A5012846971- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Resilience and Mental Health
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Mental Health Research Topics
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Memory and Neural Mechanisms
Johannes Gutenberg University Mainz
2019-2023
Leibniz Institute for Resilience Research
2019-2023
University Medical Center of the Johannes Gutenberg University Mainz
2019-2023
University of Geneva
2022
Charité - Universitätsmedizin Berlin
2022
Leibniz Institute for Neurobiology
2022
Stanford Medicine
2021
Abstract The SARS-CoV-2 pandemic is not only a threat to physical health but also having severe impacts on mental health. Although increases in stress-related symptomatology and other adverse psycho-social outcomes, as well their most important risk factors have been described, hardly anything known about potential protective factors. Resilience refers the maintenance of despite adversity. To gain mechanistic insights relationship between described resilience specifically current crisis, we...
The SARS-CoV-2 pandemic is not only a threat to physical health but also having severe impacts on mental health. While increases in stress-related symptomatology and other adverse psycho-social outcomes as well their most important risk factors have been described, hardly anything known about potential protective factors. Resilience refers the maintenance of despite adversity. In order gain mechanistic insights relationship between described resilience specifically current crisis, we...
Consistent evidence from human data points to successful threat-safety discrimination and responsiveness extinction of fear memories as key characteristics resilient individuals. To promote valid cross-species approaches for the identification resilience mechanisms, we establish a translationally informed mouse model enabling stratification mice into three phenotypic subgroups following chronic social defeat stress, based on their individual ability conditioned learning:...
Chronic social defeat (CSD)-induced avoidance is considered to model a feature of stress-related mental dysfunction, while its absence has been used as proxy resilience in rodents. However, knowledge on the mechanisms shaping CSD-induced individual outcomes remains fragmentary. Fear conditioning described suitable humans for better understanding pathophysiology stress related disorders. We sought explore extent which conditioned learning involved avoidance. In experiment 1 (social...
Abstract Each year, more than half a billion people in the world are affected by stress-related health disorders. Consequently, there is an urgent need for new insights to guide interventions designed increase stress resilience. Studies of humans and various animals have uncovered process inoculation, which exposure mild stressors enhances subsequent Here, we investigate whether inoculation-induced resilience mice consistently occurs across multiplicity different contexts (tests). C57BL/6 J...
Upon chronic stress, a fraction of individuals shows stress resilience, which can prevent long-term mental dysfunction. The underlying molecular mechanisms are complex and have not yet been fully understood. In this study, we performed data-driven behavioural stratification together with single-cell transcriptomics the hippocampus in mouse model social defeat stress. Our work revealed that sub-group exhibiting responses upon dorsal is particularly involved neuroimmune responses,...
ABSTRACT Chronic social defeat (CSD) in mice has been increasingly employed experimental resilience research. Particularly, the degree of CSD-induced avoidance is used to classify animals into resilient (socially non-avoidant) versus susceptible (avoidant). In-spired by human data pointing threat-safety discrimination and responsiveness extinction training aversive memories as characteristics individuals, we here describe a translationally informed stratification which identified three...
Social stress is a major cause of the development mental disorders. To enhance translational value preclinical studies, social experience and its behavioral impact on mice should be comparable to humans. Chronic defeat (CSD) utilizes type involving physical attacks sensory threats induce dysfunctions resembling human affective strengthen psychosocial component CSD, 10-day CSD protocol was applied in which daily are standardized three 10 s episodes followed by 24 h phase. After 10th phase,...
Social stress is a major cause of the development mental disorders. To enhance translational value preclinical studies, social experience and its behavioral impact on mice should be comparable to humans. Chronic defeat (CSD) utilizes type involving physical attacks sensory threats induce dysfunctions resembling human affective strengthen psychosocial component CSD, 10-day CSD protocol was applied in which daily are standardized three 10 s episodes followed by 24 h phase. After 10th phase,...
Upon chronic stress, a fraction of individuals shows stress resilience, which can prevent long-term mental dysfunction. The underlying molecular mechanisms are complex and have not yet been fully understood. In this study, we performed data-driven behavioural stratification together with single-cell transcriptomics the hippocampus in mouse model social defeat stress. Our work revealed that sub-group exhibiting adaptive responses upon dorsal is particularly involved neuroimmune responses,...