A5041062908- Mental Health Research Topics
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Digital Mental Health Interventions
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Behavioral Health and Interventions
- Congenital heart defects research
- Child and Adolescent Psychosocial and Emotional Development
- Neurotransmitter Receptor Influence on Behavior
- Neural and Behavioral Psychology Studies
- Action Observation and Synchronization
- COVID-19 and Mental Health
- Child and Animal Learning Development
- Attention Deficit Hyperactivity Disorder
- Stress Responses and Cortisol
- Psychosomatic Disorders and Their Treatments
- Neonatal and fetal brain pathology
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Long-Term Effects of COVID-19
- Resilience and Mental Health
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
KU Leuven
2015-2023
Maastricht University
2014-2021
Contextual Change (United States)
2019
Maastricht University Medical Centre
2016
European Graduate School of Neuroscience
2014-2015
University of Maryland, Baltimore
2010-2013
In the mental health field, there is a growing awareness that study of psychiatric symptoms in context everyday life, using experience sampling methodology (ESM), may provide powerful and necessary addition to more conventional research approaches. ESM, structured self-report diary technique, allows investigation experiences within, interaction with, real-world context. This paper provides an overview how zooming on micro-level behaviour ESM adds new insights additional perspectives standard...
Abstract The SARS-CoV-2 pandemic is not only a threat to physical health but also having severe impacts on mental health. Although increases in stress-related symptomatology and other adverse psycho-social outcomes, as well their most important risk factors have been described, hardly anything known about potential protective factors. Resilience refers the maintenance of despite adversity. To gain mechanistic insights relationship between described resilience specifically current crisis, we...
Patients with schizophrenia (SZ) show deficits on tasks of rapid reinforcement learning, like probabilistic reversal learning (PRL), but the neural bases for those impairments are not known. Recent evidence relatively intact sensitivity to negative outcomes in ventral striatum (VS) many SZ patients suggests that PRL may be largely attributable processes downstream from feedback processing, involving both activation executive control task regions and deactivation default mode network (DMN)...
Abstract Background Psychotic experiences, social functioning and general psychopathology are important targets for early intervention in individuals with Ultra-High-Risk state (UHR) a first-episode psychosis (FEP). Acceptance Commitment Therapy (ACT) is promising, next-generation Cognitive Behavioural (CBT) that aims to modify these targets, but evidence on sustainable change its underlying mechanisms individuals’ daily lives remains limited. The aim of the INTERACT study investigate...
The SARS-CoV-2 pandemic is not only a threat to physical health but also having severe impacts on mental health. While increases in stress-related symptomatology and other adverse psycho-social outcomes as well their most important risk factors have been described, hardly anything known about potential protective factors. Resilience refers the maintenance of despite adversity. In order gain mechanistic insights relationship between described resilience specifically current crisis, we...
Background: Over half of all mental health conditions have their onset in adolescence. Large-scale epidemiological studies identified relevant environmental risk factors for problems. Yet, few focused on potential mediating inter- and intrapersonal processes daily life, hampering intervention development. Objectives: To investigate 1) the impact changes processes; 2) altered development (sub)clinical symptoms adolescents and; 3) extent to which mediate association between outcomes...
Background: With the development of mHealth, it is possible to treat patients in their natural environment. Mobile technology helps bridge gap between therapist's office and "real world." The ACT Daily Life training (ACT-DL) was designed as an add-on intervention help practice with acceptance commitment therapy daily lives. ACT-DL consists two main components: monitoring using experience sampling life. Objectives: To assess acceptability feasibility a general outpatient population. A...
Sleep disturbances are prevalent among individuals with a psychotic disorder and have been linked to symptoms of paranoia across the entire psychosis continuum. Emerging evidence suggests that rather than secondary symptom, poor quality sleep may contribute elevated paranoid ideation. We investigated temporal dynamics ideation using experience sampling method in 42 acutely disorder, 32 nonparanoid 41 high schizotypy traits. applied time-lagged mixed multilevel modeling tease apart effect on...
Previous studies have typically found that individuals with schizophrenia (SZ) report levels of emotional experience are similar to controls (CN) when asked view a single evocative stimulus and make an absolute judgment "value." However, value is rarely assigned in terms real-life situations, where one alternative or often evaluated alongside others, judgments made relative terms. In the current study, we examined performance on preference task requires differentiate between values different...
The experience sampling method (ESM) is a structured diary with high ecological validity, in that it accurately captures the everyday context of individuals through repeated measurements naturalistic environments. Our main objective was to investigate feasibility using ESM acquired brain injury (ABI). A second goal explore usability data on clinical level, by illustrating interactions between person, environment, and affect. PsyMate device provided ABI patients (N = 17) ten signals (beeps)...
Abstract Background It remains poorly understood how negative symptoms are experienced in the daily lives of individuals early stages psychosis. We aimed to investigate whether altered affective experience, anhedonia, social and asociality were more pronounced with an at-risk mental state for psychosis (ARMS) first-episode (FEP) than controls. Methods used experience sampling methodology (ESM) assess symptoms, as they occurred life 51 FEP 46 ARMS, compared 53 Results Multilevel linear...
Background: Experiences of sudden and abrupt insight, sometimes termed aha-experiences, are often reported during psychosis. The aha-experience is described as a radical restructuring, realization or change in understanding. Based on personal experience, we argued that alongside this aha experience exists the anti-aha-experience. anti-aha-experience refers to an insight does not fit within one's framework, convictions worldview has undermining effect. We have conceptualized psychosis...
Abstract Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with an increased risk of psychiatric disorders. Vulnerability for psychopathology has been related to reactivity stress. Here, we examined affective states, perceived stress, and psychotic various sources environmental stress using the experience sampling method (ESM), structured diary technique allowing repeated assessments in context daily life. Methods Adults 22q11DS ( n = 31; age, 34.1 years)...
Many of the decisions and actions in everyday life result from implicit learning processes. Important to psychopathology are, for example, reward-seeking punishment-avoidant It is known that when specific get associated with a rewarding experience, such as positive emotions, this will increase likelihood an organism engage similar future. Similarly, punishing experiences, negative may reduce This study examines whether we can observe these processes prospectively flow daily life. If take...
Abstract Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission frontal cortex. Given DA-mediated hypofrontality hypothesized to be a cardinal feature disorder, stress-related extrastriatal DA release may altered Here we quantified for first time stress-induced and spatial extent individuals with non-affective disorder (NAPD). Twelve healthy volunteers (HV) 12 matched drug-free NAPD...