A5007947327- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Historical and Linguistic Studies
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Behavioral and Psychological Studies
- Memory and Neural Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Cognitive Abilities and Testing
- Psychology of Moral and Emotional Judgment
- Receptor Mechanisms and Signaling
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Medieval History and Crusades
- Treatment of Major Depression
University of Maryland, Baltimore
2016-2025
University of Maryland, Baltimore County
2024
Connecticut Mental Health Center
2023
Yale University
2023
University of Chicago
2023
University of Maryland, College Park
2020
University of California, Los Angeles
1998-2004
Max Planck Society
2003
University of South Florida
1986
Eastern Michigan University
1970-1976
The integration of multiple relations between mental representations is critical for higher level cognition. For both deductive- and inductive-reasoning tasks, patients with prefrontal damage exhibited a selective catastrophic deficit in the relations, whereas anterior temporal lobe damage, matched overall IQ but intact cortex, normal relational integration. In contrast, performed more accurately than on tests episodic memory semantic knowledge. These double dissociations suggest that...
Synchronized low-frequency spontaneous fluctuations of the functional MRI (fMRI) signal have recently been applied to investigate large-scale neuronal networks brain in absence specific task instructions. However, underlying neural mechanisms these remain largely unknown. To this end, electrophysiological recordings and resting-state fMRI measurements were conducted α-chloralose-anesthetized rats. Using a seed-voxel analysis strategy, region-specific, anesthetic dose-dependent connectivity...
Impairments in working memory (WM) are a core cognitive deficit schizophrenia. Neurophysiological models suggest that deficits during WM maintenance schizophrenia may be explained by abnormalities the GABAergic system, which will lead to high-frequency oscillations. However, it is not yet clear of three phases (encoding, maintenance, retrieval) affected dysfunctional oscillatory activity. We investigated relationship between impairments activity broad frequency range (3–100 Hz) and load...
Previous research has shown that patients with schizophrenia are impaired in reinforcement learning tasks. However, behavioral curves such tasks originate from the interaction of multiple neural processes, including basal ganglia- and dopamine-dependent (RL) system, but also prefrontal cortex-dependent cognitive strategies involving working memory (WM). Thus, it is unclear which specific system induces impairments schizophrenia. We recently developed a task computational model allowing us to...
Patients with schizophrenia (SZ) show reinforcement learning impairments related to both the gradual/procedural acquisition of reward contingencies, and ability use trial-to-trial feedback make rapid behavioral adjustments. We used neurocomputational modeling develop plausible mechanistic hypotheses explaining in individuals SZ. tested model a novel Go/NoGo task which subjects had learn respond or withhold responses when presented different stimuli associated probabilities gains losses...
Patients with schizophrenia (SZ) show deficits on tasks of rapid reinforcement learning, like probabilistic reversal learning (PRL), but the neural bases for those impairments are not known. Recent evidence relatively intact sensitivity to negative outcomes in ventral striatum (VS) many SZ patients suggests that PRL may be largely attributable processes downstream from feedback processing, involving both activation executive control task regions and deactivation default mode network (DMN)...
Although individuals with schizophrenia show impaired feedback-driven learning on probabilistic reversal (PRL) tasks, the specific factors that contribute to these deficits remain unknown. Recent work has suggested several potential causes including neurocognitive impairments, clinical symptoms, and types of feedback-related errors. To examine this issue, we administered a PRL task 126 stable outpatients 72 matched controls, patients were retested 4 weeks later. The involved an initial...