Hannah E. Jongsma
A5079239452- Schizophrenia research and treatment
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Health disparities and outcomes
- Cannabis and Cannabinoid Research
- Child and Adolescent Psychosocial and Emotional Development
- Migration, Health and Trauma
- Mental Health and Psychiatry
- Racial and Ethnic Identity Research
- Mental Health Research Topics
- Homelessness and Social Issues
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Child Abuse and Trauma
- Obsessive-Compulsive Spectrum Disorders
- Employment and Welfare Studies
- Cultural Competency in Health Care
- Functional Brain Connectivity Studies
- Digital Mental Health Interventions
- Counseling Practices and Supervision
- Psychiatric care and mental health services
- Adolescent and Pediatric Healthcare
- Family Caregiving in Mental Illness
- Global Health Care Issues
University Medical Center Groningen
2021-2025
University of Groningen
2021-2024
University of Cambridge
2017-2024
GGZ Rivierduinen
2024
Cambridgeshire and Peterborough NHS Foundation Trust
2024
University College London
2019-2023
University of Bologna
2023
Bangor University
2020
Betsi Cadwaladr University Health Board
2020
King's College London
2015
Cannabis use is associated with increased risk of later psychotic disorder but whether it affects incidence the remains unclear. We aimed to identify patterns cannabis strongest effect on odds across Europe and explore differences in such contribute variations rates disorder.
Psychotic disorders contribute significantly to the global disease burden, yet latest international incidence study of psychotic was conducted in 1980s.To estimate using comparable methods across 17 catchment areas 6 countries and examine variance between by putative environmental risk factors.An multisite (the European Network National Schizophrenia Networks Studying Gene-Environment Interactions) from May 1, 2010, April 2015, among 2774 individuals England (2 areas), France (3 Italy...
<h3>Background</h3> Concerns about adverse effects on patient satisfaction may be an important obstacle to attempts curtail antibiotic prescribing. <h3>Aim</h3> To determine the relationship between prescribing in general practice and reported satisfaction. <h3>Design setting</h3> Retrospective cross-sectional study of practices England. <h3>Method</h3> Data were obtained from General Practice Patient Survey (GPPS) 2012 (2.7 million questionnaires England; 982 999 responses; response rate...
Abstract Background The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate transdiagnostic dimensional structure associated characteristics psychopathology at First Episode Psychosis (FEP). Regardless diagnostic categories, we expected that positive symptoms occurred more in ethnic minority groups densely populated environments, negative were with indices neurodevelopmental impairment. Method This study...
Ethnic minority groups in Western countries face an increased risk of psychotic disorders. Causes this long-standing public health inequality remain poorly understood. We investigated whether social disadvantage, linguistic distance and discrimination contributed to these patterns.We used case-control data from the EUropean network national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study, carried out 16 centres six countries. recruited 1130 cases 1497...
Daily use of high-potency cannabis has been reported to carry a high risk for developing psychotic disorder. However, the evidence is mixed on whether any pattern associated with particular symptomatology in first-episode psychosis (FEP) patients.We analysed data from 901 FEP patients and 1235 controls recruited across six countries, as part European Network National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. We used item response modelling estimate two...
The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity minority ethnic groups; (2) the role multiple environmental genetic risk factors, their interactions, development psychotic disorders.Between 2010 2015, we identified 2774 incident cases disorders during 12.9...
The 'jumping to conclusions' (JTC) bias is associated with both psychosis and general cognition but their relationship unclear. In this study, we set out clarify the between JTC bias, IQ, polygenic liability schizophrenia IQ.A total of 817 first episode patients 1294 population-based controls completed assessments intelligence (IQ), JTC, provided blood or saliva samples from which extracted DNA computed risk scores for IQ schizophrenia.The estimated proportion effect case/control differences...
Abstract Background Psychosis rates are higher among some migrant groups. We hypothesized that psychosis in migrants is associated with cumulative social disadvantage during different phases of migration. Methods used data from the EUropean Network National Schizophrenia Networks studying Gene-Environment Interactions (EU-GEI) case–control study. defined a set three indicators for each phase: pre-migration, migration and post-migration. examined whether pre- post-migration phases,...
Abstract Background Schizophrenia (SZ), bipolar disorder (BD) and depression (D) run in families. This susceptibility is partly due to hundreds or thousands of common genetic variants, each conferring a fractional risk. The cumulative effects the associated variants can be summarised as polygenic risk score (PRS). Using data from EUropean Network national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) first episode case–control study, we aimed test whether PRSs for...
Facial Emotion Recognition is a key domain of social cognition associated with psychotic disorders as candidate intermediate phenotype. In this study, we set out to investigate global and specific facial emotion recognition deficits in first-episode psychosis, whether polygenic liability recognition.828 First Episode Psychosis (FEP) patients 1308 population-based controls completed assessments the Degraded Affect Task (DFAR) subsample 524 FEP 899 provided blood or saliva samples from which...
Abstract Background Previous studies identified clusters of first-episode psychosis (FEP) patients based on cognition and premorbid adjustment. This study examined a range socio-environmental risk factors associated with FEP, aiming a) to compare FEP community controls using the Maudsley Environmental Risk Score for (ERS), weighted sum following risks: paternal age, childhood adversities, cannabis use, ethnic minority membership; b) explore putative differences in specific environmental...
Abstract Background In Europe, the incidence of psychotic disorder is high in certain migrant and minority ethnic groups (hence: ‘minorities’). However, it unknown how pattern for these varies within this continent. Our objective was to compare, across sites France, Italy, Spain, UK Netherlands, rates minorities rate ratios (IRRs, v. local reference population). Methods The European Network National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study conducted...
The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset disorder, potentially ignoring important confounding relationships or fact that some may be consequence disorder rather than preexisting. study subclinical could help to address these issues. In this study, we investigated whether there was (i) an association between dimensions several including: childhood trauma, self-reported discrimination experiences, low social capital,...
Abstract Background Incidence of first-episode psychosis (FEP) varies substantially across geographic regions. Phenotypes subclinical (SP), such as psychotic-like experiences (PLEs) and schizotypy, present several similarities with psychosis. We aimed to examine whether SP measures varied different sites this variation was comparable FEP incidence within the same areas. further examined contribution environmental genetic factors SP. Methods used data from 1497 controls recruited in 16 6...
Background The Cultural Formulation Interview (CFI) is designed to improve understanding of patients’ mental health care needs. lack empirical evidence on the impact and effectiveness CFI use in clarifying people’s perspectives, experiences, context, identity, preventing cultural misunderstandings between migrant patients clinicians, inspired this study. objective examine effect strength therapeutic working alliances, potential mediating or moderating role perceived empathy. Materials...
Abstract Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from EU-GEI study, we evaluated impact schizophrenia polygenic risk score (SZ-PRS) and patterns cannabis use on transdiagnostic We analysed first-episode psychosis patients (FEP) controls, generating dimensions psychotic symptoms experiences using item response bi-factor modelling. Linear regression was used to test associations between these SZ-PRS, as well combined effect SZ-PRS...
Abstract Background A history of childhood adversity is associated with psychotic disorder, an increase in risk according to the number exposures. However, it not known why only some exposed individuals go on develop psychosis. One possibility pre-existing polygenic vulnerability. Here, we investigated, largest sample first-episode psychosis (FEP) cases date, whether and high scores for schizophrenia (SZ-PRS) combine synergistically psychosis, over above effect each alone. Methods We...