionnelle
2022
Background Overuse of antibiotics is the main force driving emergence and dissemination bacterial resistance in community. France consumes more has highest rate beta-lactam Streptococcus pneumoniae than any other European country. In 2001, government initiated “Keep Antibiotics Working”; program's component was a campaign entitled “Les antibiotiques c'est pas automatique” (“Antibiotics are not automatic”) launched 2002. We report evaluation this by analyzing evolution outpatient antibiotic...
Antibiotic misuse in lower- and middle-income countries (LMICs) contributes to the development of antibiotic resistance that can disseminate globally. Strategies specific LMICs seek reduce by humans, but simultaneously improve access, have been proposed. However, most approaches date not considered growing impact animal environmental reservoirs resistance, which threaten exacerbate crisis LMICs. In particular, current strategies do prioritize impacts increased use for terrestrial food-animal...
Respiratory syncytial virus (RSV) is the main cause of infant and child hospitalizations. The study objective to estimate RSV-associated hospitalizations economic burden in young children France inform future preventive strategies.We conducted a retrospective analysis data from French Hospital database (PMSI-MCO) which covers entire population. All aged < 5 years hospitalized with RSV ICD-10 codes (J210, J219, J45, J121, J205, R062) 2010 2018, were included. Descriptive analyses by seasons...
Antibiotic resistance (ABR) is a major concern for global health. However, factors driving its emergence and dissemination are not fully understood. Identification of such crucial to explain heterogeneity in ABR rates observed across space, time, species antibiotics.We analysed count data clinical isolates from 51 countries over 2006-19 thirteen drug-bacterium pairs taken the ATLAS database. We characterised spatial temporal patterns used mixed-effect negative binomial model, accounting...
Studies with animal models have suggested the possibility of interactions between parasites during concurrent infections and raised question a similar phenomenon in humans. The present survey was undertaken to assess impact urinary schistosomiasis on susceptibility children malaria. It carried out Senegal September 2001 March 2002 among 523 3-15 years age. We tested association Plasmodium falciparum densities load Schistosoma haematobium egg excretion using linear mixed model because data...
The development of novel approaches that combine epidemiological and genomic data provides new opportunities to reveal the spatiotemporal dynamics infectious diseases determine processes responsible for their spread maintenance. Taking advantage detailed time series viral sequence from more than 20 years reported by National Reference Centre Rabies Bangui, capital city Central African Republic, we used a combination mathematical modeling phylogenetic analysis rabies in domestic dogs as well...
Salmonella enterica is a leading cause of human gastroenteritis. S. strains that produce ESBLs (ESBL-Salm) remain rare in Europe and North America, but less known about their prevalence among animal-derived foods countries with weaker food safety practices unregulated veterinary antibiotic use. To examine the characteristics ESBL-Salm from retail meats Phnom Penh, Cambodia. We tested fish, pork chicken two markets for ESBL- carbapenemase-producing September–December 2016, using cefotaxime-...
In France, despite several successive plans to control antimicrobial resistance, antibiotic use remains high in the outpatient setting. This study aims better understand and prescription order identify tailored targets for future public health actions. Using data from French National Health Data System, we described compared individual characteristics of patients with without an prescription. The prescribed antibiotics (ATC-J01) were detailed between 2019 2020. Antibiotic prescribing...
The temporal and spatial association of meningococcal disease influenza-like syndrome (ILS) was assessed from surveillance data on these diseases in France for a 6-year period (1985-1990). Using time series methods to account the usual seasonal pattern disease, incidence given week found be linked ILS 5 previous weeks but not that subsequent weeks. Geographic spread correlated with ILS. This study also suggests is more severe 2-month during after an epidemic: proportion cases purpura...
Background The association between placental malaria (PM) and first peripheral parasitaemias in early infancy was assessed Tori Bossito, a rural area of Benin with careful attention on transmission factors at an individual level. Methodology Statistical analysis performed 550 infants followed weekly from birth to 12 months. Malaria by anopheles human landing catches every 6 weeks 36 sampling houses season defined rainfall. Each child located GPS assigned the closest house. Data were analysed...
Abstract To determine the effect of maternal anaemia on pregnancy outcome and describe its impact infant haemoglobin level in first 18 months life, we conducted a prospective study 617 pregnant women their children Benin. Prevalence at delivery was 39.5%, 61.1% newborns were anaemic birth. Maternal not associated with low birth weight [OR = 1.2 (0.6–2.2)] or preterm 1.3 (0.7–2.4)], whereas newborn’s related to 1.8 (1.2–2.5)]. There no association between an infant’s until anaemia. However,...
