A5102731931- Antibiotic Resistance in Bacteria
- Escherichia coli research studies
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
- Antibiotic Use and Resistance
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Salmonella and Campylobacter epidemiology
- Urinary Tract Infections Management
- Reproductive tract infections research
- Hepatitis C virus research
- Pneumonia and Respiratory Infections
- Neonatal and Maternal Infections
- Syphilis Diagnosis and Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Global Maternal and Child Health
- Vaccine Coverage and Hesitancy
- Bacterial Infections and Vaccines
- Gastroesophageal reflux and treatments
- Streptococcal Infections and Treatments
Cheikh Anta Diop University
2016-2025
Institut Pasteur de Dakar
2015-2024
National University Hospital
2023
Hôpital Aristide Le Dantec
2012-2023
Institut Pasteur
2010-2021
Inserm
1990
Antibiotic misuse in lower- and middle-income countries (LMICs) contributes to the development of antibiotic resistance that can disseminate globally. Strategies specific LMICs seek reduce by humans, but simultaneously improve access, have been proposed. However, most approaches date not considered growing impact animal environmental reservoirs resistance, which threaten exacerbate crisis LMICs. In particular, current strategies do prioritize impacts increased use for terrestrial food-animal...
Background: Klebsiella pneumoniae (hereafter, Kp) is a major public health threat responsible for high levels of multidrug resistant (MDR) human infections. Besides, Kp also causes severe infections in the community, especially Asia and Africa. Although most are caused by endogenous intestinal carriage, little known about prevalence microbiological characteristics asymptomatic attached risk factors including environmental sources exposure.Methods: Here, 911 pregnant women from communities...
Salmonella enterica is a leading cause of human gastroenteritis. S. strains that produce ESBLs (ESBL-Salm) remain rare in Europe and North America, but less known about their prevalence among animal-derived foods countries with weaker food safety practices unregulated veterinary antibiotic use. To examine the characteristics ESBL-Salm from retail meats Phnom Penh, Cambodia. We tested fish, pork chicken two markets for ESBL- carbapenemase-producing September–December 2016, using cefotaxime-...
Antibiotic combination therapy for Helicobacter pylori eradication must be adapted to local resistance patterns, but the epidemiology of H. antibiotics is poorly documented in Africa. The aim was determine antibiotic rates, as well associated molecular mechanisms, strains isolated Dakar, Senegal.One hundred and eight were between 2007 2009 from 108 patients presenting with upper abdominal pain Gastroenterology Department Le Dantec Hospital. Antimicrobial susceptibility testing performed...
Between December 2009 and November 2011, we collected 57 (12.3%) Staphylococcus aureus isolates from 464 pigs 16 (30.8%) 52 farmers in the largest farm Dakar. Fifty-one (70%) belonged to four major multilocus sequence typing clonal complexes (CCs): CC152 (26.0%), CC15 (19.2%), CC5 (13.7%), CC97 (10.9%). The CC variability among was similar that observed farmers. Six were recovered only resistant methicillin (10.5%). They assigned ST5-staphylococcal cassette chromosome mec type (SCCmec) IV...
HBV vaccine was introduced into the Expanded Programme on Immunization (EPI) in Senegal and Cameroon 2005. We conducted a cross-sectional study both countries to assess immune protection among children. All consecutive children under 4 years old, hospitalized for any reason between May 2009 2010, with an immunisation card complete vaccination, were tested anti-HBs anti-HBc. A total of 242 anti-HBc-negative (128 114 Senegal) considered analysis. The prevalence ≥ 10 IU/L higher 92% (95% CI:...
Background: Data regarding the evolution of antimicrobial resistance are needed to suggest appropriate empirical treatment urinary tract infections (UTI) in developing countries. To assess susceptibility Escherichia coli, predominant pathogen community-acquired UTI, a prospective multicenter study was carried out Dakar, Senegal. Methodology: From February 2004 October 2006, 1010 non-duplicate E. coli strains were collected from four centres. Antimicrobial testing performed using disk...
Background: In sub-Saharan Africa, infectious diarrhoea is a major cause of childhood morbidity and mortality. A cross-sectional study was undertaken to document the pathogens potentially involved in community-acquired Dakar, capital Senegal.Methods: Between September 2007 March 2008, 176 children aged 1 month 5 years were recruited consecutively from primary health care institution an urban area. Clinical data recorded stool samples collected. Bacterial identified using conventional methods...
