A5009397419- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Neurobiology of Language and Bilingualism
- Bipolar Disorder and Treatment
- Amyotrophic Lateral Sclerosis Research
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Mental Health Research Topics
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Posttraumatic Stress Disorder Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Vestibular and auditory disorders
- Child and Adolescent Psychosocial and Emotional Development
- Spatial Neglect and Hemispheric Dysfunction
- Migration, Health and Trauma
- Fetal and Pediatric Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- Action Observation and Synchronization
- Neurological and metabolic disorders
The University of Sydney
2017-2025
ARC Centre of Excellence in Cognition and its Disorders
2016-2024
Centro de Investigación Biomédica en Red de Salud Mental
2011-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2022
Universitat de Barcelona
2013-2022
Cooperative Trials Group for Neuro-Oncology
2022
Australian Research Council
2017-2021
UNSW Sydney
2016-2021
Fidmag Sisters Hospitallers
2011-2021
Neuroscience Research Australia
2016-2018
OBJECTIVE The authors sought to assess the efficacy of functional remediation, a novel intervention program, on improvement in sample euthymic patients with bipolar disorder. METHOD In multicenter, randomized, rater-blind clinical trial involving 239 outpatients DSM-IV disorder, remediation (N=77) was compared psychoeducation (N=82) and treatment as usual (N=80) over 21 weeks. Pharmacological kept stable all three groups. primary outcome measure global psychosocial functioning, measured...
The typical presentation of semantic dementia is associated with marked, left predominant anterior temporal lobe atrophy and changes in language. About 30% individuals, however, present right atrophy, usually accompanied by behavioural prosopagnosia. Here, we aimed to establish whether these initially distinct clinical presentations evolve into a similar syndrome at the neural level. Thirty-one patients who presented were included. Based on imaging, categorized as either ( n = 22) or 9)...
The effect of cultural differences in neurodegenerative diseases is not well understood. We aimed to investigate the cognitive profiles English- and Spanish-speaking individuals with primary progressive aphasia (PPA). A comparative cross-sectional study was conducted 461 participants: 215 participants from Australia 246 Spain. Australian cohort included 131 PPA patients: 37 nonfluent (nfvPPA), 49 semantic (svPPA), 45 logopenic (lvPPA) 84 healthy controls (HC); Spanish had 162 PPA: 64 nfvPPA,...
Abstract Background Social cognition has been associated with functional outcome in patients first episode psychosis (FEP). also neurocognition and cognitive reserve. Although reserve, neurocognitive functioning, social cognition, are related, the direction of their associations is not clear. Therefore, main aim this study was to analyze influence as a mediator between reserve domains on functioning FEP both at baseline 2 years. Methods The sample composed 282 followed up for To whether...
Abstract As a global health emergency, the rapid spread of novel coronavirus disease (COVID-19) led to implementation widespread restrictions (e.g., quarantine, physical/social distancing measures). However, while these reduce viral COVID-19, they may exacerbate behavioural and cognitive symptoms in dementia patients increase pressure on caregiving. Here, we aimed assess impact COVID-19 related both carers people living with across world. We conducted an international survey (Australia,...
Heterozygous mutations in the GRN gene and hexanucleotide repeat expansions C9orf72 are two most common genetic causes of Frontotemporal Dementia (FTD) with TDP-43 protein inclusions. The triggers for neurodegeneration FTD (FTD-GRN) or (FTD-C9orf72) abnormalities unknown, although evidence from mouse cell culture models suggests that disrupt lysosomal lipid catabolism. To determine how brain metabolism is affected familial inclusions, this related to myelin markers, we undertook...
This present study aims to address the gap in literature regarding severity and underlying neural correlates of psychotic symptoms frontotemporal dementia with without
Objective Brain structural changes in schizoaffective disorder, and how far they resemble those seen schizophrenia bipolar have only been studied to a limited extent. Method Forty‐five patients meeting DSM ‐ IV RDC criteria for groups of with 45 matched healthy controls were examined using voxel‐based morphometry ( VBM ). Results Analyses comparing each patient group the control subjects found that disorder showed widespread overlapping areas significant volume reduction, but did not. A...