Pneumococcal meningitis (PM) is a major invasive pneumococcal disease. Two conjugate vaccines (PCVs) have been introduced in France: PCV7 was recommended 2003 and replaced 2010 by PCV13, which has six additional serotypes. The impact of introducing those on the evolution PM case numbers serotype distributions France from 2001 to 2014 assessed herein. Data 5166 Streptococcus pneumoniae strains isolated cerebrospinal fluid between 22 regions were obtained National Reference Center for...
Infections caused by Streptococcus pneumoniae —including invasive pneumococcal diseases (IPDs)—remain a significant public health concern worldwide. The marked winter seasonality of IPDs is striking, but still enigmatic aspect epidemiology in nontropical climates. Here we confronted age-structured dynamic models carriage transmission and disease with detailed IPD incidence data to test range hypotheses about the components mechanisms seasonality. We find that seasonal variations climate,...
ObjectivesHigh-dose quadrivalent influenza vaccine (HD-QIV) was introduced during the 2021/22 season in France for adults aged ≥65 years as an alternative to standard-dose vaccines (SD-QIV). The aim of this study is estimate relative effectiveness (rVE) HD-QIV versus SD-QIV against influenza-related hospitalisations France.MethodsCommunity-dwelling individuals with reimbursed claims were included from French national health insurance database. Individuals followed up vaccination day 30 June...
A controlled randomized trial of antihelminthic treatment was undertaken in 1996-1997 a rural area Madagascar where populations were simultaneously infected with Ascaris lumbricoides and Plasmodium falciparum. Levamisole administered bimonthly to 164 subjects, on family basis, whereas 186 controls. While levamisole proved be highly effective reducing egg loads the treated group (P < 10(-3) at all visits), subjects more than 5 years age, had significant increase their P. falciparum densities...
Objective Self-reported stressful life events and infections have been associated with relapses in multiple sclerosis. Also, anxiety has reported to influence other diseases of unpredictable course. To study relation self-reported events, levels anxiety, episodes infection, the disease women Methods This is a one-year prospective study. Thirty seven sclerosis were regularly seen every four weeks, for one year. They keeping diaries they considered stressful. These ranked according Holmes Rahe...
Temporal processing deficit could be associated with a specific difficulty in learning to read. In 1951, Stambak provided preliminary evidence that children dyslexia performed less well than good readers reproduction of 21 rhythmic patterns. Stambak's task was administered 1,028 French aged 5–6 years. The score distribution (from 0 21) quasi-normal, some failing completely and other performing perfectly. second grade, reading assessed 695 these children. Kindergarten variables explained 26%...
A controlled randomized trial of anti-helminthic treatment was undertaken in 1996-1997 a rural area Madagascar where populations were simultaneously infected with Ascaris lumbricoides, Plasmodium falciparum, and Schistosoma mansoni. Levamisole administered bimonthly to 107 subjects, whereas 105 controls. highly effective reducing egg loads the treated group (P < 10(-3) at all visits), it had no effect on schistosomiasis. Subjects 5-14 years age, levamisole, significant increase their P....
Parasitic infections are associated with high morbidity and mortality in developing countries. Several studies focused on the influence of helminth malaria but nature biological interaction is under debate. Our objective was to undertake a study explore measure excreted egg load caused by Schistosoma haematobium Plasmodium falciparum parasite densities. Ten measures density two schistosomiasis urinary excretion over 2-year follow-up period 178 Senegalese children were considered. A linear...
Objective In the context of rapid changes regarding practices related to delivery in Africa, we assessed maternal and perinatal adverse outcomes associated with mode 41 referral hospitals Mali Senegal. Study Design Cross-sectional survey nested a randomised cluster trial (1/10/2007–1/10/2008). The associations between intended (i) in-hospital mortality, (ii) morbidity (transfusion or hysterectomy), (iii) stillbirth neonatal death before Day 1 (iv) 24 hours after birth hospital discharge were...
Individuals who survive sepsis are at high risk of chronic sequelae, resulting in significant health-economic costs. Several studies have focused on aspects healthcare pathways survivors but comprehensive, longitudinal overview their care scarce. The aim this retrospective, cohort study is to identify survivor profiles based and describe consumption costs over the 3 years following index hospitalization.The data were extracted from French National Hospital Discharge Database. population...
Few epidemiological studies have investigated the long-term outcome of primary glomerulonephritis (GN) and its determinants in decade since angiotensin-converting enzyme inhibitors entered widespread use.To study several traditional less risk factors for kidney disease progression a cohort patients with GN.Retrospective study.We included 536 GN first diagnosed between 1994 2001: 283 IgA nephropathy (IgA), 129 membranous (MN), 124 focal segmental glomerulosclerosis (FSGS). Adjusted hazard...