Limited access to nucleic acid tests for hepatitis B virus (HBV) DNA is a significant barrier the effective management of chronic HBV infection in resource-poor countries. Alternatively, e antigen (HBeAg) may accurately indicate high viral replication. We assessed diagnostic performance three commercially available rapid (RDTs) HBeAg (SD Bioline, Insight and OneStep) against quantitative chemiluminescent immunoassay (CLIA, Architect). Using stored sera from adults with infection, we tested...
Neonatal infection constitutes one of Senegal's most important public health problems, with a mortality rate 41 deaths per 1,000 live births. Between January 2007 and March 2008, 242 neonates suspected were recruited at three neonatal intensive care units in major tertiary centers Dakar, the capital Senegal. infections confirmed by positive bacterial blood or cerebrospinal fluid culture. The microbiological pattern antibiotic susceptibility isolates characterized. In addition, genetic basis...
Background: Urinary Tract Infections (UTIs) are common bacterial infections, primarily caused by Gram-negative bacteria, such as Escherichia coli. They affect approximately 150 million individuals worldwide annually, leading to high healthcare costs and significant morbidity. The standard diagnostic method, urine culture, has a turnaround time of 48-72 hours, often necessitating empirical antibiotic treatment, which may contribute resistance. Rapid, accurate tools essential improve clinical...
Background Severe bacterial infections (SBIs) are a leading cause of neonatal deaths in low- and middle-income countries (LMICs). However, most data came from hospitals, which do not include neonates who did seek care or were treated outside the hospital. Studies community scarce, few among those available conducted with high-quality microbiological techniques. The burden SBI at level is therefore largely unknown. We aimed here to describe incidence, etiology, risk factors, antibiotic...
Vaccination reduces mortality from infectious disease, which is the leading cause of death in children under 5 and bears a particularly high burden low- middle-income countries. The Global Vaccine Action Plan (2011-2020) has set target 90% vaccine coverage for all vaccines included national immunization programs by 2020. objectives this study were to estimate among Madagascar, Cambodia, Senegal identify risk factors associated with incomplete vaccination.
Background: Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in development gastric cancer. A high frequency H. infection has been reported from resource-poor regions. curable with regimens multiple antimicrobial agents. However, antibiotic resistance a leading treatment failure. In Africa, there are very little data concerning susceptibility isolates to antibiotics.Methodology: biopsies outpatients ≥ 18 years old affected by gastro-duodenal were used...
Hepatitis B is a major health concern in Africa. The vaccine against hepatitis virus (HBV) was introduced into the Expanded Programme on Immunization (EPI) of Cameroon and Senegal 2005, CAR (Central African Republic) 2008. A cross-sectional study conducted to assess HBV immunization coverage following vaccine’s introduction EPI factors associated with having been vaccinated. All hospitalized children, regardless reasons for their hospitalization, between 3 months 6 years age, whom blood test...
Salmonella enterica is the most common foodborne pathogen worldwide. It causes two types of diseases, a self-limiting gastroenteritis and an invasive, more threatening, infection. caused by several serotypes In contrast, invasive salmonellosis rare in high-income countries (HIC) while frequent low- middle-income (LMIC), especially sub-Saharan Africa (sSA). Invasive Nontyphoidal (iNTS), corresponding to other than Typhi Paratyphi, have emerged sSA pose significant risk public health. We...
The incidence of the Salmonella contamination poultry products in Senegal is unknown. and antimicrobial drug resistance profiles chicken carcasses were investigated. Between July 2012 2013, three types (broilers, laying hens, premises chickens) obtained from retailers markets Dakar its suburbs tested for contamination. strains isolated 300 according to International Organization Standardization ISO 6579 (2002) guidelines. In these samples, 273 isolates obtained, belonging 22 serovars, 53%...
To assess antibiotic susceptibility of community-acquired respiratory tract isolates from Ivory Coast, Kenya, Democratic Republic Congo (DRC) and Senegal in 2011-14.Bacterial were collected MICs determined using Etest(®) for all antibiotics except erythromycin, which testing was by disc diffusion. Susceptibility assessed CLSI, EUCAST pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide interpretation, CLSI breakpoints adjusted incubation CO2.Susceptibility to penicillin (using...