A5026112989- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Attention Deficit Hyperactivity Disorder
- Child Abuse and Trauma
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Mental Health and Psychiatry
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Amino Acid Enzymes and Metabolism
- Neurological disorders and treatments
- Mental Health Treatment and Access
- Diet and metabolism studies
- Liver Disease and Transplantation
- Child and Adolescent Health
- Genetic Associations and Epidemiology
- Mental Health Research Topics
- Health Systems, Economic Evaluations, Quality of Life
- Hepatitis C virus research
Instituto de Salud Carlos III
2014-2025
Centro de Investigación Biomédica en Red de Salud Mental
2015-2025
Hospital General Universitario Gregorio Marañón
2015-2025
The University of Melbourne
2015-2025
Melbourne Health
2014-2024
Universidad Complutense de Madrid
2014-2024
Centre for Biomedical Network Research on Rare Diseases
2022-2024
University of Bologna
2023
Hospital Clínico San Carlos
2023
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2023
Cannabis use is associated with increased risk of later psychotic disorder but whether it affects incidence the remains unclear. We aimed to identify patterns cannabis strongest effect on odds across Europe and explore differences in such contribute variations rates disorder.
OBJECTIVE The authors sought to assess the efficacy of functional remediation, a novel intervention program, on improvement in sample euthymic patients with bipolar disorder. METHOD In multicenter, randomized, rater-blind clinical trial involving 239 outpatients DSM-IV disorder, remediation (N=77) was compared psychoeducation (N=82) and treatment as usual (N=80) over 21 weeks. Pharmacological kept stable all three groups. primary outcome measure global psychosocial functioning, measured...
Background/Objectives: Decompensated cirrhosis is characterized by systemic inflammation and innate adaptive immune dysfunction. Hepatic encephalopathy (HE) a prevalent debilitating condition cognitive disturbances in which ammonia play synergistic pathogenic role. Extraskeletal functions of vitamin D include immunomodulation, its deficiency has been implicated dysfunction different forms impairment. The aim was to assess changes function decompensated patients with receiving...
Background/Objective: The heterogeneous clinical presentations of individuals with Autism Spectrum Disorders (ASD) pose a significant challenge for sample characterization. Therefore the main goal DSM-5 must be to identify subgroups ASD, including comorbidity disorders and severity. this study is explore psychiatric comorbidities severity symptoms that could relevant phenotype characterization in ASD also compare these results according different classification criteria between DSM-IV-TR...
Background Cognitive deficits are predictors of functional outcome in patients with psychosis. While conventional antipsychotics relatively effective on positive symptoms, their impact negative and cognitive symptoms is limited. Recent studies have established a link between oxidative stress neurocognitive N -acetylcysteine (NAC), glutathione precursor glutamatergic properties, has shown efficacy functioning schizophrenia bipolar disorder, respectively. However, there few evidence-based...
Increasing evidence supports the important role of illness state and individual characteristics in insight.Insight, as measured with Scale to Assess Unawareness Mental Disorder, over first 2 years early-onset first-episode psychosis its correlations clinical, socio-demographic, cognitive, structural brain variables are studied.(1) insight at is poorer schizophrenia spectrum disorders (SSDs) than subjects other psychoses; (2) more severe psychosis, worse insight. In SSD, depressive symptoms,...
Background The longitudinal neuropsychological study of first-episode early-onset psychosis (EOP) patients, whose brain maturation is still in progress at the time illness onset, provides a unique opportunity to compare their cognitive development with that healthy subjects, search specific patterns resulting from interaction between neurodevelopmental processes and presence psychotic disorders. Method Seventy-five EOP patients (schizophrenia n = 35; bipolar disorder 17; other forms 23) mean...
Tobacco use in mental health general and bipolar disorder particular remains disproportionally common, despite declining smoking rates the community. Furthermore, interactions between tobacco have been shown, indicating outcomes for those with disorders are impacted by use. Factors need to be explored addressed improve these target specific interventions people psychiatric illness cease smoking. In context of disorder, this review explores; effects on symptoms, quality life, suicidal...
This study investigates the impact of childhood maltreatment (CM) on hypothalamic-pituitary-adrenal (HPA)-axis functioning and anxiety perception. Moreover, influence CM severity frequency was also explored.In total, 187 participants aged 7-17 were assessed for history using validated questionnaires ad hoc interviews to be classified according criteria Tool Assessing Severity Situations in which Children are Vulnerable (TASSCV). Psychopathology ascertained K-SADS-PL5. To assess HPA-axis...
Background/aim: Frailty is increasingly recognized as a relevant prognostic factor in patients with cirrhosis, regardless of liver failure. Vitamin D deficiency frequent these and has been related to frailty sarcopenia, but the impact its supplementation on cirrhosis unknown. The aim was evaluate effect vitamin decompensated or insufficiency. Methods: We included who had insufficiency following their hospitalization for acute decompensation. supplemented according current recommendations,...
The objective of the study is to examine association baseline total antioxidant status (TAS) and glutathione (GSH) levels with short- long-term cognitive functioning in patients early onset first-episode psychosis, comparing affective non-affective psychoses. We analysed 105 an onset-first episode psychosis (age 9-17 years) 97 healthy controls. Blood samples were taken at admission for measurement TAS GSH, performance was assessed 2years follow-up. Regression analysis used assess...
Background: In recent decades, the assessment of neurological soft signs (NSS) in patients with psychosis has become a subject special interest. The study progression NSS during adolescence will provide valuable information about role as endophenotypes or biomarkers and brain development at stage which maturation not yet been completed. Methods: Neurological were assessed sample 110 first episodes early‐onset (EOP) 98 healthy children adolescents two different times 2‐year follow‐up period....
Abstract Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from EU-GEI study, we evaluated impact schizophrenia polygenic risk score (SZ-PRS) and patterns cannabis use on transdiagnostic We analysed first-episode psychosis patients (FEP) controls, generating dimensions psychotic symptoms experiences using item response bi-factor modelling. Linear regression was used to test associations between these SZ-PRS, as well combined effect SZ-PRS...
To investigate the relationship between cognition and prior cannabis use in children adolescents presenting a first episode of psychosis. A total 107 patients with psychosis 96 healthy controls, aged 9 to 17 years, were interviewed about their previous substance assess cognitive functions. Patients assessed while not using by means comprehensive neuropsychological battery. They divided into 2 groups depending on history use: users (CU) nonusers (CNU). Significant differences found all areas...