Objective Increasing evidence suggests that cerebellar damage impacts on cognitive functions. Frontotemporal dementias (FTDs) are neurodegenerative brain conditions, primarily affecting the frontal and/or temporal lobe. Three main phenotypes recognized, each with a distinct clinical and profile: behavioral‐variant FTD (bvFTD), semantic dementia (SD), progressive nonfluent aphasia (PNFA). The severity of changes their relation to cognition in FTD, however, remain unclear. This study aimed...
SEE FINGER DOI101093/AWW312 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Abnormal eating behaviour and metabolic parameters including insulin resistance, dyslipidaemia body mass index are increasingly recognized as important components of neurodegenerative disease may contribute to survival. It has previously been established that behavioural variant frontotemporal dementia is associated with abnormal characterized by increased sweet preference. In this study, it was hypothesized might also...
Abstract Biomarkers represent a critical research area in neurodegeneration disease as they can contribute to studying potential disease‐modifying agents, fostering timely therapeutic interventions, and alleviating associated financial costs. Functional connectivity (FC) analysis represents promising approach identify early biomarkers specific diseases. Yet, virtually no study has tested whether FC prove be reliable reproducible across different centers. As such, their implementation remains...
To identify distinct behavioral phenotypes of behavioral-variant frontotemporal dementia (bvFTD) and to elucidate differences in functional, neuroimaging, progression residential care placement.Eighty-eight patients with bvFTD were included a cluster analysis applying levels disinhibition apathy (Cambridge Behavioural Inventory-Revised) phenotypic subgroups. Between-group (Kruskal-Wallis, Mann-Whitney U) functional (Disability Assessment for Dementia) time placement (survival analyses)...
Background. Functional imaging studies in relatives of schizophrenic patients have had inconsistent findings, particularly with respect to altered dorsolateral prefrontal cortex activation. Some recent also suggested that failure deactivation may be seen. Method. A total 28 schizophrenia, their siblings and 56 healthy controls underwent functional magnetic resonance during performance the n-back working memory task. An analysis variance was fitted individual whole-brain maps from each set...
Eye Movement Desensitization and Reprocessing (EMDR) is considered highly efficacious for the treatment of Post-traumatic Stress Disorder has proved to be a valid approach with wide range applications. However, EMDR's mechanisms action not yet fully understood. This an active area clinical neurophysiological research, several different hypotheses have been proposed. paper discusses conjecture which focuses on similarity between delta waves recorded by electroencephalography during Slow Wave...
Up to 60% of patients with bipolar disorder (BD) have a history traumatic events, which is associated greater episode severity, higher risk comorbidity and relapse rates. Trauma-focused treatment strategies for BD are thus necessary but studies currently scarce. The aim this study examine whether Eye Movement Desensitization Reprocessing (EMDR) therapy focusing on adherence, insight, de-idealisation manic symptoms, prodromal symptoms mood stabilization can reduce severity rates increase...
Patients with schizophrenia are known to have increased prevalence of abnormalities in midline brain structures, such as a failure the septum pellucidum fuse (cavum pellucidum) and absence adhesio interthalamica. This is first study investigate these across large multidiagnostic sample. Presence cavum interthalamica was assessed 639 patients chronic schizophrenia, delusional disorder, schizoaffective bipolar major depressive or episode psychosis, mania unipolar depression. compared 223...
Abstract Introduction Timely diagnosis of behavioral variant frontotemporal dementia (bvFTD) remains challenging because it depends on clinical expertise and potentially ambiguous diagnostic guidelines. Recent recommendations highlight the role multimodal neuroimaging machine learning methods as complementary tools to address this problem. Methods We developed an automatic, cross‐center, computational approach for robust classification patients with bvFTD healthy controls. analyzed...