A5066244994- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Axon Guidance and Neuronal Signaling
- Quantum Chromodynamics and Particle Interactions
- Tryptophan and brain disorders
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Advanced Neuroimaging Techniques and Applications
- Down syndrome and intellectual disability research
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Alzheimer's disease research and treatments
- Trace Elements in Health
- Biochemical Analysis and Sensing Techniques
Centro de Investigación Biomédica en Red de Salud Mental
2016-2025
Universitat de València
2016-2025
Centro de Investigación Biomédica en Red
2025
INCLIVA Health Research Institute
2015-2024
Spanish Clinical Research Network
2015-2024
Instituto de Salud Carlos III
2021-2024
Instituto de Investigación Sanitaria Aragón
2024
Hospital Clínico Universitario de Valencia
2012-2023
National Center for Genetic Engineering and Biotechnology
2023
Institute for Biomedicine
2023
Cannabis use is associated with increased risk of later psychotic disorder but whether it affects incidence the remains unclear. We aimed to identify patterns cannabis strongest effect on odds across Europe and explore differences in such contribute variations rates disorder.
Abstract Chronic restraint stress has been shown to induce structural remodelling throughout the interconnected dentate gyrus‐CA3 fields. To find out how this stressor affects rate of adult hippocampal neurogenesis, we subjected rats acute or chronic and assessed proliferation, survival differentiation newly born cells in gyrus. We also examined polysialylated neural cell adhesion molecule expression, a normally expressed immature neurons important for morphological plasticity. The results...
Abstract Doublecortin (DCX) is a protein required for normal neuronal migration in the developing cerebral cortex, where it widely expressed both radially and tangentially migrating neuroblasts. Moreover, has been observed adult rostral migratory stream, which contains precursors traveling to olfactory bulb. We have performed DCX immunocytochemistry rat brain identify precisely populations expressing this protein. Our observations confirm presence of immunoreactive cells with characteristic...
During adulthood, neural precursors located in the subgranular zone of dentate gyrus continue to proliferate, leading generation new granule neurons. These recently generated cells transiently express polysialylated form cell adhesion molecule, PSA-NCAM, and are supported by radial glia-like that likely play a role neuronal migration differentiation, or even act as their precursors. Previous reports indicate treatment with NMDA receptor antagonists stimulates adult neurogenesis gyrus,...
Abstract Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underlying mechanisms have remained obscure. Here, we show with novel line reporter mice that cognitive challenge induces local/endogenous hypoxia hippocampal pyramidal neurons, hence enhancing expression and receptor (EPOR). High-dose administration, amplifying auto/paracrine EPO/EPOR...
Novel hypotheses suggest that antidepressants, such as the selective serotonin reuptake inhibitor fluoxetine, induce neuronal structural plasticity, resembling of juvenile brain, although underlying mechanisms this reopening critical periods still remain unclear. However, recent studies inhibitory networks play an important role in plasticity induced by fluoxetine. For reason we have analysed effects a chronic fluoxetine treatment hippocampus and medial prefrontal cortex (mPFC) transgenic...
Parvalbumin-expressing (PV+) interneurons play a key role in the maturation and synchronization of cortical circuitry alterations these inhibitory neurons, especially medial prefrontal cortex (mPFC), have been found different psychiatric disorders. The formation perineuronal nets (PNNs) around many at end critical periods reduces their plasticity sets connectivity. Consequently, presence PNNs must an important impact on synaptic input physiology PV+ cells. In present study, we that adult...
New neurons in the adult brain transiently express molecules related to neuronal development, such as polysialylated form of neural cell adhesion molecule, or doublecortin (DCX). These are also expressed by a population rat paleocortex layer II, whose origin, phenotype, and function not clearly understood. We have classified most these cells new type termed tangled cell. Some with morphology semilunar–pyramidal transitional were found among this population, well some scarce resembling...
Principal neurons in the adult cerebral cortex undergo synaptic, dendritic, and spine remodeling response to different stimuli, several reports have demonstrated that polysialylated form of neural cell adhesion molecule (PSA-NCAM) participates these plastic processes. However, there is only limited information on expression this interneurons its role structural plasticity cells. We found PSA-NCAM expressed mature widely distributed all extension excluded most principal Although generally...
The exposure to aversive experiences during early life influences brain development and leads altered behavior. Moreover, the combination of these with subtle alterations in neurodevelopment may contribute emergence psychiatric disorders, such as schizophrenia. Recent hypotheses suggest that imbalances between excitatory inhibitory (E/I) neurotransmission, especially prefrontal cortex amygdala, underlie their etiopathology. In order understand better neurobiological bases alterations, we...
Neurogenesis in the healthy adult murine brain is based on proliferation and integration of stem/progenitor cells thought to be restricted 2 neurogenic niches: subventricular zone dentate gyrus. Intriguingly, expressing immature neuronal marker doublecortin (DCX) polysialylated-neural cell adhesion molecule reside layer II piriform cortex. Apparently, these progressively disappear along course ageing, while their fate function remain unclear. Using DCX-CreERT2/Flox-EGFP transgenic mice, we...
The adult mammalian brain is mainly composed of mature neurons. A limited amount stem cell-driven neurogenesis persists in postnatal life and reduced large-brained species. Another source immature neurons brains cortical layer II. These (cINs) retain developmentally undifferentiated states adulthood, though they are generated before birth. Here, the occurrence, distribution cellular features cINs were systematically studied 12 diverse species spanning from small-lissencephalic to...