A5020174111- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Complement system in diseases
- Tryptophan and brain disorders
- Congenital heart defects research
- Genomic variations and chromosomal abnormalities
- Autism Spectrum Disorder Research
- Cognitive Abilities and Testing
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Single-cell and spatial transcriptomics
- Health, Environment, Cognitive Aging
- Attention Deficit Hyperactivity Disorder
- Adolescent and Pediatric Healthcare
- Neuroscience and Neuropharmacology Research
- Reproductive System and Pregnancy
- Ion channel regulation and function
- Diabetes and associated disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Skin and Cellular Biology Research
- Advanced Neuroimaging Techniques and Applications
Ollscoil na Gaillimhe – University of Galway
2015-2020
National University of Ireland
2019
University of Southern California
2017
Abstract Background Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive (MDD), educational attainment (EA), and IQ, but very few studies examined associations these PRS cognitive phenotypes within schizophrenia cases. Methods We combined data in 3034 cases from 11 samples using the general intelligence factor g as primary measure cognition....
Epigenetic mechanisms are an important heritable and dynamic means of regulating various genomic functions, including gene expression, to orchestrate brain development, adult neurogenesis, synaptic plasticity. These processes when perturbed thought contribute schizophrenia pathophysiology. A core feature is cognitive dysfunction. For genetic disorders where impairment more severe such as intellectual disability, there a disproportionally high number genes involved in the epigenetic...
Abstract Variants at microRNA-137 (MIR137) , one of the most strongly associated schizophrenia risk loci identified to date, have been with poorer cognitive performance. As is known regulate expression ~1900 other genes, including several that are independently schizophrenia, we tested whether this gene set was also variation in Our analysis based on an empirically derived list genes whose altered by manipulation MIR137 expression. This cross-referenced genome-wide association data construct...
Abstract Background The longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially, by structural variation at complement component 4 ( C4 ) gene. This generates varying levels of RNA expression, genetic information from MHC region can now be used to predict expression in brain. Increased predicted C4A is associated with SZ, reported influence synaptic pruning animal models. Methods Based on our...
Abstract Myocyte enhancer factor 2 C (MEF2C) is an important transcription during neurodevelopment. Mutation or deletion of MEF2C causes intellectual disability (ID), and common variants within are associated with cognitive function schizophrenia risk. We investigated if genes influenced by neurodevelopment enriched for neurodevelopmental phenotypes this can be leveraged to identify biological mechanisms individual brain cell types affected. used a set 1055 that were differentially expressed...
Variation in cognitive performance, which strongly predicts functional outcome schizophrenia (SZ), has been associated with multiple immune-relevant genetic loci. These loci include complement component 4 (C4A), structural variation at was recently SZ risk and synaptic pruning during neurodevelopment function. Here, we test whether this association cognition is specific to C4A, or extends more broadly genes related the system. Using a gene-set an identified role "complement" function...
Multiple genome-wide association studies of schizophrenia have reported associations between genetic variants within the MHC region and disease risk, an that has been partially accounted for by alleles complement component 4 (C4) gene. Following on previous findings both C4 other complement-related memory function, we tested hypothesis polygenic scores calculated based identified risk "complement" system would be broadly associated with function brain structure. We this using a score (PRS)...
Multiple genome‐wide association studies of schizophrenia have implicated genetic variants within the gene encoding microRNA‐137. As risk or regulated by MIR137 been in memory performance, we investigated additive effects schizophrenia‐associated genes empirically on brain regions associated with function. A polygenic score (PRS) was calculated (at a p = 0.05 threshold), using this set, to investigate associations between PRS and structural measures. These measures included total volume,...
Abstract Myocyte enhancer factor 2 C (MEF2C) is an important transcription during neurodevelopment. Mutation or deletion of MEF2C causes intellectual disability (ID) and common variants within are associated with cognitive function schizophrenia risk. We investigated if genes influenced by neurodevelopment enriched for neurodevelopmental phenotypes, this can be leveraged to identify biological mechanisms individual brain cell types affected. used a set 1,052 that were differentially...
Event Abstract Back to Polygenic scores from the MiR137 pathway explain variability in cognitive performance patients with schizophrenia and controls. Donna Cosgrove1*, Derek Morris1, Ric Anney2, April Hargreaves2, Psychiatric Genomics Consortium1, Michael Gill2, Aiden Corvin2 Gary Donohoe1 1 The Cognitive Genetics & Therapy Group, Depts. of Psychology Biochemistry, National University Ireland Galway, 2 Neuropsychiatric Research Department Psychiatry, Institute Molecular Medicine, Trinity...