Charlotte Gayer‐Anderson
A5068470582- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Cannabis and Cannabinoid Research
- Mental Health Treatment and Access
- Mental Health Research Topics
- Mental Health and Psychiatry
- Health disparities and outcomes
- Tryptophan and brain disorders
- Child Abuse and Trauma
- Psychosomatic Disorders and Their Treatments
- Migration, Health and Trauma
- Stress Responses and Cortisol
- Suicide and Self-Harm Studies
- Epigenetics and DNA Methylation
- Homelessness and Social Issues
- Psychedelics and Drug Studies
- Adolescent and Pediatric Healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Racial and Ethnic Identity Research
- Resilience and Mental Health
- Bullying, Victimization, and Aggression
- Education Discipline and Inequality
- Functional Brain Connectivity Studies
King's College London
2016-2025
University of Bologna
2023
Economic and Social Research Council
2020
National Institute for Health Research
2016
South London and Maudsley NHS Foundation Trust
2016
University of London
2014
Cannabis use is associated with increased risk of later psychotic disorder but whether it affects incidence the remains unclear. We aimed to identify patterns cannabis strongest effect on odds across Europe and explore differences in such contribute variations rates disorder.
Psychotic disorders contribute significantly to the global disease burden, yet latest international incidence study of psychotic was conducted in 1980s.To estimate using comparable methods across 17 catchment areas 6 countries and examine variance between by putative environmental risk factors.An multisite (the European Network National Schizophrenia Networks Studying Gene-Environment Interactions) from May 1, 2010, April 2015, among 2774 individuals England (2 areas), France (3 Italy...
While contemporary models of psychosis have proposed a number putative psychological mechanisms, how these impact on individuals to increase intensity psychotic experiences in real life, outside the research laboratory, remains unclear. We aimed investigate whether elevated stress sensitivity, aberrant novelty and salience, enhanced anticipation threat contribute development daily life. used experience sampling method (ESM) assess stress, negative affect, anticipation, 51 with first-episode...
There is a substantial body of research reporting evidence associations between various forms childhood adversity and psychosis, across the spectrum from experiences to disorder. This has been extended, more recently, include studies cumulative effects, interactions with other factors, specific putative biological psychological mechanisms. In this paper we evaluate highlight remaining methodological issues gaps that temper, but do not dismiss, conclusions about causal role adversity. We also...
BackgroundAlthough cannabis use after a first episode of psychosis has been associated with relapse, little is known about the determinants this most preventable risk factor for relapse psychosis. Here we aimed to study whether effects on outcome vary depending type consumed and usage pattern.MethodsIn observational study, prospectively recruited followed up patients aged 18–65 years who presented their psychiatric services in south London, UK. Relapse within 2 onset was defined as...
Background Evidence has accumulated that implicates childhood trauma in the aetiology of psychosis, but our understanding putative psychological processes and mechanisms through which impacts on individuals contributes to development psychosis remains limited. We aimed investigate whether stress sensitivity threat anticipation underlie association between abuse psychosis. Method used Experience Sampling measure stress, anticipation, negative affect, psychotic experiences 50 first-episode...
Abstract Background Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive (MDD), educational attainment (EA), and IQ, but very few studies examined associations these PRS cognitive phenotypes within schizophrenia cases. Methods We combined data in 3034 cases from 11 samples using the general intelligence factor g as primary measure cognition....
Abstract Background The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate transdiagnostic dimensional structure associated characteristics psychopathology at First Episode Psychosis (FEP). Regardless diagnostic categories, we expected that positive symptoms occurred more in ethnic minority groups densely populated environments, negative were with indices neurodevelopmental impairment. Method This study...
Ethnic minority groups in Western countries face an increased risk of psychotic disorders. Causes this long-standing public health inequality remain poorly understood. We investigated whether social disadvantage, linguistic distance and discrimination contributed to these patterns.We used case-control data from the EUropean network national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study, carried out 16 centres six countries. recruited 1130 cases 1497...
Several integrated models of psychosis have implicated adverse, stressful contexts and experiences, affective cognitive processes in the onset psychosis. In these models, effects stress are posited to contribute development psychotic experiences via pathways through disturbance, biases, anomalous experiences. However, attempts systematically test comprehensive remain sparse. Using Experience Sampling Method 51 individuals with first-episode (FEP), 46 an at-risk mental state (ARMS) for...
Daily use of high-potency cannabis has been reported to carry a high risk for developing psychotic disorder. However, the evidence is mixed on whether any pattern associated with particular symptomatology in first-episode psychosis (FEP) patients.We analysed data from 901 FEP patients and 1235 controls recruited across six countries, as part European Network National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study. We used item response modelling estimate two...
The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity minority ethnic groups; (2) the role multiple environmental genetic risk factors, their interactions, development psychotic disorders.Between 2010 2015, we identified 2774 incident cases disorders during 12.9...
Background Mental health problems are not distributed equally in society. Our understanding of when social inequalities mental emerge is limited. We sought to examine trajectories distress diverse, representative cohorts adolescents inner-London. Methods analysed longitudinal data from our cohort study adolescent health, REACH (n=4663; 51% girls, 29% free school meals [FSM], 85% minoritised ethnic groups). used latent growth curve models estimate (total, internalising, and externalising...
Research suggests gender inequalities in adolescent mental health are context dependent and might be preventable through social structural change. However, variations the size of across diverse cultural contexts could due to incomparable measurement. We aimed compare a measurement among young people Tokyo, Japan, London, UK, test hypothesis that depressive symptom trajectories larger London than Tokyo. For this longitudinal cross-cohort study, we extracted responses 13-item Short Mood...
Little is known about patients with a first episode of psychosis (FEP) who had presented to prodromal services an "at risk mental state" (ARMS) before making the transition psychosis. We set out identify proportion FEP in ARMS state, and compare these did not have prior contact services. In this study information on 338 aged ≤37 years health between 2010 2012 was examined. The data pathways care, clinical socio-demographic characteristics were extracted from Biomedical Research Council Case...
A growing body of evidence suggests that indicators social disadvantage are associated with an increased risk psychosis. However, only a few studies have specifically looked at cumulative effects and long-term associations. The aims this study are: To compare the prevalence specific at, prior to, first contact psychiatric services in patients suffering their episode psychosis control sample. explore associations, effects, direction effects.
The 'jumping to conclusions' (JTC) bias is associated with both psychosis and general cognition but their relationship unclear. In this study, we set out clarify the between JTC bias, IQ, polygenic liability schizophrenia IQ.A total of 817 first episode patients 1294 population-based controls completed assessments intelligence (IQ), JTC, provided blood or saliva samples from which extracted DNA computed risk scores for IQ schizophrenia.The estimated proportion effect case/control differences...
Background Adolescence is a critical period for social and emotional development. We sought to examine the impacts of Covid‐19 related restrictions school closures on adolescent mental health, particularly among disadvantaged, marginalised, vulnerable groups. Methods analysed four waves data – 3 pre‐Covid‐19 (2016–2019) 1 mid‐Covid‐19 (May–Aug 2020; n , 1074; 12–18 years old, >80% minority ethnic groups, 25% free meals) from REACH (Resilience, Ethnicity, AdolesCent Mental Health), an...
Childhood adversity (variously defined) is a robust risk factor for psychosis, yet the mitigating effects of social support in adulthood have not been explored. This study aimed to investigate relationships between childhood sexual and physical abuse adult gender differences levels perceived support. A sample 202 individuals presenting first time mental health services with psychosis 266 population-based controls from south-east London Nottingham, UK, was utilised. The Experience Care Abuse...