A5072666297- Prion Diseases and Protein Misfolding
- Cultural Insights and Digital Impacts
- Trace Elements in Health
- RNA regulation and disease
- Aging, Elder Care, and Social Issues
- French Urban and Social Studies
- Antibiotic Use and Resistance
- Diagnosis and Treatment of Venous Diseases
- Community Development and Social Impact
- Animal Genetics and Reproduction
- Wikis in Education and Collaboration
- Names, Identity, and Discrimination Research
- FinTech, Crowdfunding, Digital Finance
- Healthcare Systems and Practices
- Open Education and E-Learning
- Diverse Cultural and Historical Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory and Cough-Related Research
- Venous Thromboembolism Diagnosis and Management
- Linguistics and Cultural Studies
- Metallurgy and Material Science
- Digital Humanities and Scholarship
- Natural Language Processing Techniques
- Private Equity and Venture Capital
- Monoclonal and Polyclonal Antibodies Research
GEDI Gruppo Editoriale (Italy)
2014
Risques Travail Marchés Etat
2011
Inserm
2009
Institut Pasteur
2009
Virologie et Immunologie Moléculaires
2000-2007
Institut National de la Recherche Agronomique
2004-2005
Background Overuse of antibiotics is the main force driving emergence and dissemination bacterial resistance in community. France consumes more has highest rate beta-lactam Streptococcus pneumoniae than any other European country. In 2001, government initiated “Keep Antibiotics Working”; program's component was a campaign entitled “Les antibiotiques c'est pas automatique” (“Antibiotics are not automatic”) launched 2002. We report evaluation this by analyzing evolution outpatient antibiotic...
Prion diseases are fatal neurodegenerative disorders of animals and humans that characterized by the conversion host-encoded prion protein (PrP) to an abnormal isoform. In several species, including humans, polymorphisms in gene encoding PrP tightly control susceptibility individuals toward this disease. present study we show Rov cells expressing ovine allele ((VRQ)PrP) associated with high sheep scrapie were very sensitive transmission replicated agent titers. contrast, did not find any...
A key feature of prion encephalopathies is the accumulation a misfolded form host glycoprotein PrP. Cell-free and cell culture studies have shown that efficiency conversion PrP into disease-associated influenced by its amino acid sequence also carbohydrate moiety. Here, we characterize four novel glycoform-dependent monoclonal antibodies raised against prokaryotic recombinant sheep We demonstrate these discriminate monoglycosylated species, since two them recognize molecules first Asn...
During prion infections, the cellular glycosylphosphatidylinositol-anchored glycoprotein PrP is converted into a conformational isoform. This abnormal conformer thought to recruit and convert normal likeness of itself proposed be infectious agent. We investigated distribution protein on surface Rov cells, an epithelial cell line highly permissive multiplication, we found that primarily expressed apical side. further show transmission cells much more efficient if infectivity contacts side,...
Le Comité consultatif de déontologie et d’éthique (CCDE) l’Institut recherche pour le développement (IRD) a publié en juin 2013 un avis qui constitue, fait, la première prise position officielle d’un établissement français au sujet du crowdfunding. financement participatif apparaissant plus comme une potentielle source fonds des projets recherche, cet trace deux limites éthiques : l’absence d’évaluation par pairs possibilité manipuler les donateurs discours marketing promesses sans...
Comment entrer dans l’intimite d’un chercheur ? rendre compte de la vision du monde qui est sienne acceder a une authentique recherche en train se faire A ces questions, le realisateur Mathias Thery donne quelques elements reponse ses deux films, La vie apres mort d’Henrietta Lacks (ci-apres VAMHL) et Cherche toujours (CT). Le premier constitue son film d’etudes l’Ecole nationale superieure des arts decoratifs. second commande collectif « Sauvons », seduit par travail effectue sur VAMHL, ete...
Les Encéphalopathies Spongiformes Transmissibles (EST) sont des maladies neurodégénératives caractérisées par l’accumulation dans le cerveau d’une forme anormale de la protéine prion, PrP. La PrP cellulaire est une glycoprotéine membranaire qui a deux sites glycosylation. susceptibilité moutons à tremblante, plus répandue EST, sous contrôle d’un polymorphisme génétique en position 136, 154 et 171 Différents travaux ont montré que l’efficacité conversion normale (PrPc) (PrPsc) pouvait